骨科老年患者镇痛药的应用概况及注意事项
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摘要
疼痛是骨科老年患者的常见症状,多采用镇痛药治疗。老年患者多数合并内科疾病,用药后容易出现不良反应,因此镇痛药的选择至关重要。如何在保证镇痛效果的同时减少不良反应,是临床治疗的关键。本文对骨科老年患者镇痛药的应用概况及注意事项进行了综述。
引文
[1]陈丹琼,谭晓珍,朱肖奇,等.护理干预对下肢骨折术后患者疼痛及满意度的影响[J].中国实用护理杂志,2009,25(11):32-33.
[2]李梦诗,顾申,周玲君.慢性疼痛患者疼痛功能障碍和生活满意度的影响因素分析[J].护理学报,2014,21(24):5-8.
[3]王红梅.舒适护理对上肢骨折术后患者疼痛及满意度的影响研究[J].国际护理学杂志,2013,32(4):764-765.
[4]杨群英,杨园园,陶树平,等.舒适护理对骨折患者术后疼痛及满意度的影响[J].中国实用护理杂志,2010,26(35):32-33.
[5]KAYE A D,BALUCH A R,KAYE R J,et al.Geriatric pain management,pharmacological and nonpharmacological considerations[J].Psychology and Neuroscience,2014,7(1):15-26.
[6]PIMENTEL C B,BRIESACHER B A,GURWITZ J H,et al.Pain management in nursing home residents with cancer[J].JAm Geriatr Soc,2015,63(4):633-641.
[7]PERGOLIZZI J,BGER R H,BUDD PERGOLIZZI J,et al.Opioids and the management of chronic severe pain in the elderly:consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids(buprenorphine,fentanyl,hydromorphone,methadone,morphine,oxycodone)[J].Pain Pract,2008,8(4):287-313.
[8]EISEN A,PORTER A,HOSHEN M,et al.The association between e GFR in the normal or mildly impaired range and incident cadiovascular disease:Age and sex analysis[J].Eur J Intern Med,2018,54:70-75.
[9]MODIG S,ELMSTHL S.Kidney function and use of nonsteroidal anti-inflammatory drugs among elderly people:a cross-sectional study on potential hazards for an at risk population[J].Int J Clin pharm,2018,40(4):870-877.
[10]INAFUKU T,NOZAKI H.Liver function of the most elderly patients[J].Rinsho Byori,2000,48(3):227-232.
[11]BAERWALD C,VERDECCHIA P,DUQUESROIX B,et al.Efficacy,safety,and effects on blood pressure of naproxcinod750 mg twice daily compared with placebo and naproxen 500mg twice daily in patients with osteoarthritis of the hip:a randomized,double-blind,parallel-group,multicenter study[J].Arthritis Rheum,2010,62(12):3635-3644.
[12]HUANG K C,HUANG T W,YANG T Y,et al.Chronic NSAIDs Use Increases the Risk of a Second Hip Fracture in Patients After Hip Fracture Surgery:Evidence From a STROBE-Compliant Population-Based Study[J].Medicine(Baltimore),2015,94(38):e1566.
[13]AMINOSHARIAE A,KULILD J C,DONALDSON M.Shortterm use of nonsteroidal anti-inflammatory drugs and adverse effects:An updated systematic review[J].J Am Dent Assoc,2016,147(2):98-110.
[14]老年慢性非癌痛诊疗共识编写专家组.老年慢性非癌痛药物治疗中国专家共识[J].中国疼痛医学杂志,2016,22(5):321-325.
[15]中国医师协会疼痛科医师分会,国家临床重点专科·中日医院疼痛专科医联体,北京市疼痛治疗质量控制和改进中心.慢性肌肉骨骼疼痛的药物治疗专家共识(2018)[J].中国疼痛医学杂志,2018,24(12):881-887.
[16]PERGOLIZZI J V,RAFFA R B,MARCUM Z,et al.Safety of buprenorphine transdermal system in the management of pain in older adults[J].Postgrad Med,2017,129(1):92-101.
[17]QASEEM A,WILT T J,MCLEAN R M,et al.Noninvasive Treatments for Acute,Subacute,and Chronic Low Back Pain:A Clinical Practice Guideline From the American College of Physicians[J].Ann Intern Med,2017,166(7):514-530.
