肠道微生态在急性胰腺炎发病和治疗中的应用研究进展
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摘要
急性胰腺炎是临床常见的急性危重症疾病之一,引发该疾病发生的致病因素有多种,如酒精因素、感染因素、梗阻因素以及肠道微生态因素等,其中,在疾病发生和发展过程中,各种内毒素、细胞体液因子等介质促使肠腔内细菌及毒素移位、肠壁通透性增高均可诱发感染,不仅会对患者其他脏器功能产生损害,同时,也是导致急性胰腺炎患者死亡的第二原因,可见肠道微生态平衡与急性胰腺炎发病、病情发展均有密切关联。本文主要简述了急性胰腺炎与肠道微生态的概念,分析了肠道微生态对急性胰腺炎发病的影响,并对肠道微生态在急性胰腺炎治疗中的应用进展进行了总结,以期能为后续临床提供有效的参考。
Acute pancreatitis is one of common acute and critical diseases in clinical practice, with pathogenic factors of alcohol, infection, obstruction and intestinal microecological factors etc. Duing process of disease occurrence and development, various endotoxins, cytohumoral factors and other mediators promote translocation of bacteria and toxins in intestinal cavity, and increase of intestinal wall permeability, which may induce infection, impairs other organ functions of patients, and is the second death cause of acute pancreatitis. It can be seen that intestinal microecological balance is closely related to onset and development of acute pancreatitis. The paper introduces concept of acute pancreatitis and intestinal microecology briefly, analyzes effect of intestinal microecology on pathogenesis of acute pancreatitis, and summarizes application progress of intestinal microecology in treatment of acute pancreatitis, to provide effective reference for follow-up clinical practice.
Acute pancreatitis is one of common acute and critical diseases in clinical practice, with pathogenic factors of alcohol, infection, obstruction and intestinal microecological factors etc. Duing process of disease occurrence and development, various endotoxins, cytohumoral factors and other mediators promote translocation of bacteria and toxins in intestinal cavity, and increase of intestinal wall permeability, which may induce infection, impairs other organ functions of patients, and is the second death cause of acute pancreatitis. It can be seen that intestinal microecological balance is closely related to onset and development of acute pancreatitis. The paper introduces concept of acute pancreatitis and intestinal microecology briefly, analyzes effect of intestinal microecology on pathogenesis of acute pancreatitis, and summarizes application progress of intestinal microecology in treatment of acute pancreatitis, to provide effective reference for follow-up clinical practice.
引文
[1]仓晓凤,万荣.肠道微生态与胰腺疾病[J].现代消化及介入诊疗,2017,22(01):160-162.
[2]王凯,周仁正,宫健康.益生菌联合早期肠内营养对重症急性胰腺炎患者血清炎性因子水平的影响研究[J].川北医学院学报,2018,33(06):888-890+902.
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[4]朱毅东,史和平,吴云龙.清热解毒通里攻下法辅助西医治疗重症急性胰腺炎疗效及对炎性细胞因子、肠道微生态的影响[J].现代中西医结合杂志,2018,27(28):3098-3101+3105.
[5]李山林,刘学进,周洪涛,等.益生菌与血必净联合治疗重症急性胰腺炎效果分析[J].现代医药卫生,2018,34(16):2528-2530.
[6]莫雅娴,黄波.益生菌联合早期肠内营养治疗重症急性胰腺炎[J].中国城乡企业卫生,2017,32(08):104-106.
[7]蒋杨峥,谢红.早期肠内营养支持在急性重症胰腺炎治疗中的应用研究[J].世界最新医学信息文摘,2018,18(48):67+69.
[8]张远军.益生菌联合早期肠内营养治疗重症急性胰腺炎的临床观察[J].实用临床医药杂志,2018,22(09):124-125+128.
[9]尹蓉,陈渝萍.重症急性胰腺炎应用益生菌肠内营养治疗的临床效果分析[J].临床医学工程,2017,24(11):1551-1552.
[10]LiQ,WangC,TangC,etal.Bacteremia in patients with acute pancreatitis as revealed by 16S ribosomal RNA genebased techniques[J].Crit Care Med,2013,41(8):1938-1950.
[11]王兴鹏,曾悦.肠道微生态在急性胰腺炎发病和治疗中的研究进展[J].中华消化杂志,2016,36(10):658-661.
[12]TanC,LingZ,HuangY,etal.Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis[J].Pancreas,2015,44(6):868-875.
[13]尹玉花.早期肠内营养联合益生菌对重症急性胰腺炎患者的疗效[J].临床医药文献电子杂志,2016,3(18):3703-3704.
[14]周翔,夏先明.肠道微生态与胰腺炎的研究进展[J].世界华人消化杂志,2016,24(02):222-228.
[15]刘宁,郭伟强,潘美云.早期联合应用肠内营养及益生菌辅助治疗重症急性胰腺炎的临床疗效[J].世界华人消化杂志,2015,23(36):5875-5881.
