红曲蜂胶片辅助降血脂功能的研究
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摘要
研究红曲蜂胶片对高脂血症模型大鼠血脂及脂蛋白的影响。将50只SD大鼠随机分为5组,分别为空白对照组、高脂血症模型组和红曲蜂胶片低、中、高剂量组(0.17、0.33、1.00 g/kg,分别相当于人推荐摄入量的5、10、30倍),每组10只。各组每日灌胃相应的受试物或溶剂,连续灌胃6周。模型组大鼠总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)含量均显著升高(P<0.01)。与模型组比较,中剂量组大鼠血清LDL-C含量,中、高剂量组大鼠血清TG含量均明显降低(P<0.05),差异均有统计学意义。证明红曲蜂胶片具有辅助降血脂功能。
The hypolipidemic effect of monascus and propolis tablet(MPT)on experimental rats was studied. 50 SD rats were randomly divided into 5 groups:control group,hyperlipidemia model group and low,middle and high dose of monascus and propolis tablet groups(0.17,0.33,1.00 g/kg equivalent to 5,10 and 30 times of the recommended dose of human respectively),each with 10. All the groups were administered with their own test substance by gavage for 6 weeks. Compared with the control group,serm total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in model group were increased significantly(P<0.01).Compared with the model group,LDL-C level in the serum of rats in middle dose group and TG level in the serum of rats in middle and high dose groups were obviously decreased(P <0.05),the differences were statistically significant. The Monascus and propolis Tablet could decrease the serum lipid level effectively.
The hypolipidemic effect of monascus and propolis tablet(MPT)on experimental rats was studied. 50 SD rats were randomly divided into 5 groups:control group,hyperlipidemia model group and low,middle and high dose of monascus and propolis tablet groups(0.17,0.33,1.00 g/kg equivalent to 5,10 and 30 times of the recommended dose of human respectively),each with 10. All the groups were administered with their own test substance by gavage for 6 weeks. Compared with the control group,serm total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in model group were increased significantly(P<0.01).Compared with the model group,LDL-C level in the serum of rats in middle dose group and TG level in the serum of rats in middle and high dose groups were obviously decreased(P <0.05),the differences were statistically significant. The Monascus and propolis Tablet could decrease the serum lipid level effectively.
引文
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[2]Moran A,Gu D,Zhao D,et al.Future cardiovascular disease in china:markov model and risk factor scenario projections from the coronary heart disease policy model-china[J].Circulation Cardiovascular Quality&Outcomes,2010,3(3):243-252
[3]王亭.成人血脂异常的流行特征与影响因素[J].职业与健康,2015,31(7):1000-1005
[4]Pan L,Yang Z,Wu Y,et al.The prevalence,awareness,treatment and control of dyslipidemia among adults in China[J].Atherosclerosis,2016,248:2-9
[5]丁文清,董虹孛,米杰.中国儿童青少年血脂异常流行现状Meta分析[J].中华流行病学杂志,2015,36(1):71-77
[6]钱荣华,赵斐,竹剑平.蜂胶降血脂作用的实验研究[J].心脑血管病防治,2003,3(4):24-25
[7]王玲,吴军林,吴清平.红曲降血脂功能的研究及应用概况[J].食品工业科技,2014,35(8):387-389,393
[8]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,16(10):15-35
[9]李雪梅,沈兴海,段震文,等.红曲的药理活性研究进展[J].Chinese Journal of Natural Medicines,2011(3):161-166
[10]高跃中,于堔,严根祥,等.功能性红曲治疗高脂血症的疗效观察[J].医药前沿,2016,6(18):359-360
[11]ENDO AKIRA,Monacolin K.A New Hypocholesterolemic Agent Produced by a Monascus Species[J].Journal of Antibiotics,1979,32(8):852-854
[12]殷梦梅,叶晖,张学智.红曲单药及复方制剂治疗高脂血症的研究进展[J].医学综述,2017,23(2):344-347
[13]戴伟,周景洋,陈学智,等.红曲胶囊调节血脂作用的人体试食研究[J].预防医学论坛,2003,9(5):563-564
[14]Chen C H,Yang J C,Uang Y S,et al.Improved dissolution rate and oral bioavailability of lovastatin in red yeast rice products[J].International Journal of Pharmaceutics,2013,444(1/2):18-24
[15]高雅娟.红曲中非他汀物质降血脂机理的初步研究[D].天津:天津科技大学,2016
[16]刘青云,徐先祥.蜂胶的药理作用研究进展[J].安徽医药,2007,11(1):1-3
[17]杨庆,张鹏,刘建中.蜂胶软胶囊毒性和对大鼠血脂调节作用[J].中国卫生检验杂志,2007,17(6):1103-1108
[18]王雪梅,王飞飞,田海霞,等.巴西蜂胶和国产蜂胶乙醇浓缩液对2型糖尿病大鼠糖、脂代谢的影响研究[J].糖尿病新世界,2015(17):56-59
[19]刘臻,王茵.蜂胶降血脂功能的研究进展[J].健康天地:学术版,2009,3(12):33-35
[20]李勇.他汀类药物与动脉粥样硬化性心血管疾病一级预防:我们所处何处?该有何为?[J].中华内科杂志,2016,38(4):521-524