利培酮联合认知行为治疗精神分裂症残留型症状的疗效观察
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摘要
目的:观察利培酮联合认知行为治疗精神分裂症残留型症状的疗效。方法:将84例精神分裂症的患者随机分为两组,每组42例,观察组采用利培酮联合认知行为治疗,对照组单纯利培酮治疗,采用阳性与阴性症状量表(PANSS)和精神分裂症认知功能成套检测共识版量表(MCCB),对两组患者治疗前后的评分进行评定。结果:两组阴性症状评分治疗前、后比较差异具有统计学意义,观察组阴性症状评分治疗前、后组内比较,差异具有统计学意义(P<0.05),两组之间其他量表评分比较,差异不具有统计学意义(P>0.05)。在认知功能方面,治疗后观察组患者在语意流畅、视觉记忆、言语记忆、情绪管理、持续操作方面评分低于对照组,组间差异具有统计学意义(P<0.05)。结论:采用利培酮联合认知行为治疗精神分裂症残留型症状优于单纯利培酮治疗效果。
Objective: To investigate therapeutic effects of Rrisperidone combined with cognitive behavior therapy on residual symptoms of schizophrenia.Methods: Eighty-four patients with schizophrenia were divided into two groups(n = 42) according to the admission order.The observation group was treated with Risperidone combined with cognitive behavior,while the control group was treated with Risperidone alone.The positive and negative symptom scale(PANSS) and MATRICS consensus cognitive battery(MCCB) were used to assess the effects.Results: There were no statistical differences in the negative symptom score between the two groups before and after the treatment; however,there was a statistical difference in the negative symptom score in the observation group before and after the treatment(P<0.05).There were no statistical differences in other scores between the two groups(P>0.05).In the cognitive function,the scores of semantic fluency visual memory,verbal memory,emotional management and continuous operation of the observation group after the treatment were lower than those of the control group,and the differences were statistically significant(P< 0.05).Conclusions: The combination of Risperidone and cognitive behavior in the treatment of residual schizophrenia has more obvious clinical effects than single Risperidone.
Objective: To investigate therapeutic effects of Rrisperidone combined with cognitive behavior therapy on residual symptoms of schizophrenia.Methods: Eighty-four patients with schizophrenia were divided into two groups(n = 42) according to the admission order.The observation group was treated with Risperidone combined with cognitive behavior,while the control group was treated with Risperidone alone.The positive and negative symptom scale(PANSS) and MATRICS consensus cognitive battery(MCCB) were used to assess the effects.Results: There were no statistical differences in the negative symptom score between the two groups before and after the treatment; however,there was a statistical difference in the negative symptom score in the observation group before and after the treatment(P<0.05).There were no statistical differences in other scores between the two groups(P>0.05).In the cognitive function,the scores of semantic fluency visual memory,verbal memory,emotional management and continuous operation of the observation group after the treatment were lower than those of the control group,and the differences were statistically significant(P< 0.05).Conclusions: The combination of Risperidone and cognitive behavior in the treatment of residual schizophrenia has more obvious clinical effects than single Risperidone.
引文
[1]程进博,笈彤宇,王岩.利培酮联合认知行为治疗精神分裂症残留型症状的效果[J].广东医学,2015,52(5):782-784.
[2]金丽娜.利培酮联合认知行为治疗精神分裂症残留型症状的效果观察[J].医药前沿,2016,6(23):113.
[3]王永良.认知行为与利培酮联合治疗精神分裂症残留型的临床疗效分析[J].中国卫生标准管理,2015,6(24):100-101.
[4]黄磊,钱建军,田国强.不同药物联合利培酮及认知行为治疗残留型精神分裂症的疗效分析[J].中华全科医学,2016,14(11):1816-1819.
[5]李雪晶,郭轶,傅春恋.CBT联合小剂量利培酮对精神分裂症患者认知功能影响的神经心理学评估[J].四川精神卫生,2015,28(3):211-214.
[6]王飞,李红丽.利培酮联合舍曲林治疗精神分裂症强迫症状的疗效观察[J].药物流行病学杂志,2015,24(6):338-340.
[7]孙建红.舒肝解郁胶囊联合利培酮片治疗精神分裂症阴性症状的临床疗效观察[J].基层医学论坛,2016,20(s1):34-35.
[8]徐静文,刘群,应启昂.利培酮联合盐酸多奈哌齐对慢性精神分裂症认知功能的影响[J].中国药业,2015,24(24):117-119.
[2]金丽娜.利培酮联合认知行为治疗精神分裂症残留型症状的效果观察[J].医药前沿,2016,6(23):113.
[3]王永良.认知行为与利培酮联合治疗精神分裂症残留型的临床疗效分析[J].中国卫生标准管理,2015,6(24):100-101.
[4]黄磊,钱建军,田国强.不同药物联合利培酮及认知行为治疗残留型精神分裂症的疗效分析[J].中华全科医学,2016,14(11):1816-1819.
[5]李雪晶,郭轶,傅春恋.CBT联合小剂量利培酮对精神分裂症患者认知功能影响的神经心理学评估[J].四川精神卫生,2015,28(3):211-214.
[6]王飞,李红丽.利培酮联合舍曲林治疗精神分裂症强迫症状的疗效观察[J].药物流行病学杂志,2015,24(6):338-340.
[7]孙建红.舒肝解郁胶囊联合利培酮片治疗精神分裂症阴性症状的临床疗效观察[J].基层医学论坛,2016,20(s1):34-35.
[8]徐静文,刘群,应启昂.利培酮联合盐酸多奈哌齐对慢性精神分裂症认知功能的影响[J].中国药业,2015,24(24):117-119.