层层自组装多糖微胶囊的制备及其缓释型纯棉织物修饰应用
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摘要
为制备生物相容性功能纺织材料,采用层层自组装技术将带有不同电荷的海藻酸钠(Alg)、壳聚糖(Chi)、透明质酸(HA)组装到碳酸钙模板上,利用乙二胺四乙酸(EDTA)去除模板,得到Alg/Chi/HA生物多糖微胶囊;利用超景深三维显微镜、扫描电子显微镜、红外光谱、综合热分析仪研究了微胶囊的形貌结构及热稳定性。结果表明:Alg/Chi/HA多糖微胶囊具有很好的中空结构及较强的稳定性;考察了多糖微胶囊吸附释放行为及其随pH值的变化规律,发现Alg/Chi/HA多糖微胶囊具有良好的pH值响应性;进一步将Alg/Chi/HA多糖微胶囊整理至棉纤维上,以制备缓释型功能纺织材料,为功能纺织品开发提供有益的实践经验与技术储备。
The oppositely charged sodium alginate(Alg), chitosan(Chi), hyaluronic acid(HA) were coated onto the CaCO_3 template via layer-by-layer(LBL) self-assembled technique. The template was removed by using ethylenediaminetetraacetic acid(EDTA) to obtain hollow Alg/Chi/HA microcapsules. The purpose is to prepare biosafety functional fabrics.The morphology and thermal stability of microcapsules were studied by optical microscope with a large-depth-of-field, scanning electron microscope, infrared spectroscopy and comprehensive thermal analyzer. The results show that Alg/Chi/HA microcapsules have good hollow structure and strong stability. The pH-stimuli release behavior of microcapsules were investigated. These Alg/Chi/HA microcapsules were finished in the cotton fiber to manufacture the sustained releasing textile. This work is beneficial for the development of functional fabrics.
The oppositely charged sodium alginate(Alg), chitosan(Chi), hyaluronic acid(HA) were coated onto the CaCO_3 template via layer-by-layer(LBL) self-assembled technique. The template was removed by using ethylenediaminetetraacetic acid(EDTA) to obtain hollow Alg/Chi/HA microcapsules. The purpose is to prepare biosafety functional fabrics.The morphology and thermal stability of microcapsules were studied by optical microscope with a large-depth-of-field, scanning electron microscope, infrared spectroscopy and comprehensive thermal analyzer. The results show that Alg/Chi/HA microcapsules have good hollow structure and strong stability. The pH-stimuli release behavior of microcapsules were investigated. These Alg/Chi/HA microcapsules were finished in the cotton fiber to manufacture the sustained releasing textile. This work is beneficial for the development of functional fabrics.
引文
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[9] CA?IBANO-HERNáNDEZ A, SAENZ DEL BURGO L, ESPONA-NOGUERA A, et al. Alginate microcapsules incorporating hyaluronic acid recreate closerin vivo environment for mesenchymal stem cells[J]. Molecular Pharmaceutics, 2017, 14(7): 2390-2399.
[10] 杨晨辰. 基于透明质酸的刺激响应纳米凝胶的构建及其靶向药物传输治疗方面的应用研究[D]. 南京: 南京大学, 2016: 17-20.YANG Chenchen. Study on the preparation of stimuli-responsive nanogels based on hyaluronic acid and its application in targeting drug delivery[D]. Nanjing: Nanjing University, 2016: 17-20.
[11] DETEMMERMAN M, DEMEESTER J, DEVOS F, et al. Encapsulation performance of layer-by-layer microcapsules for proteins[J]. Biomacromolecules, 2011, 12(4): 1283-1289.
[2] 张维, 李秋瑾, 张健飞. 层层组装微胶囊的制备及其缓释性能[J]. 纺织学报, 2015, 36(3): 58-62.ZHANG Wei, LI Qiujin, ZHANG Jianfei. Preparation and controlled release of microcapsules via layer-by-layer assembly[J]. Journal of Textile Research, 2015, 36(3): 58-62.
[3] 冯建国, 杨关天, 袁小勇, 等. 高效氯氰菊酯微胶囊的制备、表征及释放性能[J]. 高等学校化学学报, 2017, 38(11): 1974-1981.FENG Jianguo, YANG Guantian, YUAN Xiaoyong, et al. Preparation, characterization and release properties of β-cypermethrin microcapsules[J]. Chemical Journal of Chinese Universties, 2017, 38(11): 1974-1981.
[4] 杨辉, 李通, 仝维鋆, 等. 基于碳酸钙模板的特殊形状层层组装微胶囊的制备[J]. 高等学校化学学报, 2018, 39(1): 172-177.YANG Hui, LI Tong, TONG Weijun, et al. Fabrication of microcapsules with special shapes by layer-by-layer assembly on CaCO3 microparticles[J]. Chemical Journal of Chinese Universities, 2018, 39(1): 172-177.
[5] COOK M T, TZORTZIS G, CHARALAMPOPOULOS D, et al. Production and evaluation of dry alginate-chitosan microcapsules as an enteric delivery vehicle for probiotic bacteria[J]. Biomacromolecules, 2011, 12(7): 2834-2840.
[6] DENG L, LI Q, AL-REHILI S A, et al. Hybrid iron oxide-graphene oxide-polysaccharides microcapsule: a micro-matryoshka for on-demand drug release and antitumor therapy in vivo[J]. ACS Applied Materials & Interfaces, 2016, 8(11): 6859-6868.
[7] TAHTAT D, MAHLOUS M, BENAMER S, et al. Oral delivery of insulin from alginate/chitosan crosslinked by glutaraldehyde[J]. International Journal of Biological Macromolecules, 2013, 58: 160-168.
[8] 王亚, 黄菁菁, 张如全. 艾蒿油-壳聚糖抗菌微胶囊的制备及其应用[J]. 纺织学报, 2018, 39(10): 99-103.WANG Ya, HUANG Jingjing, ZHANG Ruquan. Preparation and application of antimicrobial mug wort oil-chitosan microcapsules[J]. Journal of Textile Research, 2018, 39(10): 99-103.
[9] CA?IBANO-HERNáNDEZ A, SAENZ DEL BURGO L, ESPONA-NOGUERA A, et al. Alginate microcapsules incorporating hyaluronic acid recreate closerin vivo environment for mesenchymal stem cells[J]. Molecular Pharmaceutics, 2017, 14(7): 2390-2399.
[10] 杨晨辰. 基于透明质酸的刺激响应纳米凝胶的构建及其靶向药物传输治疗方面的应用研究[D]. 南京: 南京大学, 2016: 17-20.YANG Chenchen. Study on the preparation of stimuli-responsive nanogels based on hyaluronic acid and its application in targeting drug delivery[D]. Nanjing: Nanjing University, 2016: 17-20.
[11] DETEMMERMAN M, DEMEESTER J, DEVOS F, et al. Encapsulation performance of layer-by-layer microcapsules for proteins[J]. Biomacromolecules, 2011, 12(4): 1283-1289.