原发性肾小球肾炎患者尿蛋白定量与血清内脂素、同型半胱氨酸的关系
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摘要
目的:探讨原发性肾小球肾炎(PGN)患者尿蛋白定量与血清内脂素(VF)、同型半胱氨酸(HCY)的关系。方法:选取100例PGN患者作为PGN组,依据治疗结果分为有效组(75例)和无效组(25例),同期选取门诊健康人员30例作为健康组,采用酶联免疫吸附法检测3组血清VF及HCY水平,检测24 h尿蛋白定量,分析24 h尿蛋白定量与血清VF、HCY水平的关系。结果:PGN组24 h尿蛋白定量、血清VF、HCY水平明显高于健康组,且有效组明显低于无效组(均P<0.05)。Pearson相关性分析显示,24 h尿蛋白定量与血清VF、HCY水平呈正相关(r_1=0.687,r_2=0.695,均P<0.05)。结论:血清VF、HCY水平可能与PGN的发生及其预后转归有关,可作为评估患者病情及预后的重要指标。
Objective: To discuss the relationship between urinary protein quantification and serum visfatin(VF), homocysteine(HCY) in patients with primary glomerulonephritis(PGN). Methods: 100 patients with PGN were selected as PGN group. According to the treatment outcome, the patients were divided into good prognosis group(75 cases) and poor prognosis group(25 cases). Thirty health volunteers serve as healthy group. The serum levels of VF and HCY were determined by enzyme-linked immunosorbent assay, and 24 h urine samples were taken for quantitative determination of 24 h urinary protein. The relationship between 24 h urine protein quantification and serum VF and HCY levels was analyzed. Results: The 24 h urine protein, and serum VF and HCY levels in PGN group were significantly higher than those in healthy group, and those in good prognosis group were significantly lower than those in poor prognosis group(all P<0.05). Pearson correlation analysis showed that the 24 h urinary protein quantification was positively correlated with serum VF and HCY levels(r_1=0.687, P<0.05; r_2=0.695, P<0.05). Conclusions: Serum VF and HCY levels may be related to the occurrence and prognosis of PGN, and the detection of these indicators may be an important indicator for evaluating the patient's condition and prognosis.
Objective: To discuss the relationship between urinary protein quantification and serum visfatin(VF), homocysteine(HCY) in patients with primary glomerulonephritis(PGN). Methods: 100 patients with PGN were selected as PGN group. According to the treatment outcome, the patients were divided into good prognosis group(75 cases) and poor prognosis group(25 cases). Thirty health volunteers serve as healthy group. The serum levels of VF and HCY were determined by enzyme-linked immunosorbent assay, and 24 h urine samples were taken for quantitative determination of 24 h urinary protein. The relationship between 24 h urine protein quantification and serum VF and HCY levels was analyzed. Results: The 24 h urine protein, and serum VF and HCY levels in PGN group were significantly higher than those in healthy group, and those in good prognosis group were significantly lower than those in poor prognosis group(all P<0.05). Pearson correlation analysis showed that the 24 h urinary protein quantification was positively correlated with serum VF and HCY levels(r_1=0.687, P<0.05; r_2=0.695, P<0.05). Conclusions: Serum VF and HCY levels may be related to the occurrence and prognosis of PGN, and the detection of these indicators may be an important indicator for evaluating the patient's condition and prognosis.
引文
1 Esch KJ,Schaut RG,Lamb IM,et al.Activation of autophagy and nucleotide-binding domain leucine-rich repeat-containing-like receptor family,pyrin domain-containing 3 inflammasome during Leishmania infantum-associated glomerulonephritis[J].Am J Pathol,2015,185(8):2105-2117.
2 Muso E,Endo T,Itabashi M,et al.Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts[J].Clin Exp Nephrol,2013,17(5):659-662.
3 海燕,郑法雷,刘玉春,等.原发性肾小球疾病分型与治疗及疗效标准专题座谈会纪要[J].中华内科杂志,1993,32(2) :131-131.
4 王慧慧,闫晓光,马佳妮,等.新诊断2型糖尿病合并非酒精性脂肪肝患者血浆内脂素及视黄醇结合蛋白4的表达水平及其与胰岛素抵抗的关系[J].中国医药导报,2015,12(33):98-101.
5 Olszanecka-Glinianowicz M,Owczarek A,BoZentowicz-Wikarek M,et al.Relationship between circulating visfatin/NAMPT,nutritional status and insulin resistance in an elderly population - results from the PolSenior substudy[J].Metabolism,2014,63 (11):1409-1418.
6 崔国利,周奎臣,刘丽秋,等.糖尿病肾病患者血清内脂素、脂蛋白-α和同型半胱氨酸的相关性研究[J].中国生化药物杂志,2016,36(6):182-184.
7 罗凯,汪贤聪,张继成,等.维持性血液透析患者血同型半胱氨酸水平与营养不良及心血管结构与功能的关系[J].内科急危重症杂志,2017,23(2):121-123.
8 胡娟,周彦,王茁.慢性肾炎患者血清Hcy、APN、BNP水平的变化及临床意义[J].标记免疫分析与临床,2015,22(8):747-748.
9 Sabio JM,Vargas-Hitos JA,Martinez-Bordonado J,et al.Relationship between homocysteine levels and hypertension in systemic lupus erythematosus[J].Arthritis Care Res(Hoboken),2014,66(10):1528-1535.
2 Muso E,Endo T,Itabashi M,et al.Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts[J].Clin Exp Nephrol,2013,17(5):659-662.
3 海燕,郑法雷,刘玉春,等.原发性肾小球疾病分型与治疗及疗效标准专题座谈会纪要[J].中华内科杂志,1993,32(2) :131-131.
4 王慧慧,闫晓光,马佳妮,等.新诊断2型糖尿病合并非酒精性脂肪肝患者血浆内脂素及视黄醇结合蛋白4的表达水平及其与胰岛素抵抗的关系[J].中国医药导报,2015,12(33):98-101.
5 Olszanecka-Glinianowicz M,Owczarek A,BoZentowicz-Wikarek M,et al.Relationship between circulating visfatin/NAMPT,nutritional status and insulin resistance in an elderly population - results from the PolSenior substudy[J].Metabolism,2014,63 (11):1409-1418.
6 崔国利,周奎臣,刘丽秋,等.糖尿病肾病患者血清内脂素、脂蛋白-α和同型半胱氨酸的相关性研究[J].中国生化药物杂志,2016,36(6):182-184.
7 罗凯,汪贤聪,张继成,等.维持性血液透析患者血同型半胱氨酸水平与营养不良及心血管结构与功能的关系[J].内科急危重症杂志,2017,23(2):121-123.
8 胡娟,周彦,王茁.慢性肾炎患者血清Hcy、APN、BNP水平的变化及临床意义[J].标记免疫分析与临床,2015,22(8):747-748.
9 Sabio JM,Vargas-Hitos JA,Martinez-Bordonado J,et al.Relationship between homocysteine levels and hypertension in systemic lupus erythematosus[J].Arthritis Care Res(Hoboken),2014,66(10):1528-1535.