阿司匹林联合小剂量氯吡格雷对高龄脑梗死患者神经功能的影响
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摘要
目的探讨阿司匹林联合小剂量氯吡格雷对高龄脑梗死患者神经功能的影响。方法选取高龄脑梗死患者120例,根据治疗方案分为2组各60例。对照组采用阿司匹林(100 mg)治疗,观察组采用阿司匹林(50 mg)+小剂量氯吡格雷(25 mg)治疗。治疗14 d后,比较2组治疗前后的神经功能、日常生活能力、疗效和不良反应发生情况。结果治疗后,观察组患者的脑卒中量表(NIHSS)评分显著低于对照组,Barthel评定量表(BI)评分显著高于对照组(P <0. 05)。观察组总有效率91. 67%,显著高于对照组的73. 33%(P <0. 05)。2组不良反应发生率比较无显著差异(P> 0. 05)。结论阿司匹林联合小剂量氯吡格雷治疗高龄脑梗死患者疗效显著,可有效促进患者神经功能恢复,提高日常生活能力。
Objective To investigate the effect of aspirin combined with small dose clopidogrel on neurological function in elderly patients with cerebral infarction. Methods Totally 120 elderly patients with cerebral infarction were selected and divided into two groups according to therapeutic regimens. The control group was treated with aspirin( 100 mg),while the observation group was treated with aspirin( 50 mg) plus small dose clopidogrel( 25 mg). After 14 days of treatment,the neurological function,daily living ability,efficacy and incidence of adverse reactions before and after treatment were compared between two groups. Results After treatment,the stroke scale( NIHSS) score of the observation group was significantly lower than that of the control group,and the score of Barthel rating scale( BI) was significantly higher than that of the control group( P < 0. 05). The total effective rate of the observation group was 91. 67%,which was significantly higher than 73. 33%of the control group( P < 0. 05). There was no significant difference in the incidence rate of adverse reactions between the two groups( P > 0. 05). Conclusion Aspirin combined with small dose clopidogrel is effective in the treatment of elderly patients with cerebral infarction,which can effectively promote the recovery of neurological function and improve daily living ability.
Objective To investigate the effect of aspirin combined with small dose clopidogrel on neurological function in elderly patients with cerebral infarction. Methods Totally 120 elderly patients with cerebral infarction were selected and divided into two groups according to therapeutic regimens. The control group was treated with aspirin( 100 mg),while the observation group was treated with aspirin( 50 mg) plus small dose clopidogrel( 25 mg). After 14 days of treatment,the neurological function,daily living ability,efficacy and incidence of adverse reactions before and after treatment were compared between two groups. Results After treatment,the stroke scale( NIHSS) score of the observation group was significantly lower than that of the control group,and the score of Barthel rating scale( BI) was significantly higher than that of the control group( P < 0. 05). The total effective rate of the observation group was 91. 67%,which was significantly higher than 73. 33%of the control group( P < 0. 05). There was no significant difference in the incidence rate of adverse reactions between the two groups( P > 0. 05). Conclusion Aspirin combined with small dose clopidogrel is effective in the treatment of elderly patients with cerebral infarction,which can effectively promote the recovery of neurological function and improve daily living ability.
引文
[1]郭爱红,王丙聚,韩晓芳.阿司匹林联合氯吡格雷治疗急性脑梗死并脑微出血的临床疗效[J].实用心脑肺血管病杂志,2017,25(5):109-111.
[2]亓慧敏.氯吡格雷联合阿司匹林治疗对急性脑梗死患者血小板活化聚集状态的研究[J].河北医学,2017,23(3):374-377.
[3]李兰红,王晋芳.阿司匹林联合氯吡格雷治疗急性进展性脑梗死的疗效观察[J].中西医结合心脑血管病杂志,2016,14(16):1926-1927.
[4]郭爱红,王丙聚,韩晓芳.阿司匹林联合氯吡格雷治疗急性脑梗死并脑微出血的临床疗效[J].实用心脑肺血管病杂志,2017,25(5):109-111.
[5]聂莉,乔向亮,胡苏华,等.氯吡格雷联合阿司匹林对脑梗死患者血清细胞炎症因子和Hcy水平的影响[J].中国实用神经疾病杂志,2017,20(4):52-54.
[6]王新德.各类脑血管疾病诊断要点[J].中华神经科杂志,1996(6):379-380.
[7]侯东哲,张颖,巫嘉陵.中文版美国国立卫生院脑卒中量表的信度与效度研究[J].中华物理医学与康复杂志,2012,34(5):372-374.
[8]闵瑜,吴媛媛,燕铁斌.改良Barthel指数(简体中文版)量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志,2008,30(3):185-188.
[9]任伟成.分期整体针灸法与常规针灸法治疗脑梗死的临床疗效观察[J].四川中医,2018,36(1):184-187.
