miRNAs在破骨细胞中的研究进展
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摘要
破骨细胞起源于造血干细胞,是体内一种负责骨吸收的骨特异性多核细胞,在骨代谢平衡的调控中起着重要作用。破骨细胞的分化形成及功能活性异常可引起一系列临床疾病,而其分化形成过程受到多种因子的调控,近年来越来越多研究聚焦于miRNAs对破骨细胞分化形成过程的调控作用。因此,本文主要对影响破骨细胞分化形成的相关miRNAs进行综述,为后续相关研究提供参考。
Osteoclasts originate from hematopoietic stem cells and are bone-specific multinucleated cells responsible for bone resorption. Osteoclasts play an important role in the regulation of bone metabolism bal-ance. The abnormal formation and differentiation of osteoclast could result in a series of clinical diseases.The process of osteoclast formation and differentiation is regulated by many factors. In recent years, more and more studies have focused on the regulatory roles of miRNAs in the process of osteoclast differentiation.Here the review of the related miRNAs affecting osteoclast differentiation is provided for the future research.
Osteoclasts originate from hematopoietic stem cells and are bone-specific multinucleated cells responsible for bone resorption. Osteoclasts play an important role in the regulation of bone metabolism bal-ance. The abnormal formation and differentiation of osteoclast could result in a series of clinical diseases.The process of osteoclast formation and differentiation is regulated by many factors. In recent years, more and more studies have focused on the regulatory roles of miRNAs in the process of osteoclast differentiation.Here the review of the related miRNAs affecting osteoclast differentiation is provided for the future research.
引文
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[33]FU L L,WEN X,BAO J K,et al.MicroRNA-modulated autophagic signaling networks in cancer[J].International Journal of Biochemistry&Cell Biology,2012,44(5):733-736.
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[36]CHEN J,QIU M,DOU C,et al.MicroRNAs in bone balance and osteoporosis[J].Drug Development Research,2015,76(5):235-245.
[37]ZHAO C,SUN W,ZHANG P,et al.miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway[J].RNA Biology,2015,12(3):343-353.
[38]SUTTAMANATWONG S.MicroRNAs in bone development and their diagnostic and therapeutic potentials in osteoporosis[J].Connective Tissue Research,2017,58(1):90-102.
[39]GUO L J,LIAO L,YANG L,et al.miR-125a TNF receptorassociated factor 6 to inhibit osteoclastogenesis[J].Experimental Cell Research,2014,321(2):142-152.
[40]SUN Y M,LIN K Y,CHEN Y Q.Diverse functions of miR-125family in different cell contexts[J].Journal of Hematology&Oncology,2013,6:6.
[41]TAKAYANAGI H,KIM S,MATSUO K,et al.RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta[J].Nature,2002,416(6882):744-749.
[42]ZHANG J,ZHAO H,CHEN J,et al.Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1and MITF[J].FEBS Letters,2012,586(19):3255-3262.
[43]NAKASA T,SHIBUYA H,NAGATA Y,et al.The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis[J].Arthritis&Rheumatology,2011,63(6):1582-1590.
[44]HU Y,PU Q,CUI B,et al.MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2[J].International Journal of Clinical and Experimental Pathology,2015,8(8):8921-8928.
[45]KRZESZINSKI J Y,WEI W,HUYNH H,et al.miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2[J].Nature,2014,512(7515):431-435.
[46]CHEN C,CHENG P,XIE H,et al.miR-503 regulates osteoclastogenesis via targeting RANK[J].Journal of Bone and Mineral Research,2014,29(2):338-347.
[47]JI X,CHEN X,YU X.MicroRNAs in osteoclastogenesis and function:potential therapeutic targets for osteoporosis[J].International Journal of Molecular Sciences,2016,17(3):349.
[2]BARTEL D P.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
[3]HU R,LI H,LIU W,et al.Targeting miRNAs in osteoblast differentiation and bone formation[J].Expert Opinion on Therapeutic Targets,2010,14(10):1109-1120.
