急性胰腺炎的凝血紊乱研究进展
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摘要
急性胰腺炎发展到凝血功能紊乱是病情严重的重要标志,同时可能导致多种血管并发症如早期的局部胰腺灌注受损和晚期的门静脉系统血栓,从而很大程度影响疾病的治疗和预后。文章主要就凝血紊乱的胰腺微循环基础、血管和凝血系统的变化、门静脉血栓形成及凝血紊乱的防治等方面进行综述。
The progression of acute pancreatitis to coagulation dysfunction is an important indicator of the severity of the dis?ease. Meanwhile,it may lead to a variety of vascular complications,such as primary local pancreatic perfusion injury and late portal venous thrombosis which greatly affect the treatment and prognosis of the disease. This article mainly reviews the basis of pancreatic microcirculation,changes of blood vessels and coagulation system,portal vein thrombosis and the prevention and treatment of coagula?tion disorders.
The progression of acute pancreatitis to coagulation dysfunction is an important indicator of the severity of the dis?ease. Meanwhile,it may lead to a variety of vascular complications,such as primary local pancreatic perfusion injury and late portal venous thrombosis which greatly affect the treatment and prognosis of the disease. This article mainly reviews the basis of pancreatic microcirculation,changes of blood vessels and coagulation system,portal vein thrombosis and the prevention and treatment of coagula?tion disorders.
引文
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[6]李百强,杨娜,叶博,等.重症急性胰腺炎并发持续性炎症反应-免疫抑制-分解代谢综合征临床分析[J].医学研究生学报,2017,30(7):719-724.
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[14]Zhou J,Ke L,Tong Z,et al. Risk factors and outcome of splanchnic venous thrombosis in patients with necrotizing acute pancreatitis[J]. Thromb Res,2015,135(1):68-72.
[15]黄泽平,郭亚民,吴新民,等.重症急性胰腺炎与凝血功能紊乱[J].中华胰腺病杂志,2010,10(6):455-458.
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[17]Ping C,Yongping Z,Minmin Q,et al. Activated protein C im?proves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and throm?bomodulin[J]. Dig Dis Sci,2010,55(6):1599-1609.
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[19]Hack CE. Tissue factor pathway of coagulation in sepsis[J]. Crit Care Med,2000,28(9 Suppl):25-30.
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[21]Radenkovic D,Bajec D,Ivancevic N,et al. D-dimer in acute pancreatitis:a new approach for an early assessment of organ failure[J]. Pancreas,2009,38(6):655-660.
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[24]Harris S,Nadkarni NA,Naina HV,et al. Splanchnic vein thrombosis in acute pancreatitis:a single-center experience[J].Pancreas,2013,42(8):1251-1254.
[25]Easler J,Muddana V,Furlan A,et al. Portosplenomesenteric venous thrombosis in patients with acute pancreatitis is associat?ed with pancreatic necrosis and usually has a benign course[J].Clin Gastroenterol Hepatol,2014,12(5):854-862.
[26]Dorffel T,Wruck T,Ruckert RI,et al. Vascular complications in acute pancreatitis assessed by color duplex ultrasonography[J]. Pancreas,2000,21(2):126-133.
[27]李爽,张桂信,尚东.急性胰腺炎并发门静脉系统血栓形成的研究进展[J].世界华人消化杂志,2015,28:4529-4535.
[28]Zhou J,Chen Y,Li G,et al. Predicting the clinical manifesta?tions in necrotizing acute pancreatitis patients with splanchnic vein thrombosis[J]. Pancreatology,2016,16(6):973-978.
[29]Jiang W,Zhou J,Ke L,et al. Splanchnic vein thrombosis in necrotizing acute pancreatitis:Detection by computed tomo?graphic venography[J]. World J Gastroenterol,2014,20(44):16698-16701.
[30]Zhou J,Ke L,Tong Z,et al. Risk factors and outcome of splanchnic venous thrombosis in patients with necrotizing acute pancreatitis[J]. Thromb Res,2015,135(1):68-72.
