基于体素模型的多孔结构骨支架快速建模
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摘要
为解决组织工程骨支架多孔结构设计建模问题,提出1种基于体素模型的多孔体骨支架建模方法。基于CT断层扫描图像,采用MC算法3维重建骨支架三角网格模型;采用分区划分,逆向追踪求交分层算法,获取骨支架分层截面轮廓线段;基于离散采样法,对分层截面轮廓线段等距扫描线填充、离散,生成骨支架体素化模型;构建孔隙单元结构,以体素化空间为约束边界,通过孔隙单元"映射",构建出多孔骨支架模型。研究结果表明,所提算法可以快速构建出能够构建孔隙结构可控的多孔模型,从而为骨支架建模提供了1种可行性的方法。
Bone scaffold is an ideal method to treat bone defect,but how to construct the porous structure of the bone scaffold. Based on the voxelization method,a new bone modeling method is proposed. Firstly,based on CT tomography image,the triangular mesh model of bone scaffold is reconstructed by MC algorithm. Then,through partition,reverse tracking and intersection layer algorithm,the contour line segment of the layered cross section of bone scaffold is obtained from the triangular mesh model. On this basis,an isometric scan line is filled and dispersed to construct voxel model of bone scaffold by discrete sampling method. Finally,the pore unit structure is constructed and the porous bone scaffold model is designed by " mapping" of the pore unit. The results of case study show that the porous distribution can be achieved by the proposed method,which provide a feasible method for the modeling of bone scaffold.
Bone scaffold is an ideal method to treat bone defect,but how to construct the porous structure of the bone scaffold. Based on the voxelization method,a new bone modeling method is proposed. Firstly,based on CT tomography image,the triangular mesh model of bone scaffold is reconstructed by MC algorithm. Then,through partition,reverse tracking and intersection layer algorithm,the contour line segment of the layered cross section of bone scaffold is obtained from the triangular mesh model. On this basis,an isometric scan line is filled and dispersed to construct voxel model of bone scaffold by discrete sampling method. Finally,the pore unit structure is constructed and the porous bone scaffold model is designed by " mapping" of the pore unit. The results of case study show that the porous distribution can be achieved by the proposed method,which provide a feasible method for the modeling of bone scaffold.
引文
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[14]马小虎,潘志庚,石教英.基于三角形移去准则的多面体模型简化方法[J].计算机学报,1998,21(6):492-498.
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[2] LIANG H J,LI R Y,LIU G C,et al. Design of the porous orthopedic implants:research and application status[J]. Chinese Journal of Tissue Engineering Research,2017,21(15):2410-2417.
[3]金嘉长,王扬,马维虎,等. 3D生物打印技术在组织工程支架构建与再生中的应用进展[J].航天医学与医学工程,2016,29(6):462-468.
[4]邵惠锋,贺永,傅建中.增材制造可降解人工骨的研究进展——从外形定制到性能定制[J].浙江大学学报:工学版,2018(3):1-22.
[5]李林升,谢家龙,林国湘,等.人工骨个性化定制与激光快速成型[J].机械设计与研究,2016,32(4):132-134.
[6] WU W Z,ZHANG Y,LI H,et al. Fabrication of repairing skull bone defects based on the rapid prototyping[J]. J Bioact Compat Pol,2009,24(S1):125-136.
[7]张嘉宇,米雪,刘毅,等.3维打印组织工程牙计算机辅助设计建模技术的应用[J].中国组织工程研究,2015,19(38):6195-6199.
[8] PANDITHEVAN P,KUMAR G S. Finite element analysis of a personalized femoral scaffold with designed microarchitecture[J].Proc Inst Mech EngH,2010,224(7):877-889.
[9]蔡升勇.基于形函数控制的组织工程骨架孔隙分布结构实体建模技术研究[D].上海:上海交通大学,2010.
[10]尤飞,姚远,胡庆夕.仿生骨支架微观孔结构的构建与评价[J].机械工程学报,2011,47(1):138-144.
[11]尤飞,胡庆夕,朱晓锦.再生骨支架内部结构性能的综合评价[J].中国机械工程,2013,24(20):2768-2774.
[12] CHANTARAPANICH N, PUTTAWIBUL P,SUCHARITPWATSKUL S, et al. Scaffold library for tissue engineering:a geometric evaluation[J]. Computational&Mathematical Methods in Medicine,2012,2012(3):565-569.
[13]汪焰恩,王月波,杨明明,等.基于知识库的骨支架可控分形设计[J].西北工业大学学报,2013,31(5):779-784.
[14]马小虎,潘志庚,石教英.基于三角形移去准则的多面体模型简化方法[J].计算机学报,1998,21(6):492-498.
[15]余伟巍,何飞,席平.针对脊柱CT图像3维重构MC方法的改进[J].计算机工程与应用,2010,46(2):25-28.