[4]FRIEDMAN R C,BURGE C B.MicroRNA target finding by comparative genomics[J].Methods in Molecular Biology,2014,1097:457-476.
[5]CAPPARIELLO A,MAURIZI A,VEERIAH V,et al.The great beauty of the osteoclast[J].Archives of Biochemistry and Biophysics,2014,558:70-78.
[6]LIZNEVA D,YUEN T,SUN L,et al.Emerging concepts in the epidemiology,pathophysiology,and clinical care of postmenopausal osteoporosis[J].Matrix Biology,2018,42(10):269-291.
[7]ZHANG B,WANG Q,PAN X.MicroRNAs and their regulatory roles in animals and plants[J].Journal of Cellular Physiology,2007,210(2):279-289.
[8]LEE R C,FEINBAUM R L,AMBROS V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
[9]WIGHTMAN B,HA I,RUVKUN G.Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C.elegans[J].Cell,1993,75(5):855-862.
[10]LIM L P,LAU N C,WEINSTEIN E G,et al.The microRNAs of Caenorhabditis elegans[J].Genes&Development,2003,17(8):991-1008.
[11]LEE R C,AMBROS V.An extensive class of small RNAs in Caenorhabditis elegans[J].Science,2001,294(5543):862-864.
[12]KROL J,KRZYZOSIAK W J.Structural aspects of microRNAbiogenesis[J].IUBMB Life,2004,56(2):95-100.
[13]SIOMI H,SIOMI M C.Posttranscriptional regulation of microRNA biogenesis in animals[J].Molecular Cell,2010,38(3):323-332.
[14]CHOUDHURI S.Small noncoding RNAs:biogenesis,function,and emerging significance in toxicology[J].Journal of Biochemical and Molecular Toxicology,2010,24(3):195-216.
[15]DAUGAARD I,HANSEN T B.Biogenesis and function of agoassociated RNAs[J].Trends in Genetics,2017,33(3):208-219.
[16]DAVIS-DUSENBERY B N,HATA A.Mechanisms of control of microRNA biogenesis[J].Journal of Biochemistry,2010,148(4):381-392.
[17]TREIBER T,TREIBER N,MEISTER G.Regulation of microRNA biogenesis and function[J].Thrombosis and Haemostasis,2012,107(4):605-610.
[18]SCHRATT G.Fine-tuning neural gene expression with microR-NAs[J].Current Opinion in Neurobiology,2009,19(2):213-219.
[19]CHARLES J F,ALIPRANTIS A O.Osteoclasts:more than‘bone eaters’[J].Trends in Molecular Medicine,2014,20(8):449-459.
[20]ONO T,NAKASHIMA T.Recent advances in osteoclast biology[J].Histochemistry and Cell Biology,2018,149(4):325-341.
[21]JIMI E.The role of osteoclastic bone resorption on bone remodeling[J].Clinical Calcium,2017,27(12):1689-1695.
[22]SUGATANI T,VACHER J,HRUSKA K A.A microRNA expression signature of osteoclastogenesis[J].Blood,2011,117(13):3648-3657.
[23]MIZOGUCHI F,IZU Y,HAYATA T,et al.Osteoclast-specific dicer gene deficiency suppresses osteoclastic bone resorption[J].Journal of Cellular Biochemistry,2010,109(5):866-875.
[24]SUGATANI T,HRUSKA K A.Impaired micro-RNA pathways diminish osteoclast differentiation and function[J].The Journal of Biological Chemistry,2009,284(7):4667-4678.
[25]FRANCESCHETTI T,DOLE N S,KESSLER C B,et al.Pathway analysis of microRNA expression profile during murine osteoclastogenesis[J].PLoS One,2014,9(9):e107262.
[26]LI S,LIANG Z,XU L,et al.MicroRNA-21:a ubiquitously expressed pro-survival factor in cancer and other diseases[J].Molecular and Cellular Biochemistry,2012,360(1-2):147-158.
