GC-MS和LC-MS技术用于食品接触高分子中非有意添加物的检测研究
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摘要
食品接触材料在生产和使用过程中不可避免的要引入大量的非有意添加物(non intentionally added substance,NIAS),这些NIAS来源复杂且成分未知,给食品安全带来极大风险。本文对食品接触材料中NIAS来源进行了分析,对GC-M(Gas Chromatography-Mass Spectrometry)S和LC-MS(Liquid Chromatography-Mass Spectrometry)技术在NIAS检测方面的应用按照可挥发性NIAS和不可挥发性NIAS两个方面进行了介绍,为食品接触材料的安全评估提供依据。
This paper discussed the main sources of non-intentionally added substance(NIAS)in food contact materials.The application of GC-MS and LC-MS in determining NIAS is introduced in the case of volatile and non-volatile respectively.
This paper discussed the main sources of non-intentionally added substance(NIAS)in food contact materials.The application of GC-MS and LC-MS in determining NIAS is introduced in the case of volatile and non-volatile respectively.
引文
[1]钟怀宁,陈俊骐,冯婕莉,等.食品接触材料中非有意添加物的安全评估[J].中国食品卫生杂志,2017,29(2):238-243.
[2]杨岳平,胡长鹰,李克亚,等.毒理学关注阈值方法在食品接触材料风险评估中的应用[J].食品科学,2015,36(23):334-339.
[3]Felix J S,Isella F,Bosetti O,et al.Analytical tools for identification of non-intentionally added substances(NIAS)coming from polyurethane adhesives in multilayer packaging materials and their migration into food stimulants[J].Anal Bioanal Chem,2012,403(10):2869-2882.
[4]王燕飞,陈莉,陈盛,等.食品接触材料中丙烯腈的检测研究进展[J].食品安全导刊,2017,36:61-62.
[5]王芳颖.食品接触用PET薄膜的相关介绍及其在产品安全方面的关注点[J].食品安全导刊,2016,22:52-55.
[6]高建国,高永刚,王树峰,等.热环境下食品接触材料中双酚A的释放及热分解动力学研究[J].分析测试学报,2012,31:268-274.
[7]赵龙山,马晨阳,宁雪娆,等.色质联用技术在污水中药物残留检测的研究进展[J].沈阳医科大学学报,2015,9:739-748.
[8]张涛.色质联用技术在毒品检验中的应用[J].云南警官学院学报,2006,2:50-52.
[9]彭涛,李晓娟,代汉慧,等.色质联用技术在保健食品违禁化学物质分析中的应用[J].质谱学报,2012,33(6):370-379.
[10]丘苑新,叶盛英,余凯.60 Coγ辐照对抽真空复合包装材料性能影响初探[J].核农学报,2007,21(4):383-386.
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[13]戴岳,段敏,李强,等.基于RASFF通报分析我国食品接触用金属材料及制品安全[J].食品安全质量检测学报,2017,8(12):4865-4869.
[14]李晨.甲基丙烯酸甲酯阴离子聚合的研究及副反应的控制[D].上海:华东理工大学,2011:25-26.
[15]武荣瑞.聚对苯二甲酸乙二酯合成过程中的副反应[J].北京化工学院学报,1981,01:101-107.
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[20]Salafranca J,Clemente I,Isella F,et al.Influence of oxygen and long term storage on the profile of volatile compounds released from polymeric multilayer food contact materials sterilized by gamma irradiation[J].Anal Chim Acta,2015,878:118-130.
[21]Casajuana N,Lacorte S.New methodology for the determination of phthalate esters,bisphenol A,bisphenol A diglycidyl ether,and nonylphenol in commercial whole mile samples[J].J Agr Food Chem,2004,52:3702-3707.
[22]Haider N,Karlsson S.Loss of chimassorb 944from LDPE and identification of additive degradation products after exposure to water,air and compost[J].Polym Degrad Stabil,2001,74:103-112.
