特布他林辅助阿奇霉素序贯治疗小儿支原体肺炎的效果及对气道功能的影响
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摘要
目的探讨特布他林辅助阿奇霉素序贯治疗对小儿支原体肺炎的效果及气道功能的影响。方法将我院96例支原体肺炎患儿按随机数表法分为观察组(采用特布他林辅助阿奇霉素序贯治疗)与对照组(采用阿奇霉素序贯治疗),各48例。对比两组临床疗效、气道功能及不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组患者FEV1、FEV1/FVC、PEF、FEF25%均显著升高,且观察组均明显高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论特布他林辅助阿奇霉素序贯治疗小儿支原体肺炎疗效显著,可明显改善患儿气道功能,且不良反应并未明显增加,具有较好的临床应用价值。
Objective To investigate the effect of terbutaline-assisted azithromycin sequential therapy in children with mycoplasma pneumonia and the influence on airway function. Methods Ninety-six children with mycoplasma pneumonia in our hospital were divided into observation group(treated with terbutaline-assisted azithromycin sequential therapy) and control group(treated with azithromycin sequential therapy) by random number table method, with 48 cases in each group.The clinical efficacy, airway function and incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group(P <0.05). After treatment, the FEV1, FEV1/FVC, PEF and FEF25% of the two groups significantly increased, and those of the observation group were significantly higher than the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P >0.05). Conclusion Terbutaline-assisted azithromycin sequential therapy in children with mycoplasma pneumonia has a significant effect, which can obviously improve the airway function of children,and has less adverse reactions. It has better clinical value.
Objective To investigate the effect of terbutaline-assisted azithromycin sequential therapy in children with mycoplasma pneumonia and the influence on airway function. Methods Ninety-six children with mycoplasma pneumonia in our hospital were divided into observation group(treated with terbutaline-assisted azithromycin sequential therapy) and control group(treated with azithromycin sequential therapy) by random number table method, with 48 cases in each group.The clinical efficacy, airway function and incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group(P <0.05). After treatment, the FEV1, FEV1/FVC, PEF and FEF25% of the two groups significantly increased, and those of the observation group were significantly higher than the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P >0.05). Conclusion Terbutaline-assisted azithromycin sequential therapy in children with mycoplasma pneumonia has a significant effect, which can obviously improve the airway function of children,and has less adverse reactions. It has better clinical value.
引文
[1]肖佩玉,曲彩虹,庄华玲.阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及安全性分析[J].中国妇幼健康研究,2016,27(s1):232.
[2]郑静,宋闻.阿奇霉素联合特布他林和布地奈德治疗小儿支原体肺炎的临床研究[J].中国妇幼保健,2016,31(13):2655-2657.
[3]中华医学会儿科学分会呼吸学组.儿童肺炎支原体肺炎诊治专家共识(2015版)[J].中华实用儿科临床杂志,2015,30(17):1304-1308.
[4]杜晓宁,梁丽霞,严慧芳,等.阿奇霉素序贯疗法联合特步他林治疗小儿支原体肺炎的临床观察[J].中国药房,2016,27(6):740-742.
[5]梅江华.阿奇霉素序贯疗法联合小儿肺热咳喘口服液治疗肺炎支原体肺炎患儿45例临床观察[J].中国药物与临床,2016,16(8):1197-1198.
[6]吴百平.阿奇霉素序贯疗法对小儿支原体肺炎炎性因子及体液免疫功能调节的影响[J].医学综述,2015,29(19):3628-3630.
[7]史巍.布地奈德联合硫酸特布他林雾化吸入治疗支气管哮喘的有效性探究[J].山西医药杂志,2015,44(22):2671-2673.
[8]熊星.阿奇霉素联合特步他林雾化吸入治疗小儿支原体肺炎的临床疗效[J].湖南中医药大学学报,2016,36(a2):729-730.
[9]鱼建飞,梅玲华,贺兆平.特布他林辅助阿奇霉素序贯治疗小儿肺炎的疗效及其对患儿气道炎症因子的影响[J].海南医学,2017,28(1):73-76.
[10]裴新昕.阿奇霉素、特布他林、孟鲁司特联用对咳嗽变异性哮喘合并感染患儿气道功能及感染程度的影响[J].海南医学院学报,2016,22(18):2167-2170.
[2]郑静,宋闻.阿奇霉素联合特布他林和布地奈德治疗小儿支原体肺炎的临床研究[J].中国妇幼保健,2016,31(13):2655-2657.
[3]中华医学会儿科学分会呼吸学组.儿童肺炎支原体肺炎诊治专家共识(2015版)[J].中华实用儿科临床杂志,2015,30(17):1304-1308.
[4]杜晓宁,梁丽霞,严慧芳,等.阿奇霉素序贯疗法联合特步他林治疗小儿支原体肺炎的临床观察[J].中国药房,2016,27(6):740-742.
[5]梅江华.阿奇霉素序贯疗法联合小儿肺热咳喘口服液治疗肺炎支原体肺炎患儿45例临床观察[J].中国药物与临床,2016,16(8):1197-1198.
[6]吴百平.阿奇霉素序贯疗法对小儿支原体肺炎炎性因子及体液免疫功能调节的影响[J].医学综述,2015,29(19):3628-3630.
[7]史巍.布地奈德联合硫酸特布他林雾化吸入治疗支气管哮喘的有效性探究[J].山西医药杂志,2015,44(22):2671-2673.
[8]熊星.阿奇霉素联合特步他林雾化吸入治疗小儿支原体肺炎的临床疗效[J].湖南中医药大学学报,2016,36(a2):729-730.
[9]鱼建飞,梅玲华,贺兆平.特布他林辅助阿奇霉素序贯治疗小儿肺炎的疗效及其对患儿气道炎症因子的影响[J].海南医学,2017,28(1):73-76.
[10]裴新昕.阿奇霉素、特布他林、孟鲁司特联用对咳嗽变异性哮喘合并感染患儿气道功能及感染程度的影响[J].海南医学院学报,2016,22(18):2167-2170.