槟榔的化学成分和药理活性研究进展
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摘要
槟榔作为一味传统中药广泛分布于我国南部热带、亚热带地区以及其他南亚、东南亚等国家。槟榔果既是一种目前被广泛食用的佳果,其果皮和种子又可以入药,是我国名贵的"四大南药"之一。现代研究表明槟榔含有生物碱、鞣质、黄酮、萜类等多种化学成分,具有促消化、降血压、抗抑郁、抗氧化、抗炎、抗寄生虫和抑菌等活性。综述了近年来槟榔化学成分及药理活性研究进展,为槟榔传统产品的食用安全及其产品研发提供研究基础。
Areca catechu is a traditional Chinese medicine and an important medicine and food homologous variety, it's widely distributed in tropical and subtropical provinces in southern China and other countries in South Asia and Southeast Asia. The fruitage of A. catechu is not only a kind of great fruit widely eaten to welcome guests, but also its peels and seeds can be used as medicines. Arecae Semen is one of the four precious "Southern Medicine" in China. Modern studies have shown that A. catechu contains alkaloids,tannins, flavonoids, terpenoids and other chemical constituents. It has multiple activities in promoting digestion, lowering blood pressure and anti-depressant, anti-oxidation, anti-inflammatory, anti-parasitic and bacteriostatic activities etc. In this paper, the research progress of chemical constituents and pharmacological activities of A. catechu in recent years was summarized, which provided research basis for the edible safety, research and development of traditional Areca products.
Areca catechu is a traditional Chinese medicine and an important medicine and food homologous variety, it's widely distributed in tropical and subtropical provinces in southern China and other countries in South Asia and Southeast Asia. The fruitage of A. catechu is not only a kind of great fruit widely eaten to welcome guests, but also its peels and seeds can be used as medicines. Arecae Semen is one of the four precious "Southern Medicine" in China. Modern studies have shown that A. catechu contains alkaloids,tannins, flavonoids, terpenoids and other chemical constituents. It has multiple activities in promoting digestion, lowering blood pressure and anti-depressant, anti-oxidation, anti-inflammatory, anti-parasitic and bacteriostatic activities etc. In this paper, the research progress of chemical constituents and pharmacological activities of A. catechu in recent years was summarized, which provided research basis for the edible safety, research and development of traditional Areca products.
引文
[1]中国药典[S].一部.2015.
[2]Gupta P C,Warnakulasuriya S.Global epidemiology of areca nut usage[J].Add Biol,2010,7(1):77-83.
[3]贾哲,韩婷,刘欢,等.基于多元统计分析的食用槟榔及药用槟榔主要化学成分的含量对比研究[J].中华中医药杂志,2017,32(11):5158-5161.
[4]Mehrtash H,Duncan K,Parascandola M,et al.Defining a global research and policy agenda for betel quid and areca nut[J].Lancet Oncol,2017,18(12):e767-e775.
[5]Holdsworth D K,Jones R A,Self R.Volatile alkaloids from Areca catechu[J].Phytochemistry,1998,48(3):581-582.
[6]Wei P,Yu J L,Chong B Z,et al.In silico assessment of drug-like properties of alkaloids from Areca catechu L.nut[J].Tropical J Pharm Res,2015,14(4):635-639.
[7]Tang S N,Zhang J,Liu D,et al.Three new areca alkaloids from the nuts of Areca catechu[J].J Asian Nat Prod Res,2017,19(12):1155-1159.
[8]牟肖男,杨文强,王文婧,等.槟榔的化学成分[J].暨南大学学报:自然科学与医学版,2014,35(1):56-60.
[9]张兴,梅文莉,曾艳波,等.槟榔果实的酚类化学成分与抗菌活性的初步研究[J].热带亚热带植物学报,2009,17(1):74-76.
[10]杨文强,王红程,王文婧,等.槟榔化学成分研究[J].中药材,2012,35(3):400-403.
[11]Ma Y,Feng L H,Lan S J,et al.Tannins from betel nuts[J].J Chin Chem Soc,2013,43(1):77-81.