[18]SRIUTTHA P,SIRICHANCHUEN B,PERMSUWAN U.Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs:ASystematic Review of Randomized Controlled Trials[J].Int J Hepatol,2018,2018:5253623.
[19]JESSURUN N,VAN PUIJENBROEK E.Relationship between structural alerts in NSAIDs and idiosyncratic hepatotoxicity:an analysis of spontaneous report data from the WHO database[J].Drug Saf,2015,38(5):511-515.
[20]BESSONE F.Non-steroidal anti-inflammatory drugs:What is the actual risk of liver damage?[J].World J Gastroenterol,2010,16(45):5651-5661.
[21]WHELTON A.Nephrotoxicity of nonsteroidal anti-inflammatory drugs:physiologic foundations and clinical implications[J].Am J Med,1999,106(5B):13S-24S.
[22]ZHANG J,DING E L,SONG Y.Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events:metaanalysis of randomized trials[J].JAMA,2006,296(13):1619-1632.
[23]Coxib and Traditional NSAID Trialists’(CNT)Collaboration,BHALA N,EMBERSON J,et al.Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs:meta-analyses of individual participant data from randomised trials[J].Lancet,2013,382(9894):769-779.
[24]RUSCHITZKA F,BORER J S,KRUM H,et al.Differential blood pressure effects of ibuprofen,naproxen,and celecoxib in patients with arthritis:the PRECISION-ABPM(Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement)Trial[J].Eur Heart J,2017,38(44):3282-3292.
[25]DAVIS M P.Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain[J].JSupport Oncol,2012,10(6):209-219.
[26]COTTRELL J,O’CONNOR J P.Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing[J].Pharmaceuticals(Basel),2010,3(5):1668-1693.
[27]BORGEAT A,OFNER C,SAPORITO A,et al.The effect of nonsteroidal anti-inflammatory drugs on bone healing in humans:A qualitative,systematic review[J].J Clin Anesth,2018,49:92-100.
[28]KURMIS A P,KURMIS T P,O’BRIEN J X,et al.The effect of nonsteroidal anti-inflammatory drug administration on acute phase fracture-healing:a review[J].J Bone Joint Surg Am,2012,94(9):815-823.
[29]ALTMAN R D,LATTA L L,KEER R,et al.Effect of nonsteroidal antiinflammatory drugs on fracture healing:a laboratory study in rats[J].J Orthop Trauma,1995,9(5):392-400.
[2]李梦诗,顾申,周玲君.慢性疼痛患者疼痛功能障碍和生活满意度的影响因素分析[J].护理学报,2014,21(24):5-8.
[3]王红梅.舒适护理对上肢骨折术后患者疼痛及满意度的影响研究[J].国际护理学杂志,2013,32(4):764-765.
[4]杨群英,杨园园,陶树平,等.舒适护理对骨折患者术后疼痛及满意度的影响[J].中国实用护理杂志,2010,26(35):32-33.
[5]KAYE A D,BALUCH A R,KAYE R J,et al.Geriatric pain management,pharmacological and nonpharmacological considerations[J].Psychology and Neuroscience,2014,7(1):15-26.
[6]PIMENTEL C B,BRIESACHER B A,GURWITZ J H,et al.Pain management in nursing home residents with cancer[J].JAm Geriatr Soc,2015,63(4):633-641.
[7]PERGOLIZZI J,BGER R H,BUDD PERGOLIZZI J,et al.Opioids and the management of chronic severe pain in the elderly:consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids(buprenorphine,fentanyl,hydromorphone,methadone,morphine,oxycodone)[J].Pain Pract,2008,8(4):287-313.
[8]EISEN A,PORTER A,HOSHEN M,et al.The association between e GFR in the normal or mildly impaired range and incident cadiovascular disease:Age and sex analysis[J].Eur J Intern Med,2018,54:70-75.
[9]MODIG S,ELMSTHL S.Kidney function and use of nonsteroidal anti-inflammatory drugs among elderly people:a cross-sectional study on potential hazards for an at risk population[J].Int J Clin pharm,2018,40(4):870-877.
[10]INAFUKU T,NOZAKI H.Liver function of the most elderly patients[J].Rinsho Byori,2000,48(3):227-232.
