复发性流产病因学研究现状分析
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摘要
复发性流产为临床较为常见的妊娠并发症之一,属于妊娠早期衰退孕囊死亡的一种普遍形式,具有较高发生率,其不仅易影响女性心理健康与生活质量,还将对其妊娠结局产生直接影响,严重者可导致不孕不育,影响家庭和谐。随着生殖遗传学、生殖免疫学、分子细胞学技术的发展,临床对该疾病的发病机制有了新的发现,故本文将分析复发性流产的病因以及发病机制,拟为临床诊治提供理论依据,以改善妊娠结局,提高保胎成功率,降低RSA发生率。
Recurrent abortion is one of the more common pregnancy complications. It is a common form of gestational sac death in early pregnancy and has a high incidence. It is not only easy to affect women's mental health and quality of life, but also its pregnancy outcome. Direct impact, severe cases can lead to infertility, affecting family harmony. With the development of reproductive genetics, reproductive immunology, molecular cytology technology, the new pathogenesis of the disease has been discovered, so this article will analyze the etiology and pathogenesis of recurrent abortion,and provide a theoretical basis for clinical diagnosis and treatment. In order to improve the pregnancy outcome, improve the success rate of the fetus,and reduce the incidence of RSA.
Recurrent abortion is one of the more common pregnancy complications. It is a common form of gestational sac death in early pregnancy and has a high incidence. It is not only easy to affect women's mental health and quality of life, but also its pregnancy outcome. Direct impact, severe cases can lead to infertility, affecting family harmony. With the development of reproductive genetics, reproductive immunology, molecular cytology technology, the new pathogenesis of the disease has been discovered, so this article will analyze the etiology and pathogenesis of recurrent abortion,and provide a theoretical basis for clinical diagnosis and treatment. In order to improve the pregnancy outcome, improve the success rate of the fetus,and reduce the incidence of RSA.
引文
[1]张阳佳,朱宝生.复发性自然流产的病因学研究进展[J].中国妇幼保健,2015,30(10):1637-1640.
[2]Xu Z,Zhang Y,Liu W,et al.Polymorphisms of F2,PROC,PROZ,and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women[J].Clin Appl Thromb Hemost,2018,24(6):894-900.
[3]张宏展,余姝毅,陈现,等.复发性流产的病因分析[J].生殖医学杂志,2017,26(9):932-935.
[4]张影,徐祖滢,苏叶舟,等.1123对复发性流产夫妇的染色体核型分析[J].安徽医科大学学报,2018,53(5):759-763.
[5]杨学舟,权效珍,邢辉.复发性流产妇女内分泌影响因素分析[J].中国妇幼保健,2017,32(18):4330-4332.
[6]赵微.PCOS导致复发性流产的常见病因及治疗进展的探讨[J].中外医药研究,2018,1(30):118.
[7]贾新转,郭丽娜,张娜,等.原发不孕及复发性流产女性血清泌乳素与NK细胞相关性分析[J].现代预防医学,2017,44(16):2960-2962,2971.
[8]张帆,黄志琨,祝新武.联合检测激活素A、抑制素A及CA125在先兆流产预后评估及诊断中的价值[J].中国计划生育和妇产科,2016,8(3):49-51,61.
[9]史晓芸.慢性子宫内膜炎与复发性流产[J].国际生殖健康/计划生育杂志,2018,37(1):81-86.
[10]陈利形,尉江平.超声监测在子宫畸形合并早孕人工流产术中的临床价值[J].中国计划生育学杂志,2015,23(4):258-260.
[11]章艳,刘杨,饶慧,等.凝血因子Ⅻ基因C46T多态性与不明原因复发性流产及凝血因子Ⅻ活性的相关性[J].医学研究杂志,2018,47(5):169-173.
[12]Quan X,Yang X.Correlation between unexplained recurrent spontaneous abortion with CD4+CD25+regulatory T-cell and killer cell immunoglobulin-like receptor levels[J].Experimental&Therapeutic Medicine,2017,14(2):1459-1462.
[13]何全利,刘伟,杨思伟,等.不明原因复发性流产孕妇检测狼疮抗凝物质和同型半胱氨酸的意义[J].中国现代医学杂志,2018,28(27):94-97.
[14]邓天勤,邓敏芝,王毅,等.精子核成熟度与早期不明原因复发性流产的相关性研究[J].中国性科学,2017,26(5):116-118.
