摘要
目的应用Keratograph 5M眼表综合分析仪观察2型糖尿病患者泪膜功能的改变。方法选择我院内分泌科确诊的100例(200眼)糖尿病患者作为观察组,同期到我院眼科中心门诊就诊的50例(100眼)无糖尿病者作为对照组。采用Keratograph 5M眼表综合分析仪测定两组的首次泪膜破裂时间(BUTf)、平均泪膜破裂时间(BUTav)及中央泪河高度(TMHm),并分析上、下睑板腺缺失状况。同时两组均进行基础分泌试验(SIt)检查。结果观察组的BUTf及BUTav均短于照组(P <0.05)。两组的TMHm、上下睑板腺缺失状况评分比较均无统计学差异(P>0.05)。BUTf及BUTav均与SIt值呈正相关(r=0.317、0.298, P均=0.000)。结论 Keratograph 5M眼表综合分析仪可以客观、准确地分析2型糖尿病患者泪膜功能的改变,而2型糖尿病患者更容易出现泪膜功能的改变。
Objective To observe the changes of tear film function in patients with type 2 diabetes mellitus by Keratograph 5M.Methods 100 cases of patients(200 eyes) diagnosed as type 2 diabetes mellitus in endocrinology department of our hospital were selected as the observation group, 50 out-petients(100 eyes) with non-diabetes were selected as the control group. The first tear film break-up time(BUTf) and average tear film break-up time(BUTav) and middle tear meniscus height(TMHm) were detected by Keratograph 5M. The deficiency of meibomian glands were analyzed. The Schirmer Ⅰ test(SIt) were performed for both groups. Results The BUTf and BUTav of the observation group were shorter than those of the control group(P <0.05). No statistical was found in the TMHm and meibomian gland deficiency scores between the two groups(P >0.05). The BUTf and BUTav were positively related with SIt(r = 0.317, 0.298, all P = 0.000).Conclusions Keratograph 5M can directly evaluate the changes of tear film function of patients with type 2 diabetes mellitus objectively and precisely, and the tear film function of patients with type 2 diabetes mellitus changes more easily.
引文
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