口服常乐康对HIV母婴阻断新生儿的胃肠功能、生长发育的影响
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摘要
目的 :观察HIV母婴阻断新生儿口服常乐康(酪酸梭菌二联活菌散)后胃肠功能、生长发育情况。方法 :将105例HIV母婴阻断新生儿随机分为治疗组54例与对照组51例。两组新生儿出生后4～6 h内给予抗病毒阻断治疗,至出生后28 d。治疗组于开奶后2 h在常规治疗上基础上口服常乐康500 mg/次,2次/d,疗程为2周。对照组不加服任何益生菌制剂。观察出生28 d两组新生儿胃肠功能、生长发育及不良反应发生情况。结果 :治疗组胃肠功能、生长发育均优于对照组、不良反应发生率低于对照组(P均<0.05)。结论:口服常乐康能改善HIV母婴阻断新生儿胃肠功能,促进生长发育,降低喂养不耐受及坏死性小肠结肠炎的发生率。
Objective: To observe the gastrointestinal function, growth and development of neonates after oral Changlekang. Methods: One hundred and five neonates with HIV interruption were randomly divided into an observation group(54 cases) and a control group(51 cases). All the neonates were given antiviral blocking treatment within 4-6 hours after birth till 28 days. The observation group was given Changlekang(500 mg each time, twice a day) for 2 weeks on the basis of the control group which was not given any probiotics. The gastrointestinal function, growth and development and adverse reactions were observed in the two groups at 28 days of birth. Results: The gastrointestinal function, growth and development were much better and the incidence of adverse reactions was lower in the observation group than the control group(P<0.05).Conclusion: Oral Changlekang can effectively improve the gastrointestinal function, promote growth and development and reduce the incidence of feeding intolerance and necrotizing enterocolitis.
Objective: To observe the gastrointestinal function, growth and development of neonates after oral Changlekang. Methods: One hundred and five neonates with HIV interruption were randomly divided into an observation group(54 cases) and a control group(51 cases). All the neonates were given antiviral blocking treatment within 4-6 hours after birth till 28 days. The observation group was given Changlekang(500 mg each time, twice a day) for 2 weeks on the basis of the control group which was not given any probiotics. The gastrointestinal function, growth and development and adverse reactions were observed in the two groups at 28 days of birth. Results: The gastrointestinal function, growth and development were much better and the incidence of adverse reactions was lower in the observation group than the control group(P<0.05).Conclusion: Oral Changlekang can effectively improve the gastrointestinal function, promote growth and development and reduce the incidence of feeding intolerance and necrotizing enterocolitis.
引文
[1]陈胜林,李鹏,李科峰.舟山市艾滋病母婴传播阻断综合干预效果评价[J].预防医学,2017,29(2):132-134.
[2]董志巧,程书卿,张辉果,等.口服常乐康早产低出生体重儿的胃肠功能、生长发育情况观察[J].山东医药,201757(3):79-81.
[3]中华预防医学会微生态学分会儿科学组.益生菌儿科临床应用循证指南[J].中国实用儿科杂志,2017,32(2):81-90.
[4]吴炜林,程周祥,王睿,等.艾滋病感染孕产妇15例母婴阻断综合干预措施探讨[J].中国妇幼健康研究,201425(1):66-68.
[5]王慧,张欢欢.抗病毒治疗阻断艾滋病母婴传播途径及孕产妇治疗依从性影响因素研究[J].中国性科学,201726(3):137-140.
[6]马丙南.穴位按压防治HIV母婴阻断新生儿喂养不耐受的疗效观察[J].中国中西医结合儿科学,2017,9(3):194-197.
[7]陈艳娟,谢润华,余文霞,等.微生态制剂对早产儿喂养不耐受及早期生长发育的影响[J].中华实用儿科临床杂志,2008,23(14):1108-1109.
[8]傅思武,邝欣,邹开勇,等.酪酸梭菌--婴儿型双歧杆菌二联活菌制剂对人体肠道菌群的调节试验[J].中国微生态学杂志,2000,12(6):334-335.
[9]Rautava S.Potential uses of probiotics in the neonate[J]Semin Fetal Neonatal Med,2007,12(1):45-53.
[10]白春然.常乐康联合消旋卡多曲治疗婴幼儿腹泻疗效观察[J].河北医学,2013,19(4):568-570.
[11]李琳,李岩.整肠生联合常乐康治疗伴肠道菌群失调功能性腹泻的疗效观察[J].中国微生态学杂志,2014,26(3):284-289.
[12]丁晓燕.益生菌在预防早产儿坏死性小肠结肠炎中的作用探讨[J].世界临床医学,2017,11(9):96-97.
[13]Santocchi E,Guiducci L,Fulceri F,et al.Gut to brain interaction in autism spectrum disorders:a randomized controlled trial on the role of probiotics on clinical biochemical and neuro physiological parameters[J/OL].BMCPsychiatry,2016,16:183.doi:10.1186/s12888-016-0887-5.
[2]董志巧,程书卿,张辉果,等.口服常乐康早产低出生体重儿的胃肠功能、生长发育情况观察[J].山东医药,201757(3):79-81.
[3]中华预防医学会微生态学分会儿科学组.益生菌儿科临床应用循证指南[J].中国实用儿科杂志,2017,32(2):81-90.
[4]吴炜林,程周祥,王睿,等.艾滋病感染孕产妇15例母婴阻断综合干预措施探讨[J].中国妇幼健康研究,201425(1):66-68.
[5]王慧,张欢欢.抗病毒治疗阻断艾滋病母婴传播途径及孕产妇治疗依从性影响因素研究[J].中国性科学,201726(3):137-140.
[6]马丙南.穴位按压防治HIV母婴阻断新生儿喂养不耐受的疗效观察[J].中国中西医结合儿科学,2017,9(3):194-197.
[7]陈艳娟,谢润华,余文霞,等.微生态制剂对早产儿喂养不耐受及早期生长发育的影响[J].中华实用儿科临床杂志,2008,23(14):1108-1109.
[8]傅思武,邝欣,邹开勇,等.酪酸梭菌--婴儿型双歧杆菌二联活菌制剂对人体肠道菌群的调节试验[J].中国微生态学杂志,2000,12(6):334-335.
[9]Rautava S.Potential uses of probiotics in the neonate[J]Semin Fetal Neonatal Med,2007,12(1):45-53.
[10]白春然.常乐康联合消旋卡多曲治疗婴幼儿腹泻疗效观察[J].河北医学,2013,19(4):568-570.
[11]李琳,李岩.整肠生联合常乐康治疗伴肠道菌群失调功能性腹泻的疗效观察[J].中国微生态学杂志,2014,26(3):284-289.
[12]丁晓燕.益生菌在预防早产儿坏死性小肠结肠炎中的作用探讨[J].世界临床医学,2017,11(9):96-97.
[13]Santocchi E,Guiducci L,Fulceri F,et al.Gut to brain interaction in autism spectrum disorders:a randomized controlled trial on the role of probiotics on clinical biochemical and neuro physiological parameters[J/OL].BMCPsychiatry,2016,16:183.doi:10.1186/s12888-016-0887-5.