[27]MITCHELL P S,PARKIN R K,KROH E M,et al.Circulating microRNAs as stable blood-based markers for cancer detection[J].Proceedings of the National Academy of Sciences USA,2008,105(30):10513-10518.
[28]FRANCESCHETTI T,KESSLER C B,LEE S K,et al.miR-29promotes murine osteoclastogenesis by regulating osteoclast commitment and migration[J].The Journal of Biological Chemistry,2013,288(46):33347-33360.
[29]WANG F S,CHUANG P C,LIN C L,et al.MicroRNA-29a protects against glucocorticoid-induced bone loss and fragility in rats by orchestrating bone acquisition and resorption[J].Arthritis&Rheumatology,2013,65(6):1530-1540.
[30]GENNARI L,BIANCIARDI S,MERLOTTI D.MicroRNAs in bone diseases[J].Osteoporosis International,2017,28(4):1191-1213.
[31]GE D W,WANG W W,CHEN H T,et al.Functions of microRNAs in osteoporosis[J].European Review for Medical and Pharmacological Sciences,2017,21(21):4784-4789.
[32]TANG P,XIONG Q,GE W,et al.The role of microRNAs in osteoclasts and osteoporosis[J].RNA Biology,2014,11(11):1355-1363.
[33]FU L L,WEN X,BAO J K,et al.MicroRNA-modulated autophagic signaling networks in cancer[J].International Journal of Biochemistry&Cell Biology,2012,44(5):733-736.
[34]HESSAM S,SAND M,SKRYGAN M,et al.Expression of miR-NA-155,miRNA-223,miRNA-31,miRNA-21,miRNA-125b,and miRNA-146a in the inflammatory pathway of hidradenitis suppurativa[J].Inflammation,2017,40(2):464-472.
[35]CHENG P,CHEN C,HE H B,et al.miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B[J].Journal of Bone and Mineral Research,2013,28(5):1180-1190.
[36]CHEN J,QIU M,DOU C,et al.MicroRNAs in bone balance and osteoporosis[J].Drug Development Research,2015,76(5):235-245.
[37]ZHAO C,SUN W,ZHANG P,et al.miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway[J].RNA Biology,2015,12(3):343-353.
[38]SUTTAMANATWONG S.MicroRNAs in bone development and their diagnostic and therapeutic potentials in osteoporosis[J].Connective Tissue Research,2017,58(1):90-102.
[39]GUO L J,LIAO L,YANG L,et al.miR-125a TNF receptorassociated factor 6 to inhibit osteoclastogenesis[J].Experimental Cell Research,2014,321(2):142-152.
[40]SUN Y M,LIN K Y,CHEN Y Q.Diverse functions of miR-125family in different cell contexts[J].Journal of Hematology&Oncology,2013,6:6.
[41]TAKAYANAGI H,KIM S,MATSUO K,et al.RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta[J].Nature,2002,416(6882):744-749.
[42]ZHANG J,ZHAO H,CHEN J,et al.Interferon-beta-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1and MITF[J].FEBS Letters,2012,586(19):3255-3262.
[43]NAKASA T,SHIBUYA H,NAGATA Y,et al.The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis[J].Arthritis&Rheumatology,2011,63(6):1582-1590.
[44]HU Y,PU Q,CUI B,et al.MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2[J].International Journal of Clinical and Experimental Pathology,2015,8(8):8921-8928.
[45]KRZESZINSKI J Y,WEI W,HUYNH H,et al.miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2[J].Nature,2014,512(7515):431-435.
[46]CHEN C,CHENG P,XIE H,et al.miR-503 regulates osteoclastogenesis via targeting RANK[J].Journal of Bone and Mineral Research,2014,29(2):338-347.
[47]JI X,CHEN X,YU X.MicroRNAs in osteoclastogenesis and function:potential therapeutic targets for osteoporosis[J].International Journal of Molecular Sciences,2016,17(3):349.