中医药治疗口腔黏膜下纤维化的临床研究进展
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摘要
口腔黏膜下纤维化主要以药物治疗,近年来中医药在治疗该病方面取得了较大的进展。本文从中医学角度解释口腔黏膜下纤维化的病因机理,然后分天然药物、中成药、方剂三类,总结近年中医药治疗该病的临床研究进展,为口腔黏膜下纤维化的临床用药提供参考。
Oral submucous fibrosis(OSF) mainly focuses on drug therapy. Traditional Chinese medicine has made a great progress in the treatment of the disease in recent years. This paper firstly explains the mechanism of OSF, and then summarizes the clinical research progress in recent years from natural medicines, proprietary Chinese medicine, and prescriptions, with aim to provide reference for clinical medication of OSF.
Oral submucous fibrosis(OSF) mainly focuses on drug therapy. Traditional Chinese medicine has made a great progress in the treatment of the disease in recent years. This paper firstly explains the mechanism of OSF, and then summarizes the clinical research progress in recent years from natural medicines, proprietary Chinese medicine, and prescriptions, with aim to provide reference for clinical medication of OSF.
引文
[1] Rajalalitha P,Vali S.Molecular pathogenesis of oral submucous fibrosis--a collagen metabolic disorder [J].J Oral Pathol Med,2005,34(6):321-328.
[2] 刘锦丽,陈方曼,江潞.口腔黏膜下纤维性变的药物治疗进展[J].国际口腔医学杂志,2017,44(3):325-331.
[3] 杨晨希,翦新春,潘英瑜,等.口腔黏膜下纤维性变治疗进展[J].海南医学,2017,28(20):3376-3378.
[4] Chole RH,Gondivkar SM,Gadbail AR,et al.Review of drug treatment of oral submucous fibrosis [J].Oral Oncol,2012,48(5):393-398.
[5] 张姗姗,凌天牖.口腔黏膜下纤维性变的治疗研究进展[J].口腔医学,2013,33(5):351-352.
[6] 谭劲,吴丹,刘寻,等.从虚瘀痰毒探讨口腔黏膜下纤维化的发病机制[J].湖南中医药大学学报,2016,36(3):38-39.
[7] Liu P,Liu CH,Wang HN,et al.Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells [J].Acta Phamacol Sin,2002,23(8):733-738.
[8] Lv Z,Xu L.Salvianolic acid B inhibits ERK and p38 MAPK Signaling in TGF-β1-stimulated human hapatic stellate cellline(LX-2) via distinct pathways [J].Evid Based Complement Alternat Med,2012,2012:1-11.
[9] Wang SX,Hu LM,Gao XM,et al.Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuro protective effect [J].Neurochem Res,2010,35(7):1029-1037.
[10] 翦新春,郑廉,朱蓉,等.曲安奈德和丹参酮注射液治疗口腔黏膜下纤维化的效果评价[J].中华口腔医学杂志,2017,52(1):16-21.
[11] 赵雁焕,徐梅,陆洋.丹参注射液联合曲安奈德局部注射治疗OSF的疗效及对血清TGF-β1、IL-6的影响[J].海南医学院学报,2017,23(5):673-679.
[12] 吴颖芳,彭解英,阙国鹰,等.中西医结合治疗口腔黏膜下纤维化的疗效[J].中南大学学报(医学版),2010,35(4):358-364.
[13] 张丽,龙卉,段开文.芦荟在口腔临床医学应用中的研究新进展[J].口腔医学,2017,37(3):285-288.
[14] Hamman JH.Composition and applications of Aloe vera leaf gel [J].Molecules,2008,13 (8):1599.
[15] Patil S,Halgatti V,Maheshwari S.Comparative study of the efficacy of herbal antioxdantsoxitard and aloe vera in the treatment of oral submucous fibrosis [J].J Clin Exp Dent,2014,6(3):e265-e270.
[16] Alam S,Ali I,Giri KY,et al.Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis [J].Oral Surg Oral Med Oral Pathol Oral Radiol,2013,116(6):717-724.
[17] Sudarshan R,Annigeri RG.Aloe vera in the treatment for oral submucous fibrosis apreliminary study [J].J Oral Pathol Med,2012,41(10):755-761.
[18] 左雯鑫,李晓宇,蔡淦英,等.复方丹参滴丸联合曲安奈德治疗口腔黏膜下纤维性变的临床研究[J].实用口腔医学杂志,2014,30(6):846-848.
[19] 谭劲,李元聪,陈安,等.丹玄口康治疗口腔黏膜下纤维化的临床研究[J].湖南中医药大学学报,2006,26(5):41-43.
[20] 李澜江,刘立亚,许静.中西医结合治疗口腔黏膜下纤维化的效果分析[J].当代医学,2017,23(13) :39-40.
[21] 刘一平.中药内服和局部封闭治疗口腔黏膜下纤维变性46例疗效观察[J].新中医,2006,38(6):54-55.
[22] 王玉平.以桃红四物汤为主治疗口腔黏膜下纤维化疗效观察[J].国际中医中药杂志,2014,36(10):945-946.
[23] 李轶,卢惠冰,彭植锋,等.玉泉汤对口腔黏膜下纤维性变的疗效及其作用机制[J].广东医学,2016,37(14):2188-2189.
[24] 蔡晖,宋力伟.甘草泻心合四妙勇安汤加减治疗口腔黏膜下纤维化临床观察[J].中华中医药学刊,2016,34(6):1486-1488.