[11]BAERWALD C,VERDECCHIA P,DUQUESROIX B,et al.Efficacy,safety,and effects on blood pressure of naproxcinod750 mg twice daily compared with placebo and naproxen 500mg twice daily in patients with osteoarthritis of the hip:a randomized,double-blind,parallel-group,multicenter study[J].Arthritis Rheum,2010,62(12):3635-3644.
[12]HUANG K C,HUANG T W,YANG T Y,et al.Chronic NSAIDs Use Increases the Risk of a Second Hip Fracture in Patients After Hip Fracture Surgery:Evidence From a STROBE-Compliant Population-Based Study[J].Medicine(Baltimore),2015,94(38):e1566.
[13]AMINOSHARIAE A,KULILD J C,DONALDSON M.Shortterm use of nonsteroidal anti-inflammatory drugs and adverse effects:An updated systematic review[J].J Am Dent Assoc,2016,147(2):98-110.
[14]老年慢性非癌痛诊疗共识编写专家组.老年慢性非癌痛药物治疗中国专家共识[J].中国疼痛医学杂志,2016,22(5):321-325.
[15]中国医师协会疼痛科医师分会,国家临床重点专科·中日医院疼痛专科医联体,北京市疼痛治疗质量控制和改进中心.慢性肌肉骨骼疼痛的药物治疗专家共识(2018)[J].中国疼痛医学杂志,2018,24(12):881-887.
[16]PERGOLIZZI J V,RAFFA R B,MARCUM Z,et al.Safety of buprenorphine transdermal system in the management of pain in older adults[J].Postgrad Med,2017,129(1):92-101.
[17]QASEEM A,WILT T J,MCLEAN R M,et al.Noninvasive Treatments for Acute,Subacute,and Chronic Low Back Pain:A Clinical Practice Guideline From the American College of Physicians[J].Ann Intern Med,2017,166(7):514-530.
[18]SRIUTTHA P,SIRICHANCHUEN B,PERMSUWAN U.Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs:ASystematic Review of Randomized Controlled Trials[J].Int J Hepatol,2018,2018:5253623.
[19]JESSURUN N,VAN PUIJENBROEK E.Relationship between structural alerts in NSAIDs and idiosyncratic hepatotoxicity:an analysis of spontaneous report data from the WHO database[J].Drug Saf,2015,38(5):511-515.
[20]BESSONE F.Non-steroidal anti-inflammatory drugs:What is the actual risk of liver damage?[J].World J Gastroenterol,2010,16(45):5651-5661.
[21]WHELTON A.Nephrotoxicity of nonsteroidal anti-inflammatory drugs:physiologic foundations and clinical implications[J].Am J Med,1999,106(5B):13S-24S.
[22]ZHANG J,DING E L,SONG Y.Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events:metaanalysis of randomized trials[J].JAMA,2006,296(13):1619-1632.
[23]Coxib and Traditional NSAID Trialists’(CNT)Collaboration,BHALA N,EMBERSON J,et al.Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs:meta-analyses of individual participant data from randomised trials[J].Lancet,2013,382(9894):769-779.
[24]RUSCHITZKA F,BORER J S,KRUM H,et al.Differential blood pressure effects of ibuprofen,naproxen,and celecoxib in patients with arthritis:the PRECISION-ABPM(Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement)Trial[J].Eur Heart J,2017,38(44):3282-3292.
[25]DAVIS M P.Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain[J].JSupport Oncol,2012,10(6):209-219.
[26]COTTRELL J,O’CONNOR J P.Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing[J].Pharmaceuticals(Basel),2010,3(5):1668-1693.
[27]BORGEAT A,OFNER C,SAPORITO A,et al.The effect of nonsteroidal anti-inflammatory drugs on bone healing in humans:A qualitative,systematic review[J].J Clin Anesth,2018,49:92-100.
[28]KURMIS A P,KURMIS T P,O’BRIEN J X,et al.The effect of nonsteroidal anti-inflammatory drug administration on acute phase fracture-healing:a review[J].J Bone Joint Surg Am,2012,94(9):815-823.
[29]ALTMAN R D,LATTA L L,KEER R,et al.Effect of nonsteroidal antiinflammatory drugs on fracture healing:a laboratory study in rats[J].J Orthop Trauma,1995,9(5):392-400.