[31]Gonzelez HJ,Sahay SJ,Samadi B,et al. Splanchnic vein thrombosis in severe acute pancreatitis:a 2-year,single-institu?tion experience[J]. HPB(Oxford),2011,13(12):860-864.
[32]Dorffel T,Wruck T,Ruckert RI,et al. Vascular complications in acute pancreatitis assessed by color duplex ultrasonography[J]. Pancreas,2000,21(2):126-133.
[33]Tomkotter L,Erbes J,Trepte C,et al. The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Dam?age and the Outcome in Severe Acute Pancreatitis[J]. Pancreas,2016,45(2):248-253.
[34]Mikami Y,Takeda K,Matsuda K. et al. Rat experimental mod?el of continuous regional arterial infusion of protease inhibitor and its effects on severe acute pancreatitis[J]. Pancreas,2005,30(3):248-253.
[35]Lu G,Tong Z,Ding Y,et al. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice[J]. Biomed Res Int,2016,2016:6089430.
[36]Hall T C,Garcea G,Metcalfe M,et al. Management of acute non-cirrhotic and non-malignant portal vein thrombosis:a sys?tematic review[J]. World J Surg,2011,35(11):2510-2520.
[2]Baron TH,Morgan DE. Acute necrotizing pancreatitis[J]. N Engl J Med,1999,340(18):1412-1417.
[3]Beger HG,Rau B,Isenmann R. Natural history of necrotizing pancreatitis[J]. Pancreatology,2003,3(2):93-101.
[4]Garg PK,Madan K,Pande GK,et al. Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis[J]. Clin Gastroenterol Hepatol,2005,3(2):159-166.
[5]Guo Q,Li A,Xia Q,et al. The role of organ failure and infec?tion in necrotizing pancreatitis:a prospective study[J]. Ann Surg,2014,259(6):1201-1207.
[6]李百强,杨娜,叶博,等.重症急性胰腺炎并发持续性炎症反应-免疫抑制-分解代谢综合征临床分析[J].医学研究生学报,2017,30(7):719-724.
[7]Mitchell RM,Byrne MF,Baillie J. Pancreatitis[J]. Lancet,2003,361(9367):1447-1455.
[8]Slavin J,Ghaneh P,Sutton R,et al. Management of necrotizing pancreatitis[J]. World J Gastroenterol,2001,7(4):476-481.
[9]Cuthbertson CM,Christophi C. Disturbances of the microcircu?lation in acute pancreatitis[J]. Br J Surg,2006,93(5):518-530.
[10]Ranson JH,Lackner H,Berman IR,et al. The relationship of coagulation factors to clinical complications of acute pancreatitis[J]. Surgery,1977,81(5):502-511.
[11]Ge N,Xia Q,Yang ZH,et al. Vascular endothelial injury and apoptosis in rats with severe acute pancreatitis[J]. Gastroenterol Res Pract,2015,2015:235017.
[12]赵春菱,赵晓琴.重症急性胰腺炎死亡相关因素分析及对策[J].蛇志,2012,4:363-365.
[13]江为.重症急性胰腺炎并发门静脉系统血栓临床研究[D].南京大学,2015:1-100.
[14]Zhou J,Ke L,Tong Z,et al. Risk factors and outcome of splanchnic venous thrombosis in patients with necrotizing acute pancreatitis[J]. Thromb Res,2015,135(1):68-72.
[15]黄泽平,郭亚民,吴新民,等.重症急性胰腺炎与凝血功能紊乱[J].中华胰腺病杂志,2010,10(6):455-458.
[16]Chen Y,Ke L,Meng L,et al. Endothelial markers are associat?ed with pancreatic necrosis and overall prognosis in acute pan?creatitis:A preliminary cohort study[J]. Pancreatology,2017,17(1):45-50.
