日粮纤维调节猪肠道微生物和肠黏膜屏障功能的研究进展
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摘要
仔猪腹泻难题制约生猪养殖水平的提高。随着高铜、高锌、抗生素的限用禁用,仔猪腹泻亟需"绿色"替代方案。日粮纤维作为第六大营养素,具有维持肠道健康的生理功能。日粮纤维可以通过优化肠道菌群结构,调节黏膜屏障等作用促进猪肠道的健康发育与完整功能实现。文章就日粮纤维对猪肠道微生物以及黏膜屏障功能的可能作用途径以及相关作用机制进行综述,以促进日粮纤维在猪日粮生产上应用,尤其是仔猪日粮生产上的合理广泛利用。
The diarrhea restricts the raising of pig industry level. With the prohibition of high copper,high zinc and antibiotic, piglet diarrhea needs "green" alternative to be solved. As the sixth major nu-trients, dietary fiber has the physiological function of maintaining intestinal health. Dietary fiber canpromote the function of pig's intestine by optimizing the structure of intestinal microbiota and regulat-ing the mucosal barrier. In this review, we summarized the possible regulation mechanisms of dietaryfiber on intestinal microbiota and mucosal barrier function in pigs, the aim to promote rational and ex-tensive use of dietary fiber in pig diets, especially in piglets.
The diarrhea restricts the raising of pig industry level. With the prohibition of high copper,high zinc and antibiotic, piglet diarrhea needs "green" alternative to be solved. As the sixth major nu-trients, dietary fiber has the physiological function of maintaining intestinal health. Dietary fiber canpromote the function of pig's intestine by optimizing the structure of intestinal microbiota and regulat-ing the mucosal barrier. In this review, we summarized the possible regulation mechanisms of dietaryfiber on intestinal microbiota and mucosal barrier function in pigs, the aim to promote rational and ex-tensive use of dietary fiber in pig diets, especially in piglets.
引文
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[21]C.L.Dikeman,G.C.Fahey Jr.Viscosity as related to dietary fiber:a review[J].Critical reviews in food science and nutrition2006,46:649-663.
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[30]T.Looft,H.K.Allen,B.L.Cantarel,et al.Henrissat and T.B.Stanton,Bacteria,phages and pigs:the effects of in-feed antibiotics on the microbiome at different gut locations[J].Isme Journal,2014,8:1566-1576.
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[32]M.E.V.Johansson,J.M.H.Larsson,G.C.Hansson.The two mucus layers of colon are organized by the MUC2 mucin,whereas the outer layer is a legislator of host-microbial interactions[J].Proceedings of the National Academy of Sciences of the United States of America,2011,108:4659-4665.
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[35]H.Ito,M.Satsukawa,E.Arai,et al.Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats[J].Journal of Nutrition,2009,139:1640-1647.
[36]S.Hino,N.Takemura,K.Sonoyama,et al.Small intestinal goblet cell proliferation induced by ingestion of soluble and insoluble dietary fiber is characterized by an increase in sialylated mucins in rats[J].Journal of Nutrition,2012,142:1429.
[37]M.S.Desai,A.M.Seekatz,N.M.Koropatkin,et al.A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility[J].Cell,2016,1671339-1353.
[38]H.Chen,W.Wang,J.Degroote,et al.Arabinoxylan in Wheat Is More Responsible Than Cellulose for Promoting Intestinal Barrier Function in Weaned Male Piglets[J].The Journal of nutrition2015,145:51-58.
[39]L.Chen,H.Zhang,L.Gao,et al.Effect of graded levels of fiber from alfalfa meal on intestinal nutrient and energy flow,and hindgut fermentation in growing pigs[J].Journal of animal science,2013,91:4757-4764.
[40]J.Zou,B.Chassaing,V.Singh,et al.Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health[J].Cell Host&Microbe,2017,23:41.
[41]O.T.Foye,I-FeiHuang,C.C.Chiou,et al.Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7cell signaling[J].Fems Immunology&Medical Microbiology2012,65:467-480.
[42]J.Kovacsnolan,H.Kanatani,A.Nakamura,et al.β-1,4-mannobiose stimulates innate immune responses and induces TLR4-dependent activation of mouse macrophages but reduces severity of inflammation during endotoxemia in mice[J].Journal of Nutrition,2013,143:384.
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