人参及人参皂苷镇痛作用的研究进展
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摘要
目的综述人参及人参皂苷镇痛作用的研究进展。方法通过检索国内外文献54篇,着重阐述人参、人参皂苷以及人参单体皂苷的镇痛作用。.结果常用的阿片类药物、非甾体类抗炎药以及各种类型的癌症治疗佐剂在镇痛的同时会给患者带来不良反应。人参及活性成分人参皂苷具有一定的镇痛作用,且不具有常用药物的成瘾性。结论人参及人参皂苷镇痛作用的研究尚处于起步阶段,未来我们应将人参皂苷的镇痛作用与抗癌作用相结合,为天然产物的研究与开发提供有价值的参考。
Objective To reviewed the research progress of analgesic effects of Panax ginseng and Ginsenosides.Methods Pain,antinociceptive effect of Panax ginseng and ginsenosides were mainly discussed by searching 54 domestic and foreign literatures.Results Various kinds of anticancer reagents,such as non-steroidal anti-inflammatory drugs and opioids,had great side effect clinically.Some studies found that ginsenosides and active components of ginseng had antinociceptive effect and were non-addictive.Conclusion The analgesic effect of Panax ginseng and ginsenosides is still in its infancy.We will combine the analgesic with anticancer effect of Panax ginseng and ginsenosides in the future,which provides valuable reference for the research and development of natural products.
Objective To reviewed the research progress of analgesic effects of Panax ginseng and Ginsenosides.Methods Pain,antinociceptive effect of Panax ginseng and ginsenosides were mainly discussed by searching 54 domestic and foreign literatures.Results Various kinds of anticancer reagents,such as non-steroidal anti-inflammatory drugs and opioids,had great side effect clinically.Some studies found that ginsenosides and active components of ginseng had antinociceptive effect and were non-addictive.Conclusion The analgesic effect of Panax ginseng and ginsenosides is still in its infancy.We will combine the analgesic with anticancer effect of Panax ginseng and ginsenosides in the future,which provides valuable reference for the research and development of natural products.
引文
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[10] 吴普.神农本草经[M].北京:商务印书馆,1955:19-20.
[11] VUKSAN V,SIEVENPIPER J L.Herbal remedies in the management of diabetes:lessons learned from the study of ginseng[J].Nutr Metab Cardiovasc Dis,2005,15(3):149-160.
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[16] 徐琲琲,刘纯青,马涛,等.人参皂苷Re对MPTP致帕金森病模型小鼠多巴胺能神经元的保护作用[J].沈阳药科大学学报,2005,22(1):36-44.
[17] 霍记平,黄凯,赵志刚,等.人参皂苷对心血管疾病的药理作用和药代动力学特征[J].药品评价,2014,11(18):11-15.
[18] 孙思,陈亮,王鑫,等.三七不同炮制品中抑制血管紧张素转化酶活性差异及人参皂苷Rg1和Rb1的含量测定[J].沈阳药科大学学报,2016,33(2):127-130,139.
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[20] 赵琛,苏光悦,赵余庆.人参皂苷及其衍生物抗结肠癌作用及机制的研究进展[J].中草药,2015,46(16):2477-2483.
[21] 连晓媛,张治针,池彬彬,等.人参二醇皂苷Rb组分在制备防治疼痛药物中的应用:201710737229.7[P].2017-12-08.
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[24] 陈英红,王颖,姜瑞芝,等.一种肠溶人参糖蛋白微丸在制备镇痛镇静药物中的应用:201610344500.6[P].2016-08-10.
[25] 赵国玺.一种化瘀止痛颗粒剂及其制备方法:03144224.2[P].2005-03-09.
[26] 宗立诰.通痹活血镇痛膏:03139135.4[P].2006-02-22.
[27] 向国强,向美润.一种治疗癌症疼痛的中药组合物及制备方法:201610448405.0[P].2017-02-15.
