复元活血汤加减治疗对脊柱骨折患者术后炎性因子、凝血功能及疼痛程度的影响
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摘要
目的:分析脊柱骨折患者采用复元活血汤加减治疗的临床疗效以及对患者疼痛程度、凝血功能与术后炎症因子产生的影响。方法:于我院2014年12月-2017年12月收治的脊柱骨折患者中选取80例,随机分为两组,对照组行常规治疗,观察组在对照组基础上采用复元活血汤治疗,对比两组治疗前后视觉模拟疼痛(VAS)评分、D-二聚体含量(D-D)、纤维蛋白原(FIB)、血小板计数(PLT)等凝血功能指标与高迁移率族蛋白1(HMGB1)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、反应蛋白(CRPC)等血清炎性因子水平变化情况。结果:观察组治疗后第3 d的VAS评分、D-D、FIB、PLT等凝血功能指标水平与HMGB1、PCT、TNF-α、CRP等血清炎性因子水平均低于对照组,组间差异有统计学意义,P <0.05。结论:脊柱骨折患者采用复元活血汤加减治疗的临床疗效显著,有利于减轻患者疼痛程度,改善术后凝血功能与机体炎症状态,值得推广。
Objective: To analyze clinical efficacy of the Fuyuan Huoxue decoction(复元活血汤) on inflammatory factors, coagulation function and pain level in patients with spinal fracture after surgery. Methods: December 2014-December 2017, 80 cases were divided into 2 groups. The control group was given conventional treatment; and the observation group was given the Fuyuan Huoxue decoction more.Results: After treatment, the VAS score, D-D, FIB, PLT, etc. and HMGB1, PCT, TNF-α, CRP and other levels in the observation group were lower than the control group, P<0.05. Conclusion: The Fuyuan Huoxue decoction on inflammatory factors, coagulation function and pain level in patients with spinal fracture after surgery show a good effect, can alleviate the pain level of patients and improve the postoperative coagulation function and the inflammatory state of the body, which is worth promoting.
Objective: To analyze clinical efficacy of the Fuyuan Huoxue decoction(复元活血汤) on inflammatory factors, coagulation function and pain level in patients with spinal fracture after surgery. Methods: December 2014-December 2017, 80 cases were divided into 2 groups. The control group was given conventional treatment; and the observation group was given the Fuyuan Huoxue decoction more.Results: After treatment, the VAS score, D-D, FIB, PLT, etc. and HMGB1, PCT, TNF-α, CRP and other levels in the observation group were lower than the control group, P<0.05. Conclusion: The Fuyuan Huoxue decoction on inflammatory factors, coagulation function and pain level in patients with spinal fracture after surgery show a good effect, can alleviate the pain level of patients and improve the postoperative coagulation function and the inflammatory state of the body, which is worth promoting.
引文
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[10]王阳,宋洁富.中西医结合治疗骨质疏松性椎体压缩骨折临床观察[J].中医临床研究,2015,7(10):22-24.
[2]苗海震,肖毅.骨伤复原汤对胸腰椎骨折术后患者血清炎症因子、纤维蛋白原及疼痛程度的影响[J].中医学报,2017,32(05):848-851.
[3]刘维统,杨景帆.康复训练与舒筋活血洗剂联用对踝关节骨折术后关节功能恢复及炎性因子的影响[J].世界中医药,2017,12(06):1320-1323.
[4]谢伟,郑建平,吴向科,等.复元活血汤对脊柱骨折术后腹胀、便秘的临床疗效观察[J].中华中医药学刊,2014,24(02):438-440.
[5]黄善武,欧阳永生.前路与后路内固定治疗成人胸腰段脊柱骨折疗效观察[J].现代中西医结合杂志,2014,23(10):1104-1105.
[6]汪礼军,杨秀江,胡侦明,等.陈旧性不稳定型骨质疏松脊柱骨折PVP治疗疗效观察[J].重庆医学,2017,46(09):1208-1210.
[7]张国华,杜伟,罗鹏明,等.微创手术与传统开放手术在胸腰段脊柱骨折治疗中的应用效果[J].现代生物医学进展,2017,17(07):1286-1289.
[8]熊其林.中医正骨治疗桡骨远端骨折疗效及相关因素研究[J].中医临床研究,2014,6(21):115-117.
[9]胡向阳,李小芳.壮骨汤治疗老年性骨质疏松脊柱压缩性骨折临床研究[J].中医临床研究,2014,6(05):163-164.
[10]王阳,宋洁富.中西医结合治疗骨质疏松性椎体压缩骨折临床观察[J].中医临床研究,2015,7(10):22-24.