平陈汤治疗脾虚痰湿型2型糖尿病前期患者100例
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摘要
目的:观察平陈汤对脾虚痰湿型2型糖尿病前期患者的临床疗效。方法:将100例脾虚痰湿型2型糖尿病前期患者随机分为观察组和对照组各50例。2组均给予糖尿病教育+饮食+运动的基础干预,观察组同时服用平陈汤配方颗粒,开水冲服每次200 mL,2次/d,2组均治疗8周。观察2组临床疗效及治疗前后中医证候积分、空腹血糖、胰岛素抵抗指数(IR)、体质指数(BMI)、腰围、总胆固醇(TCHO)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血压和血尿酸水平的变化情况。结果:总有效率观察组为84.75%,对照组为55.32%,2组比较差异有统计学意义(P<0.05)。中医证候总积分、空腹血糖、IR、BMI、腰围、TC、TG、HDL-C、LDL-C治疗前后组内比较,差异有统计学意义(P<0.05);治疗后组间比较差异也有统计学意义(P<0.05)。收缩压、舒张压、血尿酸治疗前后本组组内比较,差异有统计学意义(P<0.05);治疗后组间比较差异无统计学意义(P>0.05)。结论:平陈汤治疗脾虚痰湿型2型糖尿病前期患者,可以较好改善患者的临床症状及胰岛素抵抗指数等相关指标,延缓糖调节受损(IGR)向2型糖尿病的进一步发展。
Objective: To survey curative effects of PingChen decoction in the treatment for the patients with type two prediabetes of spleen deficiency phlegm damp pattern. Methods: All 100 patients were randomized into the observation group and the control group, 50 cases each group. Both groups accepted basic intervention including diabetic education+diet+exercise, and the observation group took the granules of PingChen decoction, 200 mL each time, twice each day, both groups were treated for eight weeks. The levels of blood uric acid(BUA), blood pressure,low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C), triglyceride(TG), total cholesterol(TCHO), waistline, body mass index(BMI), insulin resistance(IR), fasting blood-glucose(FBG) and TCM syndrome integrals and clinical effects of both groups were observed before and after treating. Results: Total effective rate of the observation group was 84.75%, higher than 55.32% of the control group, and the difference showed statistical meaning(P <0.05). The difference was statistically significant in the comparisons of TCM syndrome integrals, FBG, IR, BMI, waistline, TC, TG, HDL-C and LDL-C between before and after treating within the group(P<0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P <0.05). There was a significant difference in the comparisons of systolic pressure, diastolic pressure and BUA between before and after treating within the group(P <0.05); the difference had no statistical meaning in the comparisons between both groups after treating(P>0.05). Conclusion: PingChen decoction is effective in clinical intervention for the patients with type two prediabetes of spleen deficiency phlegm damp pattern, it could improve clinical symptoms and the related indexes of IR, and delay further progress of impaired glucose regulation(IGR) into type two diabetes mellitus.
Objective: To survey curative effects of PingChen decoction in the treatment for the patients with type two prediabetes of spleen deficiency phlegm damp pattern. Methods: All 100 patients were randomized into the observation group and the control group, 50 cases each group. Both groups accepted basic intervention including diabetic education+diet+exercise, and the observation group took the granules of PingChen decoction, 200 mL each time, twice each day, both groups were treated for eight weeks. The levels of blood uric acid(BUA), blood pressure,low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C), triglyceride(TG), total cholesterol(TCHO), waistline, body mass index(BMI), insulin resistance(IR), fasting blood-glucose(FBG) and TCM syndrome integrals and clinical effects of both groups were observed before and after treating. Results: Total effective rate of the observation group was 84.75%, higher than 55.32% of the control group, and the difference showed statistical meaning(P <0.05). The difference was statistically significant in the comparisons of TCM syndrome integrals, FBG, IR, BMI, waistline, TC, TG, HDL-C and LDL-C between before and after treating within the group(P<0.05); the difference showed statistical meaning in the comparisons between both groups after treating(P <0.05). There was a significant difference in the comparisons of systolic pressure, diastolic pressure and BUA between before and after treating within the group(P <0.05); the difference had no statistical meaning in the comparisons between both groups after treating(P>0.05). Conclusion: PingChen decoction is effective in clinical intervention for the patients with type two prediabetes of spleen deficiency phlegm damp pattern, it could improve clinical symptoms and the related indexes of IR, and delay further progress of impaired glucose regulation(IGR) into type two diabetes mellitus.
引文
[1]中华医学会内分泌学分会.中国成人2型糖尿病预防的专家共识[J].中华内分泌代谢杂志,2014,30(4):277-283.
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[8]袁朵.糖消汤联合生活方式干预痰湿体质超重、肥胖IGT患者的临床观察[D].武汉:湖北中医药大学,2012.
[9]庞国明,闫镛,朱璞,等.糖调节受损者的主要中医体质类型及其与相关指标的关系[J].中华中医药杂志2009,24(12):1547-1551.
[10]王琦.中医体质学[M].北京:中国医药科技出版社,1995:96-195.
[11]颜爱群.从脾论治糖耐量低减的疗效观察[J].国际医药卫生导报,2006,12(16):63-64.
[2]Wang L,Gao P,Zhang M,et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in2013[J].Jama,2017,317(24):2515-2523.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,30(10):447-498.
[4]中国肥胖问题工作组.中国成人超重与肥胖症预防与控制指南(节录)[J].营养学报,2004,26(1):1-4.
[5]中华中医药学会.糖尿病中医防治指南[J].中国中医药现代远程教育,2007,9(4):151-153.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:233.
[7]Qian Q,Zhang Z,Orwig A,et al.Snitrosoglutathione reductase dysfunction contributes to obesity-Associated hepatic insulin resistance via regulating autophagy[J].Diabetes,2017:170-223.
[8]袁朵.糖消汤联合生活方式干预痰湿体质超重、肥胖IGT患者的临床观察[D].武汉:湖北中医药大学,2012.
[9]庞国明,闫镛,朱璞,等.糖调节受损者的主要中医体质类型及其与相关指标的关系[J].中华中医药杂志2009,24(12):1547-1551.
[10]王琦.中医体质学[M].北京:中国医药科技出版社,1995:96-195.
[11]颜爱群.从脾论治糖耐量低减的疗效观察[J].国际医药卫生导报,2006,12(16):63-64.