[23]杨岳平,胡长鹰,钟怀宁,等.抗氧剂168的降解及其降解产物的测定[J].现代食品科技,2016,32(6):304-309.
[24]王美华,丛林凤.食品包装用聚乙烯树脂再生料鉴别技术研究[J].包装工程,2009,30(4):27-30.
[25]陈旭明,李婷.复合食品包装膜袋中2,4-二氨基甲苯的气-质联用测量[J].包装工程,2016,37(15):102-106.
[26]Bentayeb K,Batlle R,Romero J,et al.UPLC-MS as a powerful technique for screening the nonvolatile contaminants in recycled PET[J].Anal Bioanal Chem,2007,388:1031-1038.
[27]Canellas E,Nerin C,Moore R,et al.New UPLC coupled to mass spectrometry approaches for screening of non-volatile compounds as potential migrants from adhesives used in food packaging materials[J].Anal Chim Acta,2010,666:62-69.
[28]Bignardi C,Cavazza A,Lagana C,et al.Release of non-intentionally added substances from food contact polycarbonate:effect of ageing[J].Food Control,2017,71:329-335.
[29]Aznar M,Alfaro P,Nerin C,et al.UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials[J].Anal.Bioanal.Chem,2012,404(6-7):1945-1957.
[30]李全忠,周明辉,刘莹峰,等.液相色谱-串联质谱法测定食品接触材料中28种初级芳香胺的迁移量[J].分析化学,2013,41(1):25-30.
[31]周勇,赵凯,黄鹂,等.UPLC-MS/MS同时检测金枪鱼罐头中BPA、BADGE、BFDGE及其衍生物[J].食品工业,2016,37(3):290-294.
[32]陈益欧.苏州市主要水体、饮用水及餐饮用具壬基酚污染状况调查及其去除方法研究[D].苏州:苏州大学,2013:28-30.
[2]杨岳平,胡长鹰,李克亚,等.毒理学关注阈值方法在食品接触材料风险评估中的应用[J].食品科学,2015,36(23):334-339.
[3]Felix J S,Isella F,Bosetti O,et al.Analytical tools for identification of non-intentionally added substances(NIAS)coming from polyurethane adhesives in multilayer packaging materials and their migration into food stimulants[J].Anal Bioanal Chem,2012,403(10):2869-2882.
[4]王燕飞,陈莉,陈盛,等.食品接触材料中丙烯腈的检测研究进展[J].食品安全导刊,2017,36:61-62.
[5]王芳颖.食品接触用PET薄膜的相关介绍及其在产品安全方面的关注点[J].食品安全导刊,2016,22:52-55.
[6]高建国,高永刚,王树峰,等.热环境下食品接触材料中双酚A的释放及热分解动力学研究[J].分析测试学报,2012,31:268-274.
[7]赵龙山,马晨阳,宁雪娆,等.色质联用技术在污水中药物残留检测的研究进展[J].沈阳医科大学学报,2015,9:739-748.
[8]张涛.色质联用技术在毒品检验中的应用[J].云南警官学院学报,2006,2:50-52.
[9]彭涛,李晓娟,代汉慧,等.色质联用技术在保健食品违禁化学物质分析中的应用[J].质谱学报,2012,33(6):370-379.
[10]丘苑新,叶盛英,余凯.60 Coγ辐照对抽真空复合包装材料性能影响初探[J].核农学报,2007,21(4):383-386.
[11]Glouas A E,Riganakos K A,Kontominas M G.Effect of ionizing radiation on physicochemical and mechanical properties of commercial monolayer and multilayer semirigid plastics packaging materials[J].Radiate Phys Chem,2004,69(5):411-417.
[12]Deschens L,Arbour A,Brunet F,et al.Irradiation of a barrier film:Analysis of some mass transfer aspects[J].Radiat phys Chem,1995,46(4-6):805-808.
