钼靶诊断乳腺肿瘤的影像学特征及其灵敏度和特异度的研究
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摘要
目的:探讨钼靶X射线在乳腺肿瘤患者临床诊断中的应用价值及诊断灵敏度、特异度和影像学特征。方法:回顾性分析在医院就诊的96例乳腺肿瘤患者诊断资料,所有患者分别行乳腺超声诊断和钼靶X射线检查,以最终手术病理诊断结果为金标准,观察乳腺超声诊断及钼靶X射线诊断乳腺肿瘤的灵敏度、特异度和准确率,分析钼靶X射线诊断乳腺肿瘤的影像学特征。结果:钼靶X射线检查与手术病理结果的准确率比较,差异无统计学意义(x~2=0.264,P>0.05);乳腺超声诊断与手术病理、钼靶X射线诊断比较,差异有统计学意义(F=5.697,F=4.225;P<0.05);钼靶X射线与手术病理诊断的灵敏度和特异度比较,差异无统计学意义(F=0.415,F=0.129;P>0.05);乳腺超声诊断与手术病理、钼靶X射线诊断差异有统计学意义(F=394;F=506,F=4.697,F=7.120;P<0.05)。钼靶X射线检查乳腺肿瘤患者的影像学特征中,以肿块为主45例(占46.88%),以钙化为主40例(占41.67%),呈现钙化合并肿块11例(占11.46%)。结论:钼靶X射线应用于乳腺肿瘤诊断效果显著,有较高诊断准确率、灵敏度和特异度,具有一定的临床应用价值。
Objective: To investigate the application value, sensitivity and specificity of diagnosis, and imaging features of mammography with molybdenum target in the clinical diagnosis for patients with breast cancer. Methods: A retrospective analysis of 96 patients with breast tumor in the hospital for diagnosis were implemented, and all of patients underwent ultrasound diagnosis and the diagnosis of mammography with molybdenum target for breast, respectively. At last, the surgically pathological diagnosis was used as gold standard to observe the sensitivity, specificity and accuracy of ultrasound diagnosis and mammography with molybdenum target in diagnosing tumor of breast, respectively. And the imaging feature of mammography with molybdenum target in diagnosing was further analyzed. Results: There was no significant difference in accuracy between mammography with molybdenum target and surgical pathology(x2=0.264, P>0.05). The differences of accuracy between ultrasound diagnosis and surgical pathology and between that and mammography with molybdenum target were significant(F=5.697, F=4.225, P<0.05), respectively. The differences of diagnostic sensitivity and specificity between mammography with molybdenum target and surgical pathology were no significant(F=0.415, F=0.129, P>0.05), respectively. While the differences of those between ultrasound diagnosis and surgical pathology and between that and mammography with molybdenum target were significant(F=394, F=506, F=4.697, F=7.120, P<0.05). In the imaging features of mammography with molybdenum target in diagnosing patients with tumor of breast, lumps were main in 45 cases(46.88%), and calcifications were main in 40 cases(41.67%), and calcifications combined with lumps appeared in 11 cases(11.46%). Conclusion: The application of molybdenum with molybdenum target in diagnosing breast tumors is significant, and it has higher accuracy, sensitivity and specificity of diagnosis. Therefore, it has certain clinical application value.
Objective: To investigate the application value, sensitivity and specificity of diagnosis, and imaging features of mammography with molybdenum target in the clinical diagnosis for patients with breast cancer. Methods: A retrospective analysis of 96 patients with breast tumor in the hospital for diagnosis were implemented, and all of patients underwent ultrasound diagnosis and the diagnosis of mammography with molybdenum target for breast, respectively. At last, the surgically pathological diagnosis was used as gold standard to observe the sensitivity, specificity and accuracy of ultrasound diagnosis and mammography with molybdenum target in diagnosing tumor of breast, respectively. And the imaging feature of mammography with molybdenum target in diagnosing was further analyzed. Results: There was no significant difference in accuracy between mammography with molybdenum target and surgical pathology(x2=0.264, P>0.05). The differences of accuracy between ultrasound diagnosis and surgical pathology and between that and mammography with molybdenum target were significant(F=5.697, F=4.225, P<0.05), respectively. The differences of diagnostic sensitivity and specificity between mammography with molybdenum target and surgical pathology were no significant(F=0.415, F=0.129, P>0.05), respectively. While the differences of those between ultrasound diagnosis and surgical pathology and between that and mammography with molybdenum target were significant(F=394, F=506, F=4.697, F=7.120, P<0.05). In the imaging features of mammography with molybdenum target in diagnosing patients with tumor of breast, lumps were main in 45 cases(46.88%), and calcifications were main in 40 cases(41.67%), and calcifications combined with lumps appeared in 11 cases(11.46%). Conclusion: The application of molybdenum with molybdenum target in diagnosing breast tumors is significant, and it has higher accuracy, sensitivity and specificity of diagnosis. Therefore, it has certain clinical application value.
引文
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[2]刘巧珍,唐英杰,崔志利,等.160例早期乳腺癌患者高频超声与钼钯X线诊断结果分析[J].中国妇幼保健,2018,33(7):20-23.