[16]袁本权.早期肠内营养支持在急性重症胰腺炎治疗中的应用价值分析[J].中外医学研究,2019,17(02):148-150.
[17]赫为,倪海伦.早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响[J].中国食物与营养,2018,24(06):64-67.
[18]卢世云,林志辉,潘秀珍.益生菌治疗重症急性胰腺炎的临床效果[J].中国微生态学杂志,2015,27(10):1170-1173.
[19]胡炜,刘洪斌,王曼雪,等.清胰汤和姜黄素调整肠道微生态对重症急性胰腺炎的治疗机制[J].天津医药,2018,46(11):1155-1160.
[20]黄强业,梁开坚,王齐全,等.肠内营养+双歧杆菌三联活菌散对重症急性胰腺炎患者疗效的影响[J].现代消化及介入诊疗,2015,20(06):663-665.
[21]董文舒,范旻,姚俊英,等.益生菌肠内营养治疗重症急性胰腺炎临床效果分析[J].现代医药卫生,2014,30(05):664-665+667.
[2]王凯,周仁正,宫健康.益生菌联合早期肠内营养对重症急性胰腺炎患者血清炎性因子水平的影响研究[J].川北医学院学报,2018,33(06):888-890+902.
[3]HanT,LiXL,CaiDL,etal.Effects of glutamine-supplemented enteral or parenteral nutrition on apoptosis of intestinal mucosal cells in rats with severe acute pancreatitis[J].Eur Rev MedPharmacol Sci,2013,17(11):1529-1535.
[4]朱毅东,史和平,吴云龙.清热解毒通里攻下法辅助西医治疗重症急性胰腺炎疗效及对炎性细胞因子、肠道微生态的影响[J].现代中西医结合杂志,2018,27(28):3098-3101+3105.
[5]李山林,刘学进,周洪涛,等.益生菌与血必净联合治疗重症急性胰腺炎效果分析[J].现代医药卫生,2018,34(16):2528-2530.
[6]莫雅娴,黄波.益生菌联合早期肠内营养治疗重症急性胰腺炎[J].中国城乡企业卫生,2017,32(08):104-106.
[7]蒋杨峥,谢红.早期肠内营养支持在急性重症胰腺炎治疗中的应用研究[J].世界最新医学信息文摘,2018,18(48):67+69.
[8]张远军.益生菌联合早期肠内营养治疗重症急性胰腺炎的临床观察[J].实用临床医药杂志,2018,22(09):124-125+128.
[9]尹蓉,陈渝萍.重症急性胰腺炎应用益生菌肠内营养治疗的临床效果分析[J].临床医学工程,2017,24(11):1551-1552.
[10]LiQ,WangC,TangC,etal.Bacteremia in patients with acute pancreatitis as revealed by 16S ribosomal RNA genebased techniques[J].Crit Care Med,2013,41(8):1938-1950.
[11]王兴鹏,曾悦.肠道微生态在急性胰腺炎发病和治疗中的研究进展[J].中华消化杂志,2016,36(10):658-661.
[12]TanC,LingZ,HuangY,etal.Dysbiosis of intestinal microbiota associated with inflammation involved in the progression of acute pancreatitis[J].Pancreas,2015,44(6):868-875.
[13]尹玉花.早期肠内营养联合益生菌对重症急性胰腺炎患者的疗效[J].临床医药文献电子杂志,2016,3(18):3703-3704.
[14]周翔,夏先明.肠道微生态与胰腺炎的研究进展[J].世界华人消化杂志,2016,24(02):222-228.
[15]刘宁,郭伟强,潘美云.早期联合应用肠内营养及益生菌辅助治疗重症急性胰腺炎的临床疗效[J].世界华人消化杂志,2015,23(36):5875-5881.
[16]袁本权.早期肠内营养支持在急性重症胰腺炎治疗中的应用价值分析[J].中外医学研究,2019,17(02):148-150.
[17]赫为,倪海伦.早期肠内营养加微生态制剂对重症急性胰腺炎患者疗效的影响[J].中国食物与营养,2018,24(06):64-67.
[18]卢世云,林志辉,潘秀珍.益生菌治疗重症急性胰腺炎的临床效果[J].中国微生态学杂志,2015,27(10):1170-1173.
[19]胡炜,刘洪斌,王曼雪,等.清胰汤和姜黄素调整肠道微生态对重症急性胰腺炎的治疗机制[J].天津医药,2018,46(11):1155-1160.
[20]黄强业,梁开坚,王齐全,等.肠内营养+双歧杆菌三联活菌散对重症急性胰腺炎患者疗效的影响[J].现代消化及介入诊疗,2015,20(06):663-665.
[21]董文舒,范旻,姚俊英,等.益生菌肠内营养治疗重症急性胰腺炎临床效果分析[J].现代医药卫生,2014,30(05):664-665+667.