[28] 林海燕.一种治疗牙周炎的药物组合物:201610821325.5[P].2017-02-22.
[29] 秦建平,吴建雄,李家春,等.散结镇痛胶囊中皂苷类成分的指纹图谱研究和多指标成分定量测定[J].世界科学技术:中医药现代化,2013,15(9):1980-1984.
[30] 张广仁,吴云,吴莎,等.HPLC- UV-ELSD 同时测定散结镇痛胶囊中5个指标成分含量[J].中国实验方剂学杂志,2015,21(5):66-68.
[31] 易灿玲,张德忠,秦捷,等.高效液相色谱法同谱测定化瘀镇痛胶囊中4种皂苷类成分含量[J].湖北中医杂志,2014,36(12):68-69.
[32] 吴瑕,陈东辉,雷玲,等.竹节人参抗炎镇痛作用研究[J].中药药理与临床,2007,23(1):43-45.
[33] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Effects of vietnamese ginseng on opioid agonist-and conditioned fear stress-induced antinociception[J].Phytomedicine,1996,3(1):33-39.
[34] WANG Y,CHEN Y,XU H,et al.Analgesic effects of glycoproteins from Panax ginseng root in mice[J].J Ethnopharmacol,2013,148(3):946-950.
[35] LEE J H,LEE J H,LEE Y M,et al.Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals[J].Food Chem Toxicol,2008,46(12):3749-3752.
[36] 张纯武,滕红林,柳献云,等.人参皂甙对强直性脊柱炎镇痛和抗炎作用的实验研究[J].浙江中医杂志,2005,40(9):402-403.
[37] HAHN J,NAH S Y,NAH J J,et al.Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons[J].Neuroscience Letters,2000,287:45-48.
[38] NAH J J,HAHN J H,CHUNG S,et al.Effect of ginsenosides,active components of ginseng,on capsaicin-induced pain-related behavior[J].Neuropharmacology,2000,39:2180-2184.
[39] NEMMANI K V,RAMARAO P.Ginseng total saponin potentiates acute U-50,488H-induced analgesia and inhibits tolerance to U-50,488H-induced analgesia in mice[J].Pharmacology,Biochemistry and Behavior,2002,72:1-6.
[40] KIM W J,KANG H,KIM J E,et al.Effect of intraperitoneal administered ginseng total saponins on hyperalgesia induced by repeated intramuscular injection of acidic saline in rats[J].J Med Food,2014,17(6):657-662.
[41] KIM W J,KANG H,CHOI G J,et al.Antihyperalgesic effects of ginseng total saponins in a rat model of incisional pain[J].Journal of Surgical Research,2014,187(1):256-258.
[42] SHIN Y H,KIM S C,HAN J W,et al.Study on Ginseng protopanaxadiol and protopanaxatriol saponins-induced antinociception[J].Korean J of Physiology & Pharmacology,1997,1:143-149.
[43] SUH H W,SONG D K,KIM Y H.Effects of ginsenosides injected intrathecally or intracerebroventricularly on antinociception induced by morphine administered intracerebroventricularly in the mouse[J].Gen Pharmac,1997,29(5):873-877.
[44] CHOI S S,LEE J K,SUH H W.Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse[J].Biol Pharm Bull,2003,26(6):858-861.
[45] JUNG S Y,CHOI S,KO Y S,et al.Effects of ginsenosides on Vanilloid Receptor(VR1)channels expressed in xenopus oocytes[J].Molecules and Cells,2001,12(3):342-346.
[46] MOGIL J S,SHIN Y H,MCCLESKEY E W,et al.Ginsenoside Rf,a trace component of ginseng root,produces antinociception in mice[J].Brain Research,1998,792:218-228.
[47] 张文生,刘晓丽,王胜兰,等.人参皂苷Rf的新应用:201410709529.0[P].2015-03-04.
[48] NEMMANI K V S,RAMARAO P.Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice[J].Life Sciences,2003,72:759-768.
