小剂量多巴胺治疗窒息后肾损害临床疗效及对新生儿呼气峰流速值、心率、平均动脉压水平影响
|
摘要
目的:研究小剂量多巴胺对窒息后肾损害新生儿的临床疗效及对呼气峰流速值(PET)、心率(HR)、平均动脉压(MAP)水平的影响。方法:选取息后肾损害新生儿120例。根据随机数字表法均分成研究组与对照组,每组60例。对照组患儿予以常规综合治疗,研究组则在常规综合治疗的基础上予以小剂量多巴胺治疗。比较两组临床疗效,治疗后PEF、HR、MAP水平,治疗前后血肌酐与尿素氮水平,脏器受损情况。结果:研究组治疗总有效率为95.00%(57/60),明显高于对照组的80.00%(48/60),差异有统计学意义(P<0.05)。治疗后研究组PEF、HR、MAP水平分别为(6.8±1.2)L/min、(76.5±11.8)次/min、(91.0±10.4)mmHg,均明显高于对照组的(5.9±1.0)L/min、(68.7±12.3)次/min、(82.2±11.5)mmHg,差异均有统计学意义(P<0.05)。治疗后研究组肌酐与尿素氮水平分别为(67.2±14.8)mmol/L、(5.2±1.2)μmol/L,均明显低于对照组的(87.4±18.2)mmol/L、(8.4±2.1)μmol/L,差异均有统计学意义(P<0.05)。治疗后研究组肾功能障碍发生率为13.33%(8/60),明显低于对照组的51.67%(31/60),差异有统计学意义(P<0.05)。结论:小剂量多巴胺治疗窒息后肾损害新生儿的临床疗效显著,可有效改善患儿PEF、HR、MAP水平,有利于改善患儿肾功能,具有较高的临床价值。
Objective:To study the small dose dopamine clinical curative effect of renal damage after asphyxia newborn and the expiratory peak velocity value(PET),heart rate(HR),mean arterial pressure(MAP)level.Methods:120 cases of neonatal injury after asphyxiation were selected.The random digital table method was divided into the study group and the control group,60 cases in each group.The children in the control group received routine comprehensive treatment,and the study group received a small dose of dopamine treatment on the basis of routine comprehensive treatment.The clinical efficacy of the two groups was compared.After treatment,PEF,HR and MAP were treated,and the blood creatinine and urea nitrogen levels were compared before and after treatment.Results:The total effective rate was 95.00%(57/60),which was significantly higher than 80.00%(48/60)in the control group,and the difference was statistically significant(P <0.05).Team PEF,HR and MAP level after treatment respectively was(6.8±1.2)L/min,(76.5±11.8)times/min,(91.0±10.4)mmHg,which was significantly higher than that of control group(5.9±1.0)L/min,(68.7±12.3)times/min,(82.2±11.5)mmHg,differences were statistically significant(all P<0.05).Team of creatinine and urea nitrogen levels after treatment respectively was(67.2±14.8)mmol/L,(5.2±1.2)μmol/L,which were significantly lower than in the control group(87.4±18.2)mmol/L,(8.4±2.1)μmol/L,the differences were statistically significant(all P <0.05).After treatment,the incidence of renal dysfunction was 13.33%(8/60),was significantly lower than the control group of 51.67%(31/60),and the difference was statistically significant(P<0.05).Conclusion:Small dose of dopamine in the treatment of renal damage after asphyxia newborn curative effect significantly,can effectively improve children PEF,HR,MAP,and can help children improve renal function,has high clinical value.
Objective:To study the small dose dopamine clinical curative effect of renal damage after asphyxia newborn and the expiratory peak velocity value(PET),heart rate(HR),mean arterial pressure(MAP)level.Methods:120 cases of neonatal injury after asphyxiation were selected.The random digital table method was divided into the study group and the control group,60 cases in each group.The children in the control group received routine comprehensive treatment,and the study group received a small dose of dopamine treatment on the basis of routine comprehensive treatment.The clinical efficacy of the two groups was compared.After treatment,PEF,HR and MAP were treated,and the blood creatinine and urea nitrogen levels were compared before and after treatment.Results:The total effective rate was 95.00%(57/60),which was significantly higher than 80.00%(48/60)in the control group,and the difference was statistically significant(P <0.05).Team PEF,HR and MAP level after treatment respectively was(6.8±1.2)L/min,(76.5±11.8)times/min,(91.0±10.4)mmHg,which was significantly higher than that of control group(5.9±1.0)L/min,(68.7±12.3)times/min,(82.2±11.5)mmHg,differences were statistically significant(all P<0.05).Team of creatinine and urea nitrogen levels after treatment respectively was(67.2±14.8)mmol/L,(5.2±1.2)μmol/L,which were significantly lower than in the control group(87.4±18.2)mmol/L,(8.4±2.1)μmol/L,the differences were statistically significant(all P <0.05).After treatment,the incidence of renal dysfunction was 13.33%(8/60),was significantly lower than the control group of 51.67%(31/60),and the difference was statistically significant(P<0.05).Conclusion:Small dose of dopamine in the treatment of renal damage after asphyxia newborn curative effect significantly,can effectively improve children PEF,HR,MAP,and can help children improve renal function,has high clinical value.
