温度对聚(N-异丙基丙烯酰胺)水凝胶内部结构及性能影响的研究
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摘要
分别在0℃、25℃、60℃的水溶液中通过自由基交联聚合,制备了聚(N-异丙基丙烯酰胺)水凝胶。研究了温度对于水凝胶内部微观结构的影响并分析了内部微观结构与水凝胶性能之间的关系。用扫描电镜(SEM)、红外光谱仪(FT-IR)和差示扫描量热仪(DSC)对制备的凝胶进行表征。结果表明,3种水凝胶具有相同的化学组成和相转变温度,但其内部微观结构有较大差别。通过测试水凝胶的温敏性、溶胀动力学和脉冲响应性发现:改变温度可以有效地改变水凝胶的内部结构,在较高温度下制得的水凝胶具有较高的溶胀率、较快的去溶胀速率和较强的脉冲响应性。
Poly( N-isopropylacrylamide)( PNIPAAm) are fabricated by free radical polymerization in aqueous solution at three different temperature,0 ℃,25 ℃ and 60 ℃. The effect of fabrication temperature on their internal microstructures were studied. The relationships between the internal microstructures of PNIPAAm and their properties were also analyzed. The PNIPAAm hydrogels was characterized by scanning electron microscopy( SEM),differential scanning calorimetry( DSC) and Fourier trans-form infrared spectroscopy( FT-IR). The results show that the chemical compositions and the phase transition temperature of different hydrogels are similar,but their microstructures are different. By testing the temperature sensitivity,swelling kinetics and impulse response of the hydrogel,it was found that the internal structure of the hydrogel can be changed by changing the fabrication temperature and the hydrogels which were prepared at higher temperature had a higher swelling ratio,a faster rate of swelling and a stronger impulse response.
Poly( N-isopropylacrylamide)( PNIPAAm) are fabricated by free radical polymerization in aqueous solution at three different temperature,0 ℃,25 ℃ and 60 ℃. The effect of fabrication temperature on their internal microstructures were studied. The relationships between the internal microstructures of PNIPAAm and their properties were also analyzed. The PNIPAAm hydrogels was characterized by scanning electron microscopy( SEM),differential scanning calorimetry( DSC) and Fourier trans-form infrared spectroscopy( FT-IR). The results show that the chemical compositions and the phase transition temperature of different hydrogels are similar,but their microstructures are different. By testing the temperature sensitivity,swelling kinetics and impulse response of the hydrogel,it was found that the internal structure of the hydrogel can be changed by changing the fabrication temperature and the hydrogels which were prepared at higher temperature had a higher swelling ratio,a faster rate of swelling and a stronger impulse response.
引文
[1]周晓咪,孙晓然. p H、温度敏感型智能水凝胶的研究进展[J].化学世界,2013,54(12):747-750.
[2]李智慧,刘文涛,李中原,等. PNIPA/PEG多孔水凝胶的溶胀与药物释放性能[J].辐射研究与辐射工艺学报,2013,31(2):1-8.
[3] SUZUKI A,TANAKA T. Phase transition in polymer gels induced by visible light[J]. Nature,1990,346:345-347.
[4] TAE G K B. Temperature modulated protein release form p H/temperature sensitive hydorgels[J]. Biomaterials,1999,20:517-521.
[5] CASTRO L V,RAGHAVAN S L,SNOWDEN M J. Colloidal microgels as transdermal delivery systems[J]. Reactive and Functional Polymers,2004,58(3):175-185.
[6] PARK T G,HOFFMAN A S. Immobilization of arthrobacter simplex cells in thermally reversible hydrogel:effect of gel hydrophobicity on steroid conversion[J]. Biotechnol Prog,1991,7:383-390.
[7] ZHANG J,PEPPAS N A. Synthesis and characterization of pH-and temperature-sensitive poly(methacrylicacid)/poly(N-isopropylacrylamide)interpenetrating polymeric networks[J]. Macromolecules,2000,33:102-106.
[8]刘晓华,王晓工,刘德山.快速响应的温敏性聚(N-异丙基丙烯酰胺)水凝胶[J].高分子学报,2002(3):354-357.
[9]秦爱香,吕满庚,刘群峰,等.快速响应的温敏性聚(N-异丙基丙烯酰胺)水凝胶的合成及表征[J].应用化学,2006,23(6):581-585.
[10]陈兆伟,陈明清,刘晓亚,等.温敏性聚(N-异丙基丙烯酰胺)水凝胶的合成与表征[J].功能高分子学报,2004,17(1):46-50.
[11]刘文涛,张鸿儒,李智慧,等.多孔聚N-异丙基丙烯酰胺水凝胶的制备与缓释性能[J].高分子通报,2010(12):67-71.
[12]杨漪,邓军,程方明,等.快速响应型P(NIPA-co-SA)水凝胶制备及温敏性能[J].功能材料,2014,45(增刊2):129-135.
[13]张先正,卓仁禧.快速温度敏感聚(N-异丙基丙烯酰胺-co-丙烯酰胺)水凝胶的制备及性能研究[J].高等学校化学学报,2000,8(27):1309-1311.
[2]李智慧,刘文涛,李中原,等. PNIPA/PEG多孔水凝胶的溶胀与药物释放性能[J].辐射研究与辐射工艺学报,2013,31(2):1-8.
[3] SUZUKI A,TANAKA T. Phase transition in polymer gels induced by visible light[J]. Nature,1990,346:345-347.
[4] TAE G K B. Temperature modulated protein release form p H/temperature sensitive hydorgels[J]. Biomaterials,1999,20:517-521.
[5] CASTRO L V,RAGHAVAN S L,SNOWDEN M J. Colloidal microgels as transdermal delivery systems[J]. Reactive and Functional Polymers,2004,58(3):175-185.
[6] PARK T G,HOFFMAN A S. Immobilization of arthrobacter simplex cells in thermally reversible hydrogel:effect of gel hydrophobicity on steroid conversion[J]. Biotechnol Prog,1991,7:383-390.
[7] ZHANG J,PEPPAS N A. Synthesis and characterization of pH-and temperature-sensitive poly(methacrylicacid)/poly(N-isopropylacrylamide)interpenetrating polymeric networks[J]. Macromolecules,2000,33:102-106.
[8]刘晓华,王晓工,刘德山.快速响应的温敏性聚(N-异丙基丙烯酰胺)水凝胶[J].高分子学报,2002(3):354-357.
[9]秦爱香,吕满庚,刘群峰,等.快速响应的温敏性聚(N-异丙基丙烯酰胺)水凝胶的合成及表征[J].应用化学,2006,23(6):581-585.
[10]陈兆伟,陈明清,刘晓亚,等.温敏性聚(N-异丙基丙烯酰胺)水凝胶的合成与表征[J].功能高分子学报,2004,17(1):46-50.
[11]刘文涛,张鸿儒,李智慧,等.多孔聚N-异丙基丙烯酰胺水凝胶的制备与缓释性能[J].高分子通报,2010(12):67-71.
[12]杨漪,邓军,程方明,等.快速响应型P(NIPA-co-SA)水凝胶制备及温敏性能[J].功能材料,2014,45(增刊2):129-135.
[13]张先正,卓仁禧.快速温度敏感聚(N-异丙基丙烯酰胺-co-丙烯酰胺)水凝胶的制备及性能研究[J].高等学校化学学报,2000,8(27):1309-1311.