[49] 胡楚旋,刘洁,郭小东.人参皂苷Rg1镇痛抗炎实验研究[J].中药材,2013,36(3):464-467.
[50] 穆艳月,景原媛,于泳浩.鞘内注射人参皂苷Rg1对关节炎慢性吗啡耐受大鼠谷氨酸转运体水平的影响[J].中国中西医结合杂志,2012,32(11):1539-1542.
[51] 谢暕.人参皂苷 Rg1 抗炎、镇痛作用及其作用机制[J].中国医院药学杂志,2013,33(19):1592-1597.
[52] AHN E J,CHOI G J,KANG H,et al.Antinociceptive effects of ginsenoside Rg3 in a rat model of incisional pain[J].Eur Surg Res,2016,57(3/4):211-223.
[53] NGUYEN T T,MATSUMOTO K,YAMASAKIVV K,et al.Involvement of supraspinal Gaba receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice[J].Life Sciences,1997,61(4):427-436.
[54] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Crude sponin extracted from Vietnamese ginseng and its major constituent majonoside-R2 attenuate the psychological stress- and foot-shock stress-induced antinociception in mice[J].Pharmacology Biochemistry and Behavior,1995,52(2):427-432.
[55] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Majonoside-R2,a major constituent of vietnamese ginseng,attenuates opioid-induced antinociception[J].Pharmacology Biochemistry and Behavior,1997,57:285-291.
[56] SHIN Y H,JUNG O M,NAH J J,et al.Ginsenosides that produce differential antinociception in mice[J].General Pharmacology,1999,32:653-659.
[2] CLEELAND C S,GONIN R,HATFIELD A K,et al.Pain and its treatment in outpatients with metastatic cancer[J].N Engl J Med,1994,330:592-596.
[3] TWYCROSS R G.Optimal pharmacological control of chronic cancer pain[J].Recent Results Cancer Res,1988,108:9-17.
[4] MOHIDE E A,ROYLE J A,MONTEMURO M,et al.Assessing the quality of cancer pain management[J].Palliat Care,1988,4:9-15.
[5] 田明清,高崇荣.关于完善疼痛定义的探讨[J].中国临床康复,2003,7(4):622-623.
[6] SHAN Y U,PENG H D,JU D W,et al.Mechanisms of treatment of cancer pain with a topical Chinese herbal formula in rats[J].Chinese Medical Journal,2009,122(17):2027-2031.
[7] 李梅.中医药学基础[M].2版.北京:中国医药科技出版社,2009:313.
[8] ZHAO H Z.Cyclopedia of Panax ginseng and American ginseng[M].Hong Kong:Rong Zhai Publishers,1998:9.
[9] LI F Y.Panax ginseng and American ginseng[M].Beijing:Chinese Agriculture Scientech Press,2006:587-591.
[10] 吴普.神农本草经[M].北京:商务印书馆,1955:19-20.
[11] VUKSAN V,SIEVENPIPER J L.Herbal remedies in the management of diabetes:lessons learned from the study of ginseng[J].Nutr Metab Cardiovasc Dis,2005,15(3):149-160.
[12] 郑兵.人参煎剂与人参皂苷对小鼠免疫功能影响的比较研究[D].沈阳:辽宁中医药大学,2012.
[13] TAN S,ZHOU F,LI N,et al.Anti-fatigue effect of ginsenoside Rb1 on postoperative fatigue syndrome induced by major small intestinal resection in rat[J].Biol Pharm Bull,2013,36(10):1634-1639.
[14] 王佳.生晒人参抗衰老作用的研究[D].延吉:延边大学,2009.
[15] CHANG Y,HUANG W J,TIEN L T,et al.Ginsenosides Rg1 and Rb1 enhance glutamate release through activation of protein kinase A in rat cerebrocortical nerve terminals(synaptosomes)[J].Eur J Pharmacol,2008,578:28-36.
