糖皮质激素联合扩血管药物治疗突发性耳聋临床观察
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摘要
目的研究糖皮质激素联合扩血管药物用于突发性耳聋治疗中的临床效果。方法选择三门峡市中心医院2016年4月—2018年5月收治的80例突发性耳聋患者进行研究,按照患者接受治疗的不同方式进行分组,观察组40例应用糖皮质激素甲泼尼龙联合扩血管药物前列地尔治疗,对照组40例仅接受糖皮质激素甲泼尼龙治疗,比较两组临床治疗效果。结果观察组治疗结束后患者眩晕消除率、耳鸣消除率为85%、90%,均明显高于对照组(67.5%、62.5%),P<0.05;观察组治疗后疗效总有效率为87.50%,明显高于对照组(70%),P<0.05;观察组治疗后低频为(40.45±2.37)分贝,明显低于对照组治疗后,P<0.05;观察组治疗后高频听力阈值为(48.27±3.02)分贝,与对照组治疗后(41.56±5.07)分贝差异不大,P>0.05。结论糖皮质激素联合扩血管药物治疗突发性耳聋效果明显,甲泼尼龙联合前列地尔用于治疗中能够更迅速改善患者症状,提升患者听力,值得临床推广。
Objective To study the clinical effect of glucocorticoid combined with vasodilator in the treatment of sudden deafness.Methods From April 2016-2018 of 80 sudden deafness patients admitted in May, according to different ways to group of patients receiving treatment, observation group 40 cases with application of glucocorticoid armour prednisolone expand vascular drugs lead to treatment, control group 40 cases only accept glucocorticoid prednisolone treatment, compared two groups of clinical therapeutic effect.Results After treatment, the elimination rate of vertigo and tinnitus in the observation group was 85% and 90%, both significantly higher than that in the control group(67.5% and 62.5%), P<0.05. The total effective rate of treatment in the observation group was 87.50%, significantly higher than that in the control group(70%), P<0.05. The low frequency of the observation group after treatment was(40.45±2.37) db, which was significantly lower than that of the control group after treatment(40.75±5.33) db, P<0.05. After treatment, the high-frequency hearing threshold of the observation group was(48.27±3.02) db, which was not significantly different from the control group(41.56±5.07) db, P>0.05.Conclusion Glucocorticoid combined with vasodilator is effective in the treatment of sudden deafness, and methylprednisolone combined with alprostol in the treatment can rapidly improve the symptoms of patients and improve their hearing, which is worthy of clinical promotion.
Objective To study the clinical effect of glucocorticoid combined with vasodilator in the treatment of sudden deafness.Methods From April 2016-2018 of 80 sudden deafness patients admitted in May, according to different ways to group of patients receiving treatment, observation group 40 cases with application of glucocorticoid armour prednisolone expand vascular drugs lead to treatment, control group 40 cases only accept glucocorticoid prednisolone treatment, compared two groups of clinical therapeutic effect.Results After treatment, the elimination rate of vertigo and tinnitus in the observation group was 85% and 90%, both significantly higher than that in the control group(67.5% and 62.5%), P<0.05. The total effective rate of treatment in the observation group was 87.50%, significantly higher than that in the control group(70%), P<0.05. The low frequency of the observation group after treatment was(40.45±2.37) db, which was significantly lower than that of the control group after treatment(40.75±5.33) db, P<0.05. After treatment, the high-frequency hearing threshold of the observation group was(48.27±3.02) db, which was not significantly different from the control group(41.56±5.07) db, P>0.05.Conclusion Glucocorticoid combined with vasodilator is effective in the treatment of sudden deafness, and methylprednisolone combined with alprostol in the treatment can rapidly improve the symptoms of patients and improve their hearing, which is worthy of clinical promotion.
引文
[1] 李淦峰,李志海.巴曲酶联合银杏达莫注射液治疗突发性耳聋的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(8):675-677.
[2] 陈晓华,秦兆冰.地塞米松与甲泼尼龙治疗突发性耳聋的临床疗效对比[J].中国继续医学教育,2016,8(15):170-171.
[3] 王丽平,李中明,徐沙丽.高压氧联合法舒地尔注射液治疗突发性耳聋的疗效观察[J].神经损伤与功能重建,2016,11(5):451-453.
[4] 王洪波,常艳,蒋丽艳.银杏叶提取物注射液治疗突发性耳聋的临床研究[J].中国临床药理学杂志,2016,32(21):1946-1949.
[5] 张慧平,屈永涛,王荣国,等.高压氧联合鼓室灌注激素治疗突发性耳聋的疗效及对血液流变学的影响[J].中国老年学,2016,36(19):4863-4865.
[6] 易涛,范周洪.耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效[J].临床合理用药杂志,2016,9(15):72-73.
[7] 徐隽彦,刘春丽,倪丽群.前列地尔注射液治疗突发性耳聋的临床疗效及预后分析[J].浙江创伤外科,2016,21(1):86-88.
[8] 郑逸品,张建华.突发性耳聋患者治疗中出现听力损失加重的病因分析[J].临床和实验医学杂志,2016,15(20):2034-2037.
[9] 耿萍,陈亚权.鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效对比研究[J].现代药物与临床,2017,32(6):1105-1108.
[10] 李琳,闫振坤,盛敬伊,等.老年糖尿病对突发性耳聋综合治疗的负向调节作用[J].中国老年学杂志,2016,36(12):2929-2930.
[11] 陶静,王小飞,丁莉.耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效[J].中国现代医生,2017,55(4):71-73.
[12] 班正锋.甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋的疗效观察[J].医学临床研究,2017,34(1):171-173.
[2] 陈晓华,秦兆冰.地塞米松与甲泼尼龙治疗突发性耳聋的临床疗效对比[J].中国继续医学教育,2016,8(15):170-171.
[3] 王丽平,李中明,徐沙丽.高压氧联合法舒地尔注射液治疗突发性耳聋的疗效观察[J].神经损伤与功能重建,2016,11(5):451-453.
[4] 王洪波,常艳,蒋丽艳.银杏叶提取物注射液治疗突发性耳聋的临床研究[J].中国临床药理学杂志,2016,32(21):1946-1949.
[5] 张慧平,屈永涛,王荣国,等.高压氧联合鼓室灌注激素治疗突发性耳聋的疗效及对血液流变学的影响[J].中国老年学,2016,36(19):4863-4865.
[6] 易涛,范周洪.耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效[J].临床合理用药杂志,2016,9(15):72-73.
[7] 徐隽彦,刘春丽,倪丽群.前列地尔注射液治疗突发性耳聋的临床疗效及预后分析[J].浙江创伤外科,2016,21(1):86-88.
[8] 郑逸品,张建华.突发性耳聋患者治疗中出现听力损失加重的病因分析[J].临床和实验医学杂志,2016,15(20):2034-2037.
[9] 耿萍,陈亚权.鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋的疗效对比研究[J].现代药物与临床,2017,32(6):1105-1108.
[10] 李琳,闫振坤,盛敬伊,等.老年糖尿病对突发性耳聋综合治疗的负向调节作用[J].中国老年学杂志,2016,36(12):2929-2930.
[11] 陶静,王小飞,丁莉.耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效[J].中国现代医生,2017,55(4):71-73.
[12] 班正锋.甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋的疗效观察[J].医学临床研究,2017,34(1):171-173.