酪酸梭菌活菌胶囊治疗腹泻型肠易激综合征的临床观察
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摘要
目的评价酪酸梭菌活菌胶囊治疗腹泻型肠易激综合征的临床疗效。方法选择2015年8月—2017年5月我院收治的腹泻型肠易激综合征60例,按照随机数字表法分为2组。其中对照组30例口服匹维溴铵,观察组30例患者酪酸梭菌活菌胶囊联合匹维溴铵治疗。结果治疗后,观察组腹痛/腹部不适、大便次数异常、形状异常、排便异常及粘液便评分均较前下降,观察组各项评分均低于对照组,差异有统计学意义(P<0.05)。观察组痊愈13例、显效14例、有效3例,临床效果优于对照组痊愈4例、显效15例、有效11例,差异有统计学意义(P<0.05)。结论酪酸梭菌活菌胶囊可改善腹泻型肠易激综合征肠道功能,提供临床效果。
Objective To discuss the clinical curative effect of clostridum butyricum capsule in treating diarrhea predominant irritable bowel syndrome. Methods 60 cases of diarrhea predominant irritable bowel syndrome from August 2015 to May 2017 were selected and divided into two groups according to the random number table method. There were 30 patients in control group treated with pinaverium bromide, 30 patients in the observation group treated with clostridum butyricum capsule combined with pinaverium bromide. Results After treatment, the scores of abdominal pain/abdominal discomfort, abnormal stool times, abnormal shape, abnormal bowel movement and mucus stool score in observation group were lower than those in the control group(P < 0.05). In the observation group, 13 cases were cured, 14 cases were markedly effective and 3 cases were effective. The clinical effect was better than that of the control group, 4 cases were cured, 15 cases were markedly effective and 11 cases were effective, the difference was statistically significant(P < 0.05). Conclusion Clostridum butyricum capsule can significantly improve diarrhea predominant irritable bowel syndrome with intestinal function and the clinical effect is obvious.
Objective To discuss the clinical curative effect of clostridum butyricum capsule in treating diarrhea predominant irritable bowel syndrome. Methods 60 cases of diarrhea predominant irritable bowel syndrome from August 2015 to May 2017 were selected and divided into two groups according to the random number table method. There were 30 patients in control group treated with pinaverium bromide, 30 patients in the observation group treated with clostridum butyricum capsule combined with pinaverium bromide. Results After treatment, the scores of abdominal pain/abdominal discomfort, abnormal stool times, abnormal shape, abnormal bowel movement and mucus stool score in observation group were lower than those in the control group(P < 0.05). In the observation group, 13 cases were cured, 14 cases were markedly effective and 3 cases were effective. The clinical effect was better than that of the control group, 4 cases were cured, 15 cases were markedly effective and 11 cases were effective, the difference was statistically significant(P < 0.05). Conclusion Clostridum butyricum capsule can significantly improve diarrhea predominant irritable bowel syndrome with intestinal function and the clinical effect is obvious.
引文
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[9]马辉,唐帆,侯吉学,等.酪酸梭菌联合抗菌药物对急性阑尾炎患者腹腔镜术后炎症因子及胃肠功能的影响[J].中国药房,2017,28(35):4978-4980.
[10]林刻智,赵娜,孔咪咪,等.酪酸梭菌预防小鼠幽门结扎型胃溃疡的机制研究[J].中国病理生理杂志,2015,31(7):1309-1314.
[11]王强.醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻的研究[J].现代中西医结合杂志,2015,24(2):170-172.
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[2]夏永红,苏信云.美沙拉嗪联合马来酸曲美布汀治疗腹泻型肠易激综合征疗效观察[J].中国基层医药,2018,25(3):368-371.
[3]陈飞,周雪莲.氟哌噻吨美利曲辛和匹维溴铵联合治疗肠易激综合征的疗效[J].中国生化药物杂志,2016,36(4):86-88.
[4]庄莹,林志辉.27例腹泻型肠易激综合征患者食物不耐受与结肠黏膜肥大细胞、P物质含量的相关性[J].中华消化杂志,2016,36(2):91-95.
[5]许晓娟,刘亮,姚树坤,等.腹泻型肠易激综合征患者内脏敏感性、肠屏障功能及自主神经功能的评价[J].中南大学学报(医学版),2017,42(5):522-528.
[6]江学良.益生菌临床应用的共识与实践[J].中华消化病与影像杂志(电子版),2016,6(4):145-149.
[7]于杰.酪酸梭菌活菌片治疗腹泻型肠易激综合征的临床疗效[J].中国微生态学杂志,2015,27(7):802-804.
[8]江学良,姜开通,许刚.酪酸梭菌活菌胶囊治疗腹泻型肠易激综合征的临床疗效及卫生经济学评价[J].中国微生态学杂志,2016,28(9):1075-1079.
[9]马辉,唐帆,侯吉学,等.酪酸梭菌联合抗菌药物对急性阑尾炎患者腹腔镜术后炎症因子及胃肠功能的影响[J].中国药房,2017,28(35):4978-4980.
[10]林刻智,赵娜,孔咪咪,等.酪酸梭菌预防小鼠幽门结扎型胃溃疡的机制研究[J].中国病理生理杂志,2015,31(7):1309-1314.
[11]王强.醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻的研究[J].现代中西医结合杂志,2015,24(2):170-172.
[12]何江进.补脾益肠丸联合酪酸梭菌活菌胶囊治疗腹泻型肠易激综合征临床观察[J].新中医,2017,49(6):44-46.