[16] 徐琲琲,刘纯青,马涛,等.人参皂苷Re对MPTP致帕金森病模型小鼠多巴胺能神经元的保护作用[J].沈阳药科大学学报,2005,22(1):36-44.
[17] 霍记平,黄凯,赵志刚,等.人参皂苷对心血管疾病的药理作用和药代动力学特征[J].药品评价,2014,11(18):11-15.
[18] 孙思,陈亮,王鑫,等.三七不同炮制品中抑制血管紧张素转化酶活性差异及人参皂苷Rg1和Rb1的含量测定[J].沈阳药科大学学报,2016,33(2):127-130,139.
[19] PARK K H,SHIN H J,SONG Y B.Possible role of ginsenoside Rb1 on regulation of rat liver triglycerides[J].Biol Pharm Bull,2002,25(4):457-460.
[20] 赵琛,苏光悦,赵余庆.人参皂苷及其衍生物抗结肠癌作用及机制的研究进展[J].中草药,2015,46(16):2477-2483.
[21] 连晓媛,张治针,池彬彬,等.人参二醇皂苷Rb组分在制备防治疼痛药物中的应用:201710737229.7[P].2017-12-08.
[22] NAH S Y.Ginseng recent advances and trends[J].Ginseng Res,1997,21:1.
[23] KAKU T,MIYATA T,URUNO T,et al.Chemico-pharmacological studies on saponins of Panax ginseng C.A.Meyer.II.Pharmacological part[J].Arzneimittelforschung,1975,25:539.
[24] 陈英红,王颖,姜瑞芝,等.一种肠溶人参糖蛋白微丸在制备镇痛镇静药物中的应用:201610344500.6[P].2016-08-10.
[25] 赵国玺.一种化瘀止痛颗粒剂及其制备方法:03144224.2[P].2005-03-09.
[26] 宗立诰.通痹活血镇痛膏:03139135.4[P].2006-02-22.
[27] 向国强,向美润.一种治疗癌症疼痛的中药组合物及制备方法:201610448405.0[P].2017-02-15.
[28] 林海燕.一种治疗牙周炎的药物组合物:201610821325.5[P].2017-02-22.
[29] 秦建平,吴建雄,李家春,等.散结镇痛胶囊中皂苷类成分的指纹图谱研究和多指标成分定量测定[J].世界科学技术:中医药现代化,2013,15(9):1980-1984.
[30] 张广仁,吴云,吴莎,等.HPLC- UV-ELSD 同时测定散结镇痛胶囊中5个指标成分含量[J].中国实验方剂学杂志,2015,21(5):66-68.
[31] 易灿玲,张德忠,秦捷,等.高效液相色谱法同谱测定化瘀镇痛胶囊中4种皂苷类成分含量[J].湖北中医杂志,2014,36(12):68-69.
[32] 吴瑕,陈东辉,雷玲,等.竹节人参抗炎镇痛作用研究[J].中药药理与临床,2007,23(1):43-45.
[33] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Effects of vietnamese ginseng on opioid agonist-and conditioned fear stress-induced antinociception[J].Phytomedicine,1996,3(1):33-39.
[34] WANG Y,CHEN Y,XU H,et al.Analgesic effects of glycoproteins from Panax ginseng root in mice[J].J Ethnopharmacol,2013,148(3):946-950.
[35] LEE J H,LEE J H,LEE Y M,et al.Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals[J].Food Chem Toxicol,2008,46(12):3749-3752.
[36] 张纯武,滕红林,柳献云,等.人参皂甙对强直性脊柱炎镇痛和抗炎作用的实验研究[J].浙江中医杂志,2005,40(9):402-403.
[37] HAHN J,NAH S Y,NAH J J,et al.Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons[J].Neuroscience Letters,2000,287:45-48.
[38] NAH J J,HAHN J H,CHUNG S,et al.Effect of ginsenosides,active components of ginseng,on capsaicin-induced pain-related behavior[J].Neuropharmacology,2000,39:2180-2184.