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[4]李瑞青,杜稼苓,孙鹤庆,等.钼靶X线假阴性乳腺癌患者临床病理学特点的回顾性分析[J].中国现代医学杂志,2016,26(17):94-97.
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[9]薛晨晖,赵兰空,赵吉平,等.乳腺钼靶联合MRI检查在老年乳腺癌诊断中的价值[J].肿瘤学杂志,2017,23(1):74-76.
[10]付丽媛,梁永刚,陈自谦,等.全数字化乳腺X射线成像系统质量控制检测智能评价系统的研究[J].中国医学装备,2017,14(12):31-39.
[11]徐峰,李梦新,Jusko P,等.电阻抗断层成像与乳房超声及钼靶在诊断乳腺良恶性病变中的对照观察[J].中华医学杂志,2017,97(18):19-22.
[12]李慧敏,李明慧,贺玲.超声萤火虫成像技术与X线钼靶在乳腺微钙化的检测的对照研究[J].中国医药导刊,2017,19(1):1-2.
[13]董慧萍,周艳芳,凌冰.乳腺钼靶X射线摄影和超声诊断乳腺导管内癌的临床价值[J].中国妇幼保健,2017,32(18):4583-4585.
[14]Kim WH,Chang JM,Koo HR,et al.Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis[J].Acta Radiol,2016,58(2):148-155.
[15]Yu X,Hu G,Zhang Z,et al.Retrospective and comparative analysis of 99Tcm-Sestamibi breast specific gamma imaging versus mammography,ultrasound,and magnetic resonance imaging for the detection of breast cancer in Chinese women[J].BMCCancer,2016,16(1):450.
[16]Razek NA,Essa AE.Role of low dose state of multislice CT mammography in the evaluation of postoperative and post-radiation changes[J].
[17]Egypt J RadiNuclMed,2016,47(4):1709-1720.程任捷,唐文成.多种超声技术与X射线钼靶联合诊断乳腺癌的应用价值[J].中国临床研究,2017,30(8):1123-1125.
[2]刘巧珍,唐英杰,崔志利,等.160例早期乳腺癌患者高频超声与钼钯X线诊断结果分析[J].中国妇幼保健,2018,33(7):20-23.
[3]马杜丰,周家德.多种影像学联合检查诊断早期乳腺癌的临床分析[J].中国现代普通外科进展,2016,19(7):564-566.
[4]李瑞青,杜稼苓,孙鹤庆,等.钼靶X线假阴性乳腺癌患者临床病理学特点的回顾性分析[J].中国现代医学杂志,2016,26(17):94-97.
[5]中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2007版)[J].中国癌症杂志,2009,19(6):410-428.
[6]李贤华,王兵.乳腺钼靶X射线摄影检查联合磁共振成像诊断乳腺导管原位癌的有效性[J].中国计划生育和妇产科,2018,9(2):15-19.
[7]Phi XA,Saadatmand S,DeBock GH,et al.Contribution of mammography to MRIscreening in BRCA mutation carriers by BRCAstatus and age:Individual patient data metaanalysis[J].Br J Cancer,2016,114(6):631-637.
[8]张振,冯云,李振宇,等.多模态MRI联合不同影像学方法对乳腺良、恶性病变的鉴别诊断价值[J].中国CT和MRI杂志,2018,8(4):22-26.
[9]薛晨晖,赵兰空,赵吉平,等.乳腺钼靶联合MRI检查在老年乳腺癌诊断中的价值[J].肿瘤学杂志,2017,23(1):74-76.
[10]付丽媛,梁永刚,陈自谦,等.全数字化乳腺X射线成像系统质量控制检测智能评价系统的研究[J].中国医学装备,2017,14(12):31-39.
[11]徐峰,李梦新,Jusko P,等.电阻抗断层成像与乳房超声及钼靶在诊断乳腺良恶性病变中的对照观察[J].中华医学杂志,2017,97(18):19-22.
[12]李慧敏,李明慧,贺玲.超声萤火虫成像技术与X线钼靶在乳腺微钙化的检测的对照研究[J].中国医药导刊,2017,19(1):1-2.
[13]董慧萍,周艳芳,凌冰.乳腺钼靶X射线摄影和超声诊断乳腺导管内癌的临床价值[J].中国妇幼保健,2017,32(18):4583-4585.
[14]Kim WH,Chang JM,Koo HR,et al.Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis[J].Acta Radiol,2016,58(2):148-155.
[15]Yu X,Hu G,Zhang Z,et al.Retrospective and comparative analysis of 99Tcm-Sestamibi breast specific gamma imaging versus mammography,ultrasound,and magnetic resonance imaging for the detection of breast cancer in Chinese women[J].BMCCancer,2016,16(1):450.
[16]Razek NA,Essa AE.Role of low dose state of multislice CT mammography in the evaluation of postoperative and post-radiation changes[J].
[17]Egypt J RadiNuclMed,2016,47(4):1709-1720.程任捷,唐文成.多种超声技术与X射线钼靶联合诊断乳腺癌的应用价值[J].中国临床研究,2017,30(8):1123-1125.