左乙拉西坦治疗癫痫的临床疗效及其安全性
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摘要
目的探讨左乙拉西坦治疗癫痫的临床疗效及其安全性。方法选取永州市中心医院2017年2月—2018年1月收治的癫痫患者60例,随机分为对照组与观察组,各30例。对照组予以奥卡西平治疗,观察组予以左乙拉西坦治疗,连续治疗6个月。比较两组患者临床疗效,并观察两组患者不良反应发生情况。结果观察组患者总有效率高于对照组,不良反应发生率低于对照组(P<0.05)。结论左乙拉西坦治疗癫痫的临床疗效确切,且安全性高。
Objective To evaluate clinical effect and the safety of levoethracetam in the treatment of epilepsy.Methods A total of 100 cases of patients with epilepsy were selected from February 2017 to January 2018 in Yongzhou Central Hospital,which were randomly divided into control and observation group,30 cases in each group.The control group was treated with oxcarbazepine,the observation group was treated with levetiracetam.Both groups were treated for 6 months.The clinical effect were compared between the two groups,and the incidence of adverse reactions were observed.Results The observation group of total effective rate was higher than control group,the incidence rate of adverse reaction was lower than control group(P<0.05).Conclusion Levoethracetam have an exact clinical effect for epilepsy,and with high safety.
Objective To evaluate clinical effect and the safety of levoethracetam in the treatment of epilepsy.Methods A total of 100 cases of patients with epilepsy were selected from February 2017 to January 2018 in Yongzhou Central Hospital,which were randomly divided into control and observation group,30 cases in each group.The control group was treated with oxcarbazepine,the observation group was treated with levetiracetam.Both groups were treated for 6 months.The clinical effect were compared between the two groups,and the incidence of adverse reactions were observed.Results The observation group of total effective rate was higher than control group,the incidence rate of adverse reaction was lower than control group(P<0.05).Conclusion Levoethracetam have an exact clinical effect for epilepsy,and with high safety.
引文
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[2]王俊,张华年,陈渝军,等.儿童体内左乙拉西坦血药浓度与单药治疗临床疗效的关系[J].中国医院药学杂志,2016,36(6):476-480.
[3]张守利,莫亚玲,赵德运,等.左乙拉西坦单药治疗癫痫患儿临床效果及其对骨代谢的影响[J].河北医科大学学报,2015,36(9):1076-1079.
[4]屈会霞.托吡酯和左乙拉西坦单药治疗癫痫患儿的疗效及不良反应对比[J].中国实用神经疾病杂志,2017,20(11):84-86.
[5]龚娟.左乙拉西坦单药治疗儿童癫痫临床疗效观察及对认知功能的影响[J].当代医学,2016,22(12):124-125.
[6]黄琳,赵京玉,文睿婷,等.左乙拉西坦治疗妊娠期癫痫疗效及胎儿安全性的Meta分析[J].中国医院药学杂志,2017,37(1):43-47.
[7]王红梅,王晓慧,方方,等.左乙拉西坦口服液治疗儿童部分性癫痫的临床研究[J].中国临床药理学杂志,2016,32(19):1753-1755.
[8]钱燕群,袁庆芳.左乙拉西坦治疗中老年癫痫患者的临床疗效及其对骨密度的影响[J].临床和实验医学杂志,2017,16(3):266-268.
[9]刘远昌.两种抗癫痫单药方案对部分性发作癫痫患儿临床疗效及安全性[J].临床军医杂志,2017,45(11):1171-1173.
[10]侯蕴祈,麦慧玲,石海琴,等.左乙拉西坦治疗部分性癫痫发作121例的临床疗效及对脑电图的影响[J].脑与神经疾病杂志,2016,24(3):177-181.