血清巨噬细胞迁移抑制因子与稳定型心绞痛合并高血压患者发生主要不良心血管事件的相关性研究
|
摘要
目的探讨外周血血清巨噬细胞迁移抑制因子(MIF)表达水平与稳定型心绞痛(SAP)合并高血压患者主要心血管不良事件(MACE)的相关性。方法选取2015年7月至2016年12月于荆门市第二人民医院就诊的119例SAP患者(分为SAP合并高血压组和SAP不合并高血压组),另外选择45例健康志愿者作为对照组。检测SAP合并高血压患者和不合并高血压患者及对照组一般情况(性别、年龄及体质指数)、血清MIF水平,并采用多因素Logistic回归模型分析血清MIF水平与SAP合并高血压患者发生MACE的关系。结果随访期间,SAP合并高血压组共30例(44.12%)患者发生MACE,其发病率明显高于SAP不合并高血压组患者(P<0.05)。SAP合并高血压组患者发生MACE患者血清MIF水平明显高于未发生MACE患者(P<0.05)。但是SAP不合并高血压患者发生MACE患者和未发生MACE患者血清MIF水平基本一致(P>0.05)。经Logistic多因素相关性分析,MIF升高是SAP合并高血压患者发生MACE的独立危险因素(P<0.05)。结论血清高水平MIF与稳定型心绞痛合并高血压患者发生MACE具有一定的相关性,可作为患者预后的独立预测指标,值得临床关注。
Objective To discuss the correlation between expression of serum macrophage migration inhibitory factor(MIF) in peripheral blood and major adverse cardiovascular events(MACE) in patients with stable angina pectoris(SAP) complicated by hypertension. Methods SAP patients(n=119, SAP with hypertension group and SAP without hypertension group) and healthy controls(n=45, control group) were chosen from the Second People's Hospital of Jingmen City from July 2015 to Dec. 2016. The general data [sex, age and body mass index(BMI)]and level of serum MIF were detected in all groups. The relationship between MIF level and MACE occurrence was analyzed by using multi-factor Logistic regression model in SAP with hypertension group. Results During follow-up period, MACE occurred in 30 cases(44.12%) in SAP with hypertension group, and the morbidity was significantly higher than that in SAP without hypertension group(P<0.05). The level of serum MIF was significantly higher in MACE patients than that in non-MACE patients in SAP with hypertension group(P<0.05). The level of serum MIF was basically the same in MACE patients and non-MACE patients in SAP without hypertension group(P>0.05). The results of multi-factor Logistic correlation analysis showed that MIF increase was an independent risk factor of MACE occurrence in SAP with hypertension group(P<0.05). Conclusion The higher level of serum MIF is correlated to MACE occurrence in patients with SAP complicated by hypertension, which can be taken as an independent predictive index for patients' prognosis.
Objective To discuss the correlation between expression of serum macrophage migration inhibitory factor(MIF) in peripheral blood and major adverse cardiovascular events(MACE) in patients with stable angina pectoris(SAP) complicated by hypertension. Methods SAP patients(n=119, SAP with hypertension group and SAP without hypertension group) and healthy controls(n=45, control group) were chosen from the Second People's Hospital of Jingmen City from July 2015 to Dec. 2016. The general data [sex, age and body mass index(BMI)]and level of serum MIF were detected in all groups. The relationship between MIF level and MACE occurrence was analyzed by using multi-factor Logistic regression model in SAP with hypertension group. Results During follow-up period, MACE occurred in 30 cases(44.12%) in SAP with hypertension group, and the morbidity was significantly higher than that in SAP without hypertension group(P<0.05). The level of serum MIF was significantly higher in MACE patients than that in non-MACE patients in SAP with hypertension group(P<0.05). The level of serum MIF was basically the same in MACE patients and non-MACE patients in SAP without hypertension group(P>0.05). The results of multi-factor Logistic correlation analysis showed that MIF increase was an independent risk factor of MACE occurrence in SAP with hypertension group(P<0.05). Conclusion The higher level of serum MIF is correlated to MACE occurrence in patients with SAP complicated by hypertension, which can be taken as an independent predictive index for patients' prognosis.
引文
[1]Aboyans V,Sevestre MA,Désormais I,et al.Epidemiology of lower extremity artery disease[J].Presse Med,2018,47(1):38-46.
[2]高修仁.我国慢性稳定型心绞痛诊断与治疗指南解读[J].新医学,2007,38(11):704-7.
[3]Aoyama R,Takano H,Suzuki K,et al.The impact of blood pressure variability on coronary plaque vulnerability in stable angina:an analysis using optical coherence tomography[J].Coron Artery Dis,2017,28(3):225-31.
[4]Husain K,Hernandez W,Ansari RA,et al.Inflammation,oxidative stress and renin angiotensin system in atherosclerosis[J].World J Biol Chem,2015,6(3):209-17.