[25] 赵翔宇.甘草泻心合四妙勇安汤加减治疗口腔黏膜下纤维化的临床观察[J].光明中医,2017,32(18):2655-2657.
[26] 姜彤,朱元松.自拟解纤饮治疗口腔黏膜下纤维化43例临床观察[J].中医药导报,2013,19(12):122-123.
[27] 杨新军,李蓬.疏肝活血方治疗口腔黏膜下纤维性变疗效分析[J].中国医药导报,2009,6(13):117-118.
[28] 李元聪.活血化瘀解毒法治疗口腔黏膜下纤维化60例[J].中医药导报,2012,18(3):86-87.
[2] 刘锦丽,陈方曼,江潞.口腔黏膜下纤维性变的药物治疗进展[J].国际口腔医学杂志,2017,44(3):325-331.
[3] 杨晨希,翦新春,潘英瑜,等.口腔黏膜下纤维性变治疗进展[J].海南医学,2017,28(20):3376-3378.
[4] Chole RH,Gondivkar SM,Gadbail AR,et al.Review of drug treatment of oral submucous fibrosis [J].Oral Oncol,2012,48(5):393-398.
[5] 张姗姗,凌天牖.口腔黏膜下纤维性变的治疗研究进展[J].口腔医学,2013,33(5):351-352.
[6] 谭劲,吴丹,刘寻,等.从虚瘀痰毒探讨口腔黏膜下纤维化的发病机制[J].湖南中医药大学学报,2016,36(3):38-39.
[7] Liu P,Liu CH,Wang HN,et al.Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells [J].Acta Phamacol Sin,2002,23(8):733-738.
[8] Lv Z,Xu L.Salvianolic acid B inhibits ERK and p38 MAPK Signaling in TGF-β1-stimulated human hapatic stellate cellline(LX-2) via distinct pathways [J].Evid Based Complement Alternat Med,2012,2012:1-11.
[9] Wang SX,Hu LM,Gao XM,et al.Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuro protective effect [J].Neurochem Res,2010,35(7):1029-1037.
[10] 翦新春,郑廉,朱蓉,等.曲安奈德和丹参酮注射液治疗口腔黏膜下纤维化的效果评价[J].中华口腔医学杂志,2017,52(1):16-21.
[11] 赵雁焕,徐梅,陆洋.丹参注射液联合曲安奈德局部注射治疗OSF的疗效及对血清TGF-β1、IL-6的影响[J].海南医学院学报,2017,23(5):673-679.
[12] 吴颖芳,彭解英,阙国鹰,等.中西医结合治疗口腔黏膜下纤维化的疗效[J].中南大学学报(医学版),2010,35(4):358-364.
[13] 张丽,龙卉,段开文.芦荟在口腔临床医学应用中的研究新进展[J].口腔医学,2017,37(3):285-288.
[14] Hamman JH.Composition and applications of Aloe vera leaf gel [J].Molecules,2008,13 (8):1599.
[15] Patil S,Halgatti V,Maheshwari S.Comparative study of the efficacy of herbal antioxdantsoxitard and aloe vera in the treatment of oral submucous fibrosis [J].J Clin Exp Dent,2014,6(3):e265-e270.
[16] Alam S,Ali I,Giri KY,et al.Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis [J].Oral Surg Oral Med Oral Pathol Oral Radiol,2013,116(6):717-724.
[17] Sudarshan R,Annigeri RG.Aloe vera in the treatment for oral submucous fibrosis apreliminary study [J].J Oral Pathol Med,2012,41(10):755-761.
[18] 左雯鑫,李晓宇,蔡淦英,等.复方丹参滴丸联合曲安奈德治疗口腔黏膜下纤维性变的临床研究[J].实用口腔医学杂志,2014,30(6):846-848.
[19] 谭劲,李元聪,陈安,等.丹玄口康治疗口腔黏膜下纤维化的临床研究[J].湖南中医药大学学报,2006,26(5):41-43.
[20] 李澜江,刘立亚,许静.中西医结合治疗口腔黏膜下纤维化的效果分析[J].当代医学,2017,23(13) :39-40.
[21] 刘一平.中药内服和局部封闭治疗口腔黏膜下纤维变性46例疗效观察[J].新中医,2006,38(6):54-55.
[22] 王玉平.以桃红四物汤为主治疗口腔黏膜下纤维化疗效观察[J].国际中医中药杂志,2014,36(10):945-946.
[23] 李轶,卢惠冰,彭植锋,等.玉泉汤对口腔黏膜下纤维性变的疗效及其作用机制[J].广东医学,2016,37(14):2188-2189.
[24] 蔡晖,宋力伟.甘草泻心合四妙勇安汤加减治疗口腔黏膜下纤维化临床观察[J].中华中医药学刊,2016,34(6):1486-1488.
[25] 赵翔宇.甘草泻心合四妙勇安汤加减治疗口腔黏膜下纤维化的临床观察[J].光明中医,2017,32(18):2655-2657.
[26] 姜彤,朱元松.自拟解纤饮治疗口腔黏膜下纤维化43例临床观察[J].中医药导报,2013,19(12):122-123.
[27] 杨新军,李蓬.疏肝活血方治疗口腔黏膜下纤维性变疗效分析[J].中国医药导报,2009,6(13):117-118.
[28] 李元聪.活血化瘀解毒法治疗口腔黏膜下纤维化60例[J].中医药导报,2012,18(3):86-87.