[17]Ping C,Yongping Z,Minmin Q,et al. Activated protein C im?proves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and throm?bomodulin[J]. Dig Dis Sci,2010,55(6):1599-1609.
[18]Matsumoto T,Wada H,Nobori T,et al. Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation[J]. Clin Appl Thromb Hemost,2005,11(4):391-400.
[19]Hack CE. Tissue factor pathway of coagulation in sepsis[J]. Crit Care Med,2000,28(9 Suppl):25-30.
[20]Sawa H,Ueda T,Takeyama Y,et al. Elevation of plasma tissue factor levels in patients with severe acute pancreatitis[J]. J Gas?troenterol,2006,41(6):575-581.
[21]Radenkovic D,Bajec D,Ivancevic N,et al. D-dimer in acute pancreatitis:a new approach for an early assessment of organ failure[J]. Pancreas,2009,38(6):655-660.
[22]Wang Z,Ye J,Han YH. Acute pancreatitis associated with her?pes zoster:case report and literature review[J]. World J Gastro?enterol,2014,20(47):18053-18056.
[23]Ke L,Tong ZH,Li WQ,et al. Predictors of critical acute pan?creatitis:a prospective cohort study[J]. Medicine(Baltimore),2014,93(21):e108.
[24]Harris S,Nadkarni NA,Naina HV,et al. Splanchnic vein thrombosis in acute pancreatitis:a single-center experience[J].Pancreas,2013,42(8):1251-1254.
[25]Easler J,Muddana V,Furlan A,et al. Portosplenomesenteric venous thrombosis in patients with acute pancreatitis is associat?ed with pancreatic necrosis and usually has a benign course[J].Clin Gastroenterol Hepatol,2014,12(5):854-862.
[26]Dorffel T,Wruck T,Ruckert RI,et al. Vascular complications in acute pancreatitis assessed by color duplex ultrasonography[J]. Pancreas,2000,21(2):126-133.
[27]李爽,张桂信,尚东.急性胰腺炎并发门静脉系统血栓形成的研究进展[J].世界华人消化杂志,2015,28:4529-4535.
[28]Zhou J,Chen Y,Li G,et al. Predicting the clinical manifesta?tions in necrotizing acute pancreatitis patients with splanchnic vein thrombosis[J]. Pancreatology,2016,16(6):973-978.
[29]Jiang W,Zhou J,Ke L,et al. Splanchnic vein thrombosis in necrotizing acute pancreatitis:Detection by computed tomo?graphic venography[J]. World J Gastroenterol,2014,20(44):16698-16701.
[30]Zhou J,Ke L,Tong Z,et al. Risk factors and outcome of splanchnic venous thrombosis in patients with necrotizing acute pancreatitis[J]. Thromb Res,2015,135(1):68-72.
[31]Gonzelez HJ,Sahay SJ,Samadi B,et al. Splanchnic vein thrombosis in severe acute pancreatitis:a 2-year,single-institu?tion experience[J]. HPB(Oxford),2011,13(12):860-864.
[32]Dorffel T,Wruck T,Ruckert RI,et al. Vascular complications in acute pancreatitis assessed by color duplex ultrasonography[J]. Pancreas,2000,21(2):126-133.
[33]Tomkotter L,Erbes J,Trepte C,et al. The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Dam?age and the Outcome in Severe Acute Pancreatitis[J]. Pancreas,2016,45(2):248-253.
[34]Mikami Y,Takeda K,Matsuda K. et al. Rat experimental mod?el of continuous regional arterial infusion of protease inhibitor and its effects on severe acute pancreatitis[J]. Pancreas,2005,30(3):248-253.
[35]Lu G,Tong Z,Ding Y,et al. Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice[J]. Biomed Res Int,2016,2016:6089430.
[36]Hall T C,Garcea G,Metcalfe M,et al. Management of acute non-cirrhotic and non-malignant portal vein thrombosis:a sys?tematic review[J]. World J Surg,2011,35(11):2510-2520.