基于变异系数的模糊物元模型评价不同产地大黄药材质量
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摘要
目的利用基于变异系数的模糊物元模型评价不同产地大黄的质量。方法结合欧氏贴近度概念,构建基于变异系数权重的中药质量综合评价的模糊物元模型。选取大黄中没食子酸、游离蒽醌等14个评价指标,评价不同产地大黄的质量。结果 27个产地大黄药材样品中,欧氏贴近度ρH_j>0.2209的样品有9批,主要集中在四川和甘肃陇南,品质较优,均具有"红肉白筋,体重质坚,星点环列,味苦"的优良性状特征;ρH_j<0.160 4的样品主要集中在青海达日和四川峨眉山等地,样品性状与"个头普遍较小,体轻质松,内部有糠心"的劣药特征一致。结论本研究建立的模型使用简单、易于计算,能客观反映大黄药材的质量,也可为基于多种化学成分指标的其他中药材质量综合评价提供参考。
Objective To evaluate the quality of Rhei Radix et Rhizoma from different producing areas through fuzzy matter-element model based on coefficient of variation. Methods Combined with the concept of Euclidean closeness degree, a fuzzy matter-element model based on variation coefficient weight for comprehensive evaluation of quality of TCM was established. 14 evaluation indexes including gallic acid and free anthraquinones were chosen to evaluate quality of Rhei Radix et Rhizoma from different producing areas. Results Among samples from 27 producing areas, the Euclidean approximation value of 9 batches of samples ρH_j >0.220 9, which were mainly concentrated in Longnan of Gansu Province and Sichuan Province, and the quality of these samples was better, which had good characteristics such as "red meat, white gluten, strong body weight, star dots, and bitter taste"; ρH_j <0.160 4 samples were concentrated in Dari Qinghai and Emeishan Sichuan. The characteristics of the samples were consistent with those of inferior medicines with "generally small size, light weight, loose body and bran heart". Conclusion The model is simple and easy to calculate, which can objectively reflect the quality of Rhei Radix et Rhizoma and provide references for comprehensively evaluating the quality of other TCM based on various chemical constituents.
Objective To evaluate the quality of Rhei Radix et Rhizoma from different producing areas through fuzzy matter-element model based on coefficient of variation. Methods Combined with the concept of Euclidean closeness degree, a fuzzy matter-element model based on variation coefficient weight for comprehensive evaluation of quality of TCM was established. 14 evaluation indexes including gallic acid and free anthraquinones were chosen to evaluate quality of Rhei Radix et Rhizoma from different producing areas. Results Among samples from 27 producing areas, the Euclidean approximation value of 9 batches of samples ρH_j >0.220 9, which were mainly concentrated in Longnan of Gansu Province and Sichuan Province, and the quality of these samples was better, which had good characteristics such as "red meat, white gluten, strong body weight, star dots, and bitter taste"; ρH_j <0.160 4 samples were concentrated in Dari Qinghai and Emeishan Sichuan. The characteristics of the samples were consistent with those of inferior medicines with "generally small size, light weight, loose body and bran heart". Conclusion The model is simple and easy to calculate, which can objectively reflect the quality of Rhei Radix et Rhizoma and provide references for comprehensively evaluating the quality of other TCM based on various chemical constituents.
引文
[1]国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2015:23-24.
[2]李牧,杜智敏.芦荟大黄素的药理作用研究进展[J].中国临床药理学杂志,2015,31(9):765-768.
[3]童妍,金钊.大黄素甲醚的药理作用研究进展[J].中华中医药学刊,2015,33(4):938-940.
[4]庄江能.大黄的主要成分及其临床药理研究进展[J].西南军医,2009,11(5):931-933.
[5]窦志华,乔进,卞理,等.指纹图谱与一测多评法相结合的大黄质量控制方法[J].中国药学杂志,2015,50(5):442-448.
[6]汪琛媛.四味黄连洗剂制备工艺及质量标准研究[D].合肥:安徽中医药大学,2017.
[7]张依倩,王玉,张兰兰,等.大黄的质量评价方法研究进展与展望[J].中药材,2010,33(10):1663-1668.
[8]蔡文.可拓论及其应用[J].科学通报,1999,44(7):673-682.
[9]龚小红,赵梦杰,党珏,等.基于主成分分析不同产地大黄13个成分量的比较研究[J].中草药,2017,48(23):4994-4999.
[10]唐摇影,黄显峰,方国华.基于组合权重的模糊物元评价模型在丰县水质评价中的应用[J].水电能源科学,2014,32(6):37-41.
[11]王跃华,孙雁霞,徐文俊,等.不同产地大黄质量分析研究[J].成都大学学报:自然科学版,2007,26(3):177-179.
[12]张学儒.大黄药材商品规格评价与合理用药的研究[D].长沙:湖南中医药大学,2010.
[13]刘书斌,李成义,张樱山,等.基于变异系数权重的模糊物元模型评价甘肃商品纹党的质量[J].中国实验方剂学杂志,2016,22(9):16-20.
[14]米晓兰,韩红梅,王雪媛,等.基于变异系数权重法祁菊不同采收期有效成分含量研究[J].时珍国医国药,2018,29(4):990-993.
[2]李牧,杜智敏.芦荟大黄素的药理作用研究进展[J].中国临床药理学杂志,2015,31(9):765-768.
[3]童妍,金钊.大黄素甲醚的药理作用研究进展[J].中华中医药学刊,2015,33(4):938-940.
[4]庄江能.大黄的主要成分及其临床药理研究进展[J].西南军医,2009,11(5):931-933.
[5]窦志华,乔进,卞理,等.指纹图谱与一测多评法相结合的大黄质量控制方法[J].中国药学杂志,2015,50(5):442-448.
[6]汪琛媛.四味黄连洗剂制备工艺及质量标准研究[D].合肥:安徽中医药大学,2017.
[7]张依倩,王玉,张兰兰,等.大黄的质量评价方法研究进展与展望[J].中药材,2010,33(10):1663-1668.
[8]蔡文.可拓论及其应用[J].科学通报,1999,44(7):673-682.
[9]龚小红,赵梦杰,党珏,等.基于主成分分析不同产地大黄13个成分量的比较研究[J].中草药,2017,48(23):4994-4999.
[10]唐摇影,黄显峰,方国华.基于组合权重的模糊物元评价模型在丰县水质评价中的应用[J].水电能源科学,2014,32(6):37-41.
[11]王跃华,孙雁霞,徐文俊,等.不同产地大黄质量分析研究[J].成都大学学报:自然科学版,2007,26(3):177-179.
[12]张学儒.大黄药材商品规格评价与合理用药的研究[D].长沙:湖南中医药大学,2010.
[13]刘书斌,李成义,张樱山,等.基于变异系数权重的模糊物元模型评价甘肃商品纹党的质量[J].中国实验方剂学杂志,2016,22(9):16-20.
[14]米晓兰,韩红梅,王雪媛,等.基于变异系数权重法祁菊不同采收期有效成分含量研究[J].时珍国医国药,2018,29(4):990-993.