[13]戴岳,段敏,李强,等.基于RASFF通报分析我国食品接触用金属材料及制品安全[J].食品安全质量检测学报,2017,8(12):4865-4869.
[14]李晨.甲基丙烯酸甲酯阴离子聚合的研究及副反应的控制[D].上海:华东理工大学,2011:25-26.
[15]武荣瑞.聚对苯二甲酸乙二酯合成过程中的副反应[J].北京化工学院学报,1981,01:101-107.
[16]付鑫.气相色谱-串联质谱法检测食品包装材料中的多种有机氯农药[D].长春:吉林大学,2011:8-16.
[17]Nerin C,Alfaro P,Aznar M,et al.The challenge of identifying non-intentionally added substances from food packaging materials:A review[J].Anal Chim Acta,2013,775:14-24.
[18]Canellas E,Vera P,Nerin C.UPLC-ESI-Q-TOF-MS and GC-MS identification and quantification of non-intentionally added substances coming from biodegradable food packaging[J].Anal Bioanal Chem,2015,407(22):6781-6790.
[19]Martinez-Bueno M J,Hernando M D,Ucles S,et al.Identification of non-intentionally added substances in food packaging nano films by gas and liquid chromatography coupled to orbitrap mass spectrometry[J].Talanta,2017,172:68-77.
[20]Salafranca J,Clemente I,Isella F,et al.Influence of oxygen and long term storage on the profile of volatile compounds released from polymeric multilayer food contact materials sterilized by gamma irradiation[J].Anal Chim Acta,2015,878:118-130.
[21]Casajuana N,Lacorte S.New methodology for the determination of phthalate esters,bisphenol A,bisphenol A diglycidyl ether,and nonylphenol in commercial whole mile samples[J].J Agr Food Chem,2004,52:3702-3707.
[22]Haider N,Karlsson S.Loss of chimassorb 944from LDPE and identification of additive degradation products after exposure to water,air and compost[J].Polym Degrad Stabil,2001,74:103-112.
[23]杨岳平,胡长鹰,钟怀宁,等.抗氧剂168的降解及其降解产物的测定[J].现代食品科技,2016,32(6):304-309.
[24]王美华,丛林凤.食品包装用聚乙烯树脂再生料鉴别技术研究[J].包装工程,2009,30(4):27-30.
[25]陈旭明,李婷.复合食品包装膜袋中2,4-二氨基甲苯的气-质联用测量[J].包装工程,2016,37(15):102-106.
[26]Bentayeb K,Batlle R,Romero J,et al.UPLC-MS as a powerful technique for screening the nonvolatile contaminants in recycled PET[J].Anal Bioanal Chem,2007,388:1031-1038.
[27]Canellas E,Nerin C,Moore R,et al.New UPLC coupled to mass spectrometry approaches for screening of non-volatile compounds as potential migrants from adhesives used in food packaging materials[J].Anal Chim Acta,2010,666:62-69.
[28]Bignardi C,Cavazza A,Lagana C,et al.Release of non-intentionally added substances from food contact polycarbonate:effect of ageing[J].Food Control,2017,71:329-335.
[29]Aznar M,Alfaro P,Nerin C,et al.UPLC-Q-TOF-MS analysis of non-volatile migrants from new active packaging materials[J].Anal.Bioanal.Chem,2012,404(6-7):1945-1957.
[30]李全忠,周明辉,刘莹峰,等.液相色谱-串联质谱法测定食品接触材料中28种初级芳香胺的迁移量[J].分析化学,2013,41(1):25-30.
[31]周勇,赵凯,黄鹂,等.UPLC-MS/MS同时检测金枪鱼罐头中BPA、BADGE、BFDGE及其衍生物[J].食品工业,2016,37(3):290-294.
[32]陈益欧.苏州市主要水体、饮用水及餐饮用具壬基酚污染状况调查及其去除方法研究[D].苏州:苏州大学,2013:28-30.