[39] NEMMANI K V,RAMARAO P.Ginseng total saponin potentiates acute U-50,488H-induced analgesia and inhibits tolerance to U-50,488H-induced analgesia in mice[J].Pharmacology,Biochemistry and Behavior,2002,72:1-6.
[40] KIM W J,KANG H,KIM J E,et al.Effect of intraperitoneal administered ginseng total saponins on hyperalgesia induced by repeated intramuscular injection of acidic saline in rats[J].J Med Food,2014,17(6):657-662.
[41] KIM W J,KANG H,CHOI G J,et al.Antihyperalgesic effects of ginseng total saponins in a rat model of incisional pain[J].Journal of Surgical Research,2014,187(1):256-258.
[42] SHIN Y H,KIM S C,HAN J W,et al.Study on Ginseng protopanaxadiol and protopanaxatriol saponins-induced antinociception[J].Korean J of Physiology & Pharmacology,1997,1:143-149.
[43] SUH H W,SONG D K,KIM Y H.Effects of ginsenosides injected intrathecally or intracerebroventricularly on antinociception induced by morphine administered intracerebroventricularly in the mouse[J].Gen Pharmac,1997,29(5):873-877.
[44] CHOI S S,LEE J K,SUH H W.Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse[J].Biol Pharm Bull,2003,26(6):858-861.
[45] JUNG S Y,CHOI S,KO Y S,et al.Effects of ginsenosides on Vanilloid Receptor(VR1)channels expressed in xenopus oocytes[J].Molecules and Cells,2001,12(3):342-346.
[46] MOGIL J S,SHIN Y H,MCCLESKEY E W,et al.Ginsenoside Rf,a trace component of ginseng root,produces antinociception in mice[J].Brain Research,1998,792:218-228.
[47] 张文生,刘晓丽,王胜兰,等.人参皂苷Rf的新应用:201410709529.0[P].2015-03-04.
[48] NEMMANI K V S,RAMARAO P.Ginsenoside Rf potentiates U-50,488H-induced analgesia and inhibits tolerance to its analgesia in mice[J].Life Sciences,2003,72:759-768.
[49] 胡楚旋,刘洁,郭小东.人参皂苷Rg1镇痛抗炎实验研究[J].中药材,2013,36(3):464-467.
[50] 穆艳月,景原媛,于泳浩.鞘内注射人参皂苷Rg1对关节炎慢性吗啡耐受大鼠谷氨酸转运体水平的影响[J].中国中西医结合杂志,2012,32(11):1539-1542.
[51] 谢暕.人参皂苷 Rg1 抗炎、镇痛作用及其作用机制[J].中国医院药学杂志,2013,33(19):1592-1597.
[52] AHN E J,CHOI G J,KANG H,et al.Antinociceptive effects of ginsenoside Rg3 in a rat model of incisional pain[J].Eur Surg Res,2016,57(3/4):211-223.
[53] NGUYEN T T,MATSUMOTO K,YAMASAKIVV K,et al.Involvement of supraspinal Gaba receptors in majonoside-R2 suppression of clonidine-induced antinociception in mice[J].Life Sciences,1997,61(4):427-436.
[54] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Crude sponin extracted from Vietnamese ginseng and its major constituent majonoside-R2 attenuate the psychological stress- and foot-shock stress-induced antinociception in mice[J].Pharmacology Biochemistry and Behavior,1995,52(2):427-432.
[55] HUONG N T T,MATSUMOTO K,YAMASAKI K,et al.Majonoside-R2,a major constituent of vietnamese ginseng,attenuates opioid-induced antinociception[J].Pharmacology Biochemistry and Behavior,1997,57:285-291.
[56] SHIN Y H,JUNG O M,NAH J J,et al.Ginsenosides that produce differential antinociception in mice[J].General Pharmacology,1999,32:653-659.