[10]黄琼霞,林涛,晏昆,等.小剂量阿司匹林联合氯吡格雷治疗急性缺血性脑血管病的效果观察[J].白求恩医学杂志,2018,16(1):50-51.
[11]阿司匹林联合氯吡格雷对脑梗死患者同型半胱氨酸、超敏C反应蛋白的影响及预后分析[J].实用临床医药杂志,2017,21(19):38-40,43.
[12]孟庆玲.阿司匹林联合氯吡格雷对急性缺血性脑血管病患者神经功能及日常生活能力的影响[J].中国医药导报,2017,14(22):69-71,128.
[13]张明池.阿司匹林联合氯吡格雷对急性进展性脑梗死患者神经功能的影响[J].西藏医药,2017,38(2):51-53.
[14]张玉侠.阿司匹林与氯吡格雷联合给药对急性脑梗死患者神经功能、生活质量的影响分析[J].河南医学研究,2017,26(5):849-850.
[15]赵东肖.丁苯酞联合阿司匹林和氯吡格雷治疗高龄脑梗死患者的临床安全性及疗效研究[J].中国民康医学,2017,29(1):23-24.
[16]吴丽娟,虞炳庆.阿司匹林联合氯吡格雷对急性缺血性脑卒中神经功能及血清CRP与血脂的影响[J].临床医学,2017,37(6):11-14.
[17]王坤,段毅,王军英,等.阿司匹林联合氯吡格雷治疗对缺血性脑卒中病人神经功能及血小板聚集率的影响[J].中西医结合心脑血管病杂志,2017,15(17):2207-2209.
[18]彭敏.小剂量氯吡格雷联合阿司匹林用于75岁以上急性脑梗死患者的疗效及安全性评价[J].中国药业,2016,25(11):55-57.
[2]亓慧敏.氯吡格雷联合阿司匹林治疗对急性脑梗死患者血小板活化聚集状态的研究[J].河北医学,2017,23(3):374-377.
[3]李兰红,王晋芳.阿司匹林联合氯吡格雷治疗急性进展性脑梗死的疗效观察[J].中西医结合心脑血管病杂志,2016,14(16):1926-1927.
[4]郭爱红,王丙聚,韩晓芳.阿司匹林联合氯吡格雷治疗急性脑梗死并脑微出血的临床疗效[J].实用心脑肺血管病杂志,2017,25(5):109-111.
[5]聂莉,乔向亮,胡苏华,等.氯吡格雷联合阿司匹林对脑梗死患者血清细胞炎症因子和Hcy水平的影响[J].中国实用神经疾病杂志,2017,20(4):52-54.
[6]王新德.各类脑血管疾病诊断要点[J].中华神经科杂志,1996(6):379-380.
[7]侯东哲,张颖,巫嘉陵.中文版美国国立卫生院脑卒中量表的信度与效度研究[J].中华物理医学与康复杂志,2012,34(5):372-374.
[8]闵瑜,吴媛媛,燕铁斌.改良Barthel指数(简体中文版)量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志,2008,30(3):185-188.
[9]任伟成.分期整体针灸法与常规针灸法治疗脑梗死的临床疗效观察[J].四川中医,2018,36(1):184-187.
[10]黄琼霞,林涛,晏昆,等.小剂量阿司匹林联合氯吡格雷治疗急性缺血性脑血管病的效果观察[J].白求恩医学杂志,2018,16(1):50-51.
[11]阿司匹林联合氯吡格雷对脑梗死患者同型半胱氨酸、超敏C反应蛋白的影响及预后分析[J].实用临床医药杂志,2017,21(19):38-40,43.
[12]孟庆玲.阿司匹林联合氯吡格雷对急性缺血性脑血管病患者神经功能及日常生活能力的影响[J].中国医药导报,2017,14(22):69-71,128.
[13]张明池.阿司匹林联合氯吡格雷对急性进展性脑梗死患者神经功能的影响[J].西藏医药,2017,38(2):51-53.
[14]张玉侠.阿司匹林与氯吡格雷联合给药对急性脑梗死患者神经功能、生活质量的影响分析[J].河南医学研究,2017,26(5):849-850.
[15]赵东肖.丁苯酞联合阿司匹林和氯吡格雷治疗高龄脑梗死患者的临床安全性及疗效研究[J].中国民康医学,2017,29(1):23-24.
[16]吴丽娟,虞炳庆.阿司匹林联合氯吡格雷对急性缺血性脑卒中神经功能及血清CRP与血脂的影响[J].临床医学,2017,37(6):11-14.
[17]王坤,段毅,王军英,等.阿司匹林联合氯吡格雷治疗对缺血性脑卒中病人神经功能及血小板聚集率的影响[J].中西医结合心脑血管病杂志,2017,15(17):2207-2209.
[18]彭敏.小剂量氯吡格雷联合阿司匹林用于75岁以上急性脑梗死患者的疗效及安全性评价[J].中国药业,2016,25(11):55-57.