引文
[1]Li ES,G9rens I,Cheung PY,et al.Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia[J].Neonatology,2017,112(4):337-346.
[2]陈强.胱抑素C和β2微球蛋白检测在新生儿窒息后早期肾脏损害中的诊断价值[J].河南医学研究,2016,25(12):2249-2250.
[3]李自锋.小剂量多巴胺治疗新生儿窒息后肾损害的效果观察[J].临床合理用药杂志,2016,9(27):14-15.
[4]樊彩英.小剂量多巴胺治疗新生儿窒息后肾损害的临床疗效观察[J].基层医学论坛,2015,1(5):606-607.
[5]Ndombo PK,Ekei QM,Tochie JN,et al.A cohort analysis of neonatal hospital mortality rate and predictors of neonatal mortality in a sub-urban hospital of Cameroon[J].Ital J Pediatr,2017,43(1):52-52.
[6]王燕彬,张惠荣,潘金勇,等.热休克蛋白70和NBNA评分与新生儿窒息的相关性研究[J].中华新生儿科杂志(中英文),2017,32(1):35-38.
[7]安雪霞,殷爱云,陈之华,等.新生儿窒息后不同时期肾功能检测的临床意义[J].淮海医药,2013,31(1):15-16.
[8]罗德春,王君霞,梁玲,等.尿微量蛋白在新生儿窒息肾损害早期诊断中的意义[J].中国急救复苏与灾害医学杂志,2014,9(6):500-502.
[9]张芳,杨国颖.肿瘤坏死因子-α及转化生长因子-β1在窒息新生儿肾损害中的变化[J].中国妇幼保健,2014,29(14):2187-2188.
[10]蒋国美,赖春华,彭嘉恒,等.重度窒息新生儿胃肠功能障碍与多器官功能损害的相关性研究[J].白求恩医学杂志,2017,15(3):286-288.
[2]陈强.胱抑素C和β2微球蛋白检测在新生儿窒息后早期肾脏损害中的诊断价值[J].河南医学研究,2016,25(12):2249-2250.
[3]李自锋.小剂量多巴胺治疗新生儿窒息后肾损害的效果观察[J].临床合理用药杂志,2016,9(27):14-15.
[4]樊彩英.小剂量多巴胺治疗新生儿窒息后肾损害的临床疗效观察[J].基层医学论坛,2015,1(5):606-607.
[5]Ndombo PK,Ekei QM,Tochie JN,et al.A cohort analysis of neonatal hospital mortality rate and predictors of neonatal mortality in a sub-urban hospital of Cameroon[J].Ital J Pediatr,2017,43(1):52-52.
[6]王燕彬,张惠荣,潘金勇,等.热休克蛋白70和NBNA评分与新生儿窒息的相关性研究[J].中华新生儿科杂志(中英文),2017,32(1):35-38.
[7]安雪霞,殷爱云,陈之华,等.新生儿窒息后不同时期肾功能检测的临床意义[J].淮海医药,2013,31(1):15-16.
[8]罗德春,王君霞,梁玲,等.尿微量蛋白在新生儿窒息肾损害早期诊断中的意义[J].中国急救复苏与灾害医学杂志,2014,9(6):500-502.
[9]张芳,杨国颖.肿瘤坏死因子-α及转化生长因子-β1在窒息新生儿肾损害中的变化[J].中国妇幼保健,2014,29(14):2187-2188.
[10]蒋国美,赖春华,彭嘉恒,等.重度窒息新生儿胃肠功能障碍与多器官功能损害的相关性研究[J].白求恩医学杂志,2017,15(3):286-288.