[12]Saeed S A,Farnaz S,Simjee R U,et al.Triterpenes andβ-sitosterol from piper betle:Isolation,antiplatelet and anti-inflammatory effects[J].Biochem Soc Trans,1993,21(4):462S.
[13]何细新,李亚军,胡小鹏,等.槟榔壳中三萜及蒽醌类成分的分离与结构鉴定[J].中药新药与临床药理,2010,21(6):634-636.
[14]Yenjit P,Issarakraisila M,Intana W,et al.Fungicidal activity of compounds extracted from the pericarp of Areca catechu,against Colletotrichum gloeosporioides in vitro,and in mango fruit[J].Postharv Biol Technol,2010,55(2):129-132.
[15]周文化,李忠海,张海德,等.槟榔果仁油提取及其脂肪酸分析[J].中国粮油学报,2010,25(8):38-41.
[16]胡延喜,徐亮,王志萍,等.槟榔果皮挥发油成分的GC-MS分析[J].时珍国医国药,2017,28(5):1055-1056.
[17]肖培根.新编中药志(第2卷)[M].北京:化学工业出版社,2002.
[18]曾琪.槟榔化学成分的研究[D].长沙:中南林业科技大学,2007.
[19]Xing Z,Jiao W U,Zhuang H.Antioxidant and cytotoxic phenolic compounds of Areca nut(Areca catechu)[J].Chem Res Chin Univ,2010,26(1):161-164.
[20]张兴,梅文莉,戴好富.槟榔果实化学成分研究[A]//中国药学会学术年会论文集[C].石家庄:中国药学会,2008.
[21]李晨,范尧夫,吕涛,等.槟榔有效组分的提取分离及其对大鼠胃平滑肌收缩作用影响的研究[J].中医学报,2013,28(5):683-685.
[22]郭喜军.槟榔对大鼠胃运动及神经递质的影响[J].中国中西医结合消化杂志,2009,17(5):300-303.
[23]Mateusz P K,Katarzyna B,Karolina A K,et al.Risks associated with betel quid chewing[J].Curr Issues Pharm Med Sci,2017,30(1):24-26.
[24]肖冰梅,肖嫩群,彭买姣,等.槟榔碱提神效果及急性毒性作用研究[J].中国当代医药,2013,20(20):14-16.
[25]孙艳萍,韩容,罗娟,等.槟榔碱对小鼠酒精急性中枢抑制作用的影响[J].中国药物依赖性杂志,2005,14(5):333-337.
[26]何嘉泳,黄保,辛志添,等.槟榔种子总酚类抗抑郁作用研究[J].中药材,2013,36(8):1331-1334.
[27]Jiang J M,Wang L,Gu H F,et al.Arecoline induces neurotoxicity to PC12 cells:Involvement in ER stress and disturbance of endogenous H2S generation[J].Neurochem Res,2016,41(8):1-9.
[28]Inokuchi J I,Okabe H,Yamauchi T,et al.Antihypertensive substance in seeds of Areca catechu L.[J].Life Sci,1986,38(15):1375-1382.
[29]Anwarul H G,Muhammad N G,Peter J H,et al.Studies on the hypotensive,cardio-suppressant,vasodilator and antiplatelet activities of betel nut crude extract and its constituents[J].Int J Pharmacol,2006,2(1):33-41.
[30]陈洪,罗光远,陈夏雨,等.槟榔中槟榔碱的药理研究进展[J].桂林师范高等专科学校学报,2017,31(2):116-120.
[31]Calogero A E,Kamilaris T C,Gomez M T,et al.The muscarinic cholinergic agonist arecoline stimulates the rat hypothalamic-pituitary-adrenal axis through a centrallymediated corticotropin-releasing hormone-dependent mechanism[J].Endocrinology,1989,125(5):2445-2453.
[32]Lim D Y,Kim I S.Arecoline inhibits catecholamine release from perfused rat adrenal gland[J].Acta Pharmacol Sin,2010,27(1):71-79.