[15]付晓君,门波,孙自学,等.不明原因复发性流产与精子DNA完整性的相关性研究探讨[J].中国性科学,2018,27(3):132-134.
[16]金保方.复发性流产的男方因素与对策[J].中华男科学杂志,2017,23(1):867-872.
[17]王明远,常青,陈诚,等.环境内分泌干扰物对复发性流产影响的Meta分析[J].实用妇产科杂志,2016,32(11):864-868.
[18]郑灵芝,应翔,周荷玲,等.E-钙黏素在复发性流产孕妇妊娠早期滋养层细胞中的表达与HPV感染的相关性分析[J].中华医院感染学杂志,2017,27(20):4754-4757.
[19]乌守恒,林卫.复发性流产与生殖道感染[J].实用妇产科杂志,2016,32(2):85-86.
[20]龚桂芳,郑先琳,秦爽.复发性流产病人孕早期焦虑、抑郁情绪与血清β-HCG、孕酮的相关性[J].护理研究,2015,29(25):3162-3164.
[2]Xu Z,Zhang Y,Liu W,et al.Polymorphisms of F2,PROC,PROZ,and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women[J].Clin Appl Thromb Hemost,2018,24(6):894-900.
[3]张宏展,余姝毅,陈现,等.复发性流产的病因分析[J].生殖医学杂志,2017,26(9):932-935.
[4]张影,徐祖滢,苏叶舟,等.1123对复发性流产夫妇的染色体核型分析[J].安徽医科大学学报,2018,53(5):759-763.
[5]杨学舟,权效珍,邢辉.复发性流产妇女内分泌影响因素分析[J].中国妇幼保健,2017,32(18):4330-4332.
[6]赵微.PCOS导致复发性流产的常见病因及治疗进展的探讨[J].中外医药研究,2018,1(30):118.
[7]贾新转,郭丽娜,张娜,等.原发不孕及复发性流产女性血清泌乳素与NK细胞相关性分析[J].现代预防医学,2017,44(16):2960-2962,2971.
[8]张帆,黄志琨,祝新武.联合检测激活素A、抑制素A及CA125在先兆流产预后评估及诊断中的价值[J].中国计划生育和妇产科,2016,8(3):49-51,61.
[9]史晓芸.慢性子宫内膜炎与复发性流产[J].国际生殖健康/计划生育杂志,2018,37(1):81-86.
[10]陈利形,尉江平.超声监测在子宫畸形合并早孕人工流产术中的临床价值[J].中国计划生育学杂志,2015,23(4):258-260.
[11]章艳,刘杨,饶慧,等.凝血因子Ⅻ基因C46T多态性与不明原因复发性流产及凝血因子Ⅻ活性的相关性[J].医学研究杂志,2018,47(5):169-173.
[12]Quan X,Yang X.Correlation between unexplained recurrent spontaneous abortion with CD4+CD25+regulatory T-cell and killer cell immunoglobulin-like receptor levels[J].Experimental&Therapeutic Medicine,2017,14(2):1459-1462.
[13]何全利,刘伟,杨思伟,等.不明原因复发性流产孕妇检测狼疮抗凝物质和同型半胱氨酸的意义[J].中国现代医学杂志,2018,28(27):94-97.
[14]邓天勤,邓敏芝,王毅,等.精子核成熟度与早期不明原因复发性流产的相关性研究[J].中国性科学,2017,26(5):116-118.
[15]付晓君,门波,孙自学,等.不明原因复发性流产与精子DNA完整性的相关性研究探讨[J].中国性科学,2018,27(3):132-134.
[16]金保方.复发性流产的男方因素与对策[J].中华男科学杂志,2017,23(1):867-872.
[17]王明远,常青,陈诚,等.环境内分泌干扰物对复发性流产影响的Meta分析[J].实用妇产科杂志,2016,32(11):864-868.
[18]郑灵芝,应翔,周荷玲,等.E-钙黏素在复发性流产孕妇妊娠早期滋养层细胞中的表达与HPV感染的相关性分析[J].中华医院感染学杂志,2017,27(20):4754-4757.
[19]乌守恒,林卫.复发性流产与生殖道感染[J].实用妇产科杂志,2016,32(2):85-86.
[20]龚桂芳,郑先琳,秦爽.复发性流产病人孕早期焦虑、抑郁情绪与血清β-HCG、孕酮的相关性[J].护理研究,2015,29(25):3162-3164.