[5]赵然,姚伟娟.巨噬细胞迁移抑制因子的功能及临床研究进展[J].生理科学进展,2014,45(2):93-9.
[6]Montali A,BarillàF,Tanzilli G,et al.Functional rs20417 SNP(-765G>C)of cyclooxygenase-2 gene does not predict the risk of recurrence of ischemic events in coronary patients:results of a 7-year prospective study[J].Cardiology,2010,115(3):236-42.
[7]Zairi I,Mzoughi K,Jnifene Z,et al.Coronary-subclavian steal syndrome presenting with stable angina[J].Tunis Med,2017,95(4):315-6.
[8]Rothberg MB.PCI for stable angina:A missed opportunity for shared decision-making[J].Cleve Clin J Med,2018,85(2):105-21.
[9]陈建平.CT冠状动脉成像与冠状动脉造影诊断冠心病的临床价值对照分析[J].中国CT和MRI杂志,2016,15(1):49-51.
[10]胡其源,徐颖杰,岳静雯,等.血清标志物与冠心病患者动脉病变严重程度的关系[J].检验医学与临床,2017,14(14):2033-6.
[11]杨然,王显.急性冠脉综合征易损斑块的发病机理与早期检测[J].中国循证心血管医学杂志,2012,4(3):284-6.
[12]任广理,罗涛,侯伯轩,等.血浆炎症细胞因子与急性冠脉综合征的相关性研究[J].中国循证心血管医学杂志,2017,9(3):360-4.
[13]DuBrock HM,Rodriguez-Lopez JM,LeVarge BL,et al.Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension[J].Pulm Circ,2016,6(4):498-507.
[14]S.Matthijs Boekholdt,Ron J.G.Peters,Nicholas E.Day,et al.Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke:The EPIC-Norfolk Prospective Population study[J].The American Journal of Medicine,2014,117(6):390-7.
[15]Herder C,Illig T,Baumert J,et al.Macrophage migration inhibitory factor(MIF)and risk for coronary heart disease:results from the MONICA/KORA Augsburg case-cohort study,1984-2002[J].Athero sclerosis,2008,200(2):380-8.
[2]高修仁.我国慢性稳定型心绞痛诊断与治疗指南解读[J].新医学,2007,38(11):704-7.
[3]Aoyama R,Takano H,Suzuki K,et al.The impact of blood pressure variability on coronary plaque vulnerability in stable angina:an analysis using optical coherence tomography[J].Coron Artery Dis,2017,28(3):225-31.
[4]Husain K,Hernandez W,Ansari RA,et al.Inflammation,oxidative stress and renin angiotensin system in atherosclerosis[J].World J Biol Chem,2015,6(3):209-17.
[5]赵然,姚伟娟.巨噬细胞迁移抑制因子的功能及临床研究进展[J].生理科学进展,2014,45(2):93-9.
[6]Montali A,BarillàF,Tanzilli G,et al.Functional rs20417 SNP(-765G>C)of cyclooxygenase-2 gene does not predict the risk of recurrence of ischemic events in coronary patients:results of a 7-year prospective study[J].Cardiology,2010,115(3):236-42.
[7]Zairi I,Mzoughi K,Jnifene Z,et al.Coronary-subclavian steal syndrome presenting with stable angina[J].Tunis Med,2017,95(4):315-6.
[8]Rothberg MB.PCI for stable angina:A missed opportunity for shared decision-making[J].Cleve Clin J Med,2018,85(2):105-21.
[9]陈建平.CT冠状动脉成像与冠状动脉造影诊断冠心病的临床价值对照分析[J].中国CT和MRI杂志,2016,15(1):49-51.
[10]胡其源,徐颖杰,岳静雯,等.血清标志物与冠心病患者动脉病变严重程度的关系[J].检验医学与临床,2017,14(14):2033-6.
[11]杨然,王显.急性冠脉综合征易损斑块的发病机理与早期检测[J].中国循证心血管医学杂志,2012,4(3):284-6.
[12]任广理,罗涛,侯伯轩,等.血浆炎症细胞因子与急性冠脉综合征的相关性研究[J].中国循证心血管医学杂志,2017,9(3):360-4.
[13]DuBrock HM,Rodriguez-Lopez JM,LeVarge BL,et al.Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension[J].Pulm Circ,2016,6(4):498-507.
[14]S.Matthijs Boekholdt,Ron J.G.Peters,Nicholas E.Day,et al.Macrophage migration inhibitory factor and the risk of myocardial infarction or death due to coronary artery disease in adults without prior myocardial infarction or stroke:The EPIC-Norfolk Prospective Population study[J].The American Journal of Medicine,2014,117(6):390-7.
[15]Herder C,Illig T,Baumert J,et al.Macrophage migration inhibitory factor(MIF)and risk for coronary heart disease:results from the MONICA/KORA Augsburg case-cohort study,1984-2002[J].Athero sclerosis,2008,200(2):380-8.