[33]Dasgupta R,Chatterjee A,Sarkar S,et al.Arecoline aggravates hypothyroidism in metabolic stress in mice[J].Archiv Physiol Biochem,2017,123(2):105-111.
[34]Dasgupta R,Saha I,Maity A,et al.Arecoline ameliorates hyperthyroid condition in mice under cold stress[J].Archiv Physiol Biochem,2018,124(5):436-441.
[35]Huang P L,Chi C W,Liu T Y.Effects of Areca catechu L.containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo[J].Food Chem Toxicol,2010,48(1):306-313.
[36]Khan S,Mehmood M H,Ali A N,et al.Studies on anti-inflammatory and analgesic activities of betel nut in rodents[J].J Ethnopharmacol,2011,135(3):654-661.
[37]Lee J H,Chang S H,Park Y S,et al.In vitro and in vivo anti-allergic actions of Arecae Semen[J].J Pharm Pharmacol,2010,56(7):927-933.
[38]Wang C C,Lin Y R,Liao M H,et al.Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice[J].Bmc Compl Alternat Med,2013,doi:10.1186/1472-6882-13-154.
[39]Papke R L,Horenstein N A,Clare S.Nicotinic activity of arecoline,the psychoactive element of“betel nuts”,suggests a basis for habitual use and anti-inflammatory activity[J].PLoS One,2015,10(10):1-8.
[40]罗士数,张海德,刘小玲,等.槟榔中槟榔碱体外抑菌活性的研究[J].农产品加工:创新版,2010,(9):47-50.
[41]李韦,王定发,周璐丽,等.槟榔驱虫作用的研究进展[J].养殖与饲料,2015(2):6-9.
[42]李桂玲,冯青,杨盈,等.槟榔果中灭钉螺增效成分的研究[J].中国中药杂志,2000,25(3):160-162.
[43]张丹.槟榔提取物不同部位的抗氧化性比较及成分研究[J].食品工业科技,2015,36(2):102-104.
[44]张璐,郑亚军,李艳,等.槟榔籽乙醇提取物抗氧化性的研究[J].食品研究与开发,2016,37(8):1-4.
[45]唐敏敏.槟榔多糖的抗氧化活性及其对细胞内氧化损伤抑制作用的研究[J].热带作物学报,2015,36(6):1136-1141.
[46]Prabhu R V,Prabhu V,Chatra L,et al.Areca nut and its role in oral submucous fibrosis[J].J Clin Experim Dent,2014,6(5):e569-575.
[47]Lin Q H,Jia Z,Xu X F,et al.Sub-chronic toxicity study of arecae semen aqueous extract in Wistar rats[J].JEthnopharmacol,2017,doi:10.1016/j.jep.2017.08.031.
[48]吕俊辰,弓宝,孙佩文.槟榔药用和食用安全性研究概况[J].中草药,2017,48(2):384-390.
[49]Liu S T,Young G C,Lee Y C,et al.A preliminary report on the toxicity of arecoline on early pregnancy in mice[J].Food Chem Toxicol,2011,49(1):144-148.
[50]韩容,孙艳萍,李俊旭,等.槟榔碱对小鼠吗啡行为敏化的影响[J].中国药物依赖性杂志,2005,14(3):197-202.
[2]Gupta P C,Warnakulasuriya S.Global epidemiology of areca nut usage[J].Add Biol,2010,7(1):77-83.
[3]贾哲,韩婷,刘欢,等.基于多元统计分析的食用槟榔及药用槟榔主要化学成分的含量对比研究[J].中华中医药杂志,2017,32(11):5158-5161.
[4]Mehrtash H,Duncan K,Parascandola M,et al.Defining a global research and policy agenda for betel quid and areca nut[J].Lancet Oncol,2017,18(12):e767-e775.
[5]Holdsworth D K,Jones R A,Self R.Volatile alkaloids from Areca catechu[J].Phytochemistry,1998,48(3):581-582.
[6]Wei P,Yu J L,Chong B Z,et al.In silico assessment of drug-like properties of alkaloids from Areca catechu L.nut[J].Tropical J Pharm Res,2015,14(4):635-639.
