高通血液透析与血液透析滤过对改善尿毒症患者不宁腿和高血压的效果
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摘要
目的:比较高通量血液透析和血液透析滤过联合常规低通透析对改善不宁腿综合征和高血压的效果。方法:选取患者40人随机分成两组,每组20人,HFHD组高通量血液透析,HDF组血液透析滤过联合低通血液透析治疗,治疗6个月,比较两组患者治疗前后中分子毒素β2-微球蛋白的水平,血压情况和不宁腿有效率。结果:两组患者治疗前后β2-微球蛋白水平,血压水平均下降,有统计学差异,治疗后两组β2-微球蛋白,无统计学差异,HFHD组患者血压下降率,不宁腿综合征有效率优于HDF组,且有统计学差异。结论:两组患者治疗后β2-微球蛋白下降率无明显差异,但HFHD组患者血压下降的有效率,改善不宁腿综合征有效率优于HDF组。
Objective: To compare the effects of high Permeability hemodialysis and hemodialysis filtration combined with conventional low-pass dialysis on the improvement of Unstable Leg syndrome and hypertension. Methods: Select 40 patients and randomly divide them into two groups of 20 people. High-throughput hemodialysis in HFHD group,hemodialysis filtration in HDF group combined with low-pass hemodialysis,treatment for 6 months. To compare the efficiency of molecular toxin β2-microglobulin,blood pressure and unstable leg syndrome in two groups. Results: Theβ2-microglobulin levels and blood pressure levels of the two groups of patients were reduced before and after treatment,which was statistically significant. After the treatment,there was no statistical difference between the two groups of β2-microglobulin. Blood pressure drop rate in HFHD group,unstable leg syndrome is more efficient than HDF group,and there's a statistical difference. Conclusion: There was no significant difference in the rate of decrease of β2-microglobulin after treatment between the two groups,but the rate of blood pressure decreasing and unstable leg syndrome in HFHD group was more effective than that of HDF group.
Objective: To compare the effects of high Permeability hemodialysis and hemodialysis filtration combined with conventional low-pass dialysis on the improvement of Unstable Leg syndrome and hypertension. Methods: Select 40 patients and randomly divide them into two groups of 20 people. High-throughput hemodialysis in HFHD group,hemodialysis filtration in HDF group combined with low-pass hemodialysis,treatment for 6 months. To compare the efficiency of molecular toxin β2-microglobulin,blood pressure and unstable leg syndrome in two groups. Results: Theβ2-microglobulin levels and blood pressure levels of the two groups of patients were reduced before and after treatment,which was statistically significant. After the treatment,there was no statistical difference between the two groups of β2-microglobulin. Blood pressure drop rate in HFHD group,unstable leg syndrome is more efficient than HDF group,and there's a statistical difference. Conclusion: There was no significant difference in the rate of decrease of β2-microglobulin after treatment between the two groups,but the rate of blood pressure decreasing and unstable leg syndrome in HFHD group was more effective than that of HDF group.
引文
[1]王雪娜.高通量血液透析与血液透析滤过对慢性肾衰竭尿毒症患者的透析效果比较[J].中国现代药物应用,2017,11(19):61-62.
[2]王霞.高通量血液透析和血液透析滤过治疗尿毒症效果的比较研究[J].中国民康医学,2016,11(22):18-19.
[3]林小洁,王铠.不同血液净化方式对β2微球蛋白清除效果的比较[J].北京医学,2016,08(38):829-832.
[4]赵进,邱川红,蔡伟.不同血液净化方法对39例维持性血液透析并难治性高血压患者的疗效观察[J].西部医学,2011,23(2):296-297.
[5] Inrig J K,Patel UD,Toto RD,et al. Association of Blood Pressure Increases During Hemodialysis With 2-Year Mortality in Incident Hemodialysis Patients:A Secondary Analysis of the Dialysis Morbidity and Mortality Wave2Study[J]. Am J Kidney Dis,2009,(54):881-890.
[2]王霞.高通量血液透析和血液透析滤过治疗尿毒症效果的比较研究[J].中国民康医学,2016,11(22):18-19.
[3]林小洁,王铠.不同血液净化方式对β2微球蛋白清除效果的比较[J].北京医学,2016,08(38):829-832.
[4]赵进,邱川红,蔡伟.不同血液净化方法对39例维持性血液透析并难治性高血压患者的疗效观察[J].西部医学,2011,23(2):296-297.
[5] Inrig J K,Patel UD,Toto RD,et al. Association of Blood Pressure Increases During Hemodialysis With 2-Year Mortality in Incident Hemodialysis Patients:A Secondary Analysis of the Dialysis Morbidity and Mortality Wave2Study[J]. Am J Kidney Dis,2009,(54):881-890.