[7]Tang S N,Zhang J,Liu D,et al.Three new areca alkaloids from the nuts of Areca catechu[J].J Asian Nat Prod Res,2017,19(12):1155-1159.
[8]牟肖男,杨文强,王文婧,等.槟榔的化学成分[J].暨南大学学报:自然科学与医学版,2014,35(1):56-60.
[9]张兴,梅文莉,曾艳波,等.槟榔果实的酚类化学成分与抗菌活性的初步研究[J].热带亚热带植物学报,2009,17(1):74-76.
[10]杨文强,王红程,王文婧,等.槟榔化学成分研究[J].中药材,2012,35(3):400-403.
[11]Ma Y,Feng L H,Lan S J,et al.Tannins from betel nuts[J].J Chin Chem Soc,2013,43(1):77-81.
[12]Saeed S A,Farnaz S,Simjee R U,et al.Triterpenes andβ-sitosterol from piper betle:Isolation,antiplatelet and anti-inflammatory effects[J].Biochem Soc Trans,1993,21(4):462S.
[13]何细新,李亚军,胡小鹏,等.槟榔壳中三萜及蒽醌类成分的分离与结构鉴定[J].中药新药与临床药理,2010,21(6):634-636.
[14]Yenjit P,Issarakraisila M,Intana W,et al.Fungicidal activity of compounds extracted from the pericarp of Areca catechu,against Colletotrichum gloeosporioides in vitro,and in mango fruit[J].Postharv Biol Technol,2010,55(2):129-132.
[15]周文化,李忠海,张海德,等.槟榔果仁油提取及其脂肪酸分析[J].中国粮油学报,2010,25(8):38-41.
[16]胡延喜,徐亮,王志萍,等.槟榔果皮挥发油成分的GC-MS分析[J].时珍国医国药,2017,28(5):1055-1056.
[17]肖培根.新编中药志(第2卷)[M].北京:化学工业出版社,2002.
[18]曾琪.槟榔化学成分的研究[D].长沙:中南林业科技大学,2007.
[19]Xing Z,Jiao W U,Zhuang H.Antioxidant and cytotoxic phenolic compounds of Areca nut(Areca catechu)[J].Chem Res Chin Univ,2010,26(1):161-164.
[20]张兴,梅文莉,戴好富.槟榔果实化学成分研究[A]//中国药学会学术年会论文集[C].石家庄:中国药学会,2008.
[21]李晨,范尧夫,吕涛,等.槟榔有效组分的提取分离及其对大鼠胃平滑肌收缩作用影响的研究[J].中医学报,2013,28(5):683-685.
[22]郭喜军.槟榔对大鼠胃运动及神经递质的影响[J].中国中西医结合消化杂志,2009,17(5):300-303.
[23]Mateusz P K,Katarzyna B,Karolina A K,et al.Risks associated with betel quid chewing[J].Curr Issues Pharm Med Sci,2017,30(1):24-26.
[24]肖冰梅,肖嫩群,彭买姣,等.槟榔碱提神效果及急性毒性作用研究[J].中国当代医药,2013,20(20):14-16.
[25]孙艳萍,韩容,罗娟,等.槟榔碱对小鼠酒精急性中枢抑制作用的影响[J].中国药物依赖性杂志,2005,14(5):333-337.
[26]何嘉泳,黄保,辛志添,等.槟榔种子总酚类抗抑郁作用研究[J].中药材,2013,36(8):1331-1334.
[27]Jiang J M,Wang L,Gu H F,et al.Arecoline induces neurotoxicity to PC12 cells:Involvement in ER stress and disturbance of endogenous H2S generation[J].Neurochem Res,2016,41(8):1-9.
[28]Inokuchi J I,Okabe H,Yamauchi T,et al.Antihypertensive substance in seeds of Areca catechu L.[J].Life Sci,1986,38(15):1375-1382.
[29]Anwarul H G,Muhammad N G,Peter J H,et al.Studies on the hypotensive,cardio-suppressant,vasodilator and antiplatelet activities of betel nut crude extract and its constituents[J].Int J Pharmacol,2006,2(1):33-41.
[30]陈洪,罗光远,陈夏雨,等.槟榔中槟榔碱的药理研究进展[J].桂林师范高等专科学校学报,2017,31(2):116-120.
[31]Calogero A E,Kamilaris T C,Gomez M T,et al.The muscarinic cholinergic agonist arecoline stimulates the rat hypothalamic-pituitary-adrenal axis through a centrallymediated corticotropin-releasing hormone-dependent mechanism[J].Endocrinology,1989,125(5):2445-2453.
[32]Lim D Y,Kim I S.Arecoline inhibits catecholamine release from perfused rat adrenal gland[J].Acta Pharmacol Sin,2010,27(1):71-79.
[33]Dasgupta R,Chatterjee A,Sarkar S,et al.Arecoline aggravates hypothyroidism in metabolic stress in mice[J].Archiv Physiol Biochem,2017,123(2):105-111.
[34]Dasgupta R,Saha I,Maity A,et al.Arecoline ameliorates hyperthyroid condition in mice under cold stress[J].Archiv Physiol Biochem,2018,124(5):436-441.
[35]Huang P L,Chi C W,Liu T Y.Effects of Areca catechu L.containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo[J].Food Chem Toxicol,2010,48(1):306-313.
[36]Khan S,Mehmood M H,Ali A N,et al.Studies on anti-inflammatory and analgesic activities of betel nut in rodents[J].J Ethnopharmacol,2011,135(3):654-661.
[37]Lee J H,Chang S H,Park Y S,et al.In vitro and in vivo anti-allergic actions of Arecae Semen[J].J Pharm Pharmacol,2010,56(7):927-933.
[38]Wang C C,Lin Y R,Liao M H,et al.Oral supplementation with areca-derived polyphenols attenuates food allergic responses in ovalbumin-sensitized mice[J].Bmc Compl Alternat Med,2013,doi:10.1186/1472-6882-13-154.
[39]Papke R L,Horenstein N A,Clare S.Nicotinic activity of arecoline,the psychoactive element of“betel nuts”,suggests a basis for habitual use and anti-inflammatory activity[J].PLoS One,2015,10(10):1-8.
[40]罗士数,张海德,刘小玲,等.槟榔中槟榔碱体外抑菌活性的研究[J].农产品加工:创新版,2010,(9):47-50.
[41]李韦,王定发,周璐丽,等.槟榔驱虫作用的研究进展[J].养殖与饲料,2015(2):6-9.
[42]李桂玲,冯青,杨盈,等.槟榔果中灭钉螺增效成分的研究[J].中国中药杂志,2000,25(3):160-162.
[43]张丹.槟榔提取物不同部位的抗氧化性比较及成分研究[J].食品工业科技,2015,36(2):102-104.
[44]张璐,郑亚军,李艳,等.槟榔籽乙醇提取物抗氧化性的研究[J].食品研究与开发,2016,37(8):1-4.
[45]唐敏敏.槟榔多糖的抗氧化活性及其对细胞内氧化损伤抑制作用的研究[J].热带作物学报,2015,36(6):1136-1141.
[46]Prabhu R V,Prabhu V,Chatra L,et al.Areca nut and its role in oral submucous fibrosis[J].J Clin Experim Dent,2014,6(5):e569-575.
[47]Lin Q H,Jia Z,Xu X F,et al.Sub-chronic toxicity study of arecae semen aqueous extract in Wistar rats[J].JEthnopharmacol,2017,doi:10.1016/j.jep.2017.08.031.
[48]吕俊辰,弓宝,孙佩文.槟榔药用和食用安全性研究概况[J].中草药,2017,48(2):384-390.
[49]Liu S T,Young G C,Lee Y C,et al.A preliminary report on the toxicity of arecoline on early pregnancy in mice[J].Food Chem Toxicol,2011,49(1):144-148.
[50]韩容,孙艳萍,李俊旭,等.槟榔碱对小鼠吗啡行为敏化的影响[J].中国药物依赖性杂志,2005,14(3):197-202.