DNA疫苗在自身免疫性疾病中的研究进展
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摘要
自身免疫性疾病(autoimmune disease,AID)是一类因机体免疫耐受功能受损而致免疫细胞及其成分对自身组织结构和功能破坏,并出现一定临床表现的疾病。AID发病机制复杂,尚缺乏有效的治疗手段,因而严重影响患者的生活质量。基因疫苗又称DNA疫苗,从wolff等人首次提出至今,已在预防感染、AID及肿瘤等相关领域的研究中取得显著成效。本文就DNA疫苗在AID治疗中的应用及研究进展做一综述,以期为AID的临床治疗提供理论依据。
Autoimmune disease(AID) is a kind of diseases in which immune structure and function are destroyed by immune cells and their components due to immune tolerance damage, appearing many clinical manifestations. The pathogenesis of AID is complex and there is still no effective treatment, thus AID seriously affects the quality of life of patients. Gene vaccines, known as DNA vaccines, have been published in the related fields of the prevention of infection, AID and tumors, and have achieved remarkable results since the first proposed by Wolff et al. This article reviews the application and research progress of DNA vaccine in AID treatment, to provide a theoretical basis for the clinical treatment of AID.
Autoimmune disease(AID) is a kind of diseases in which immune structure and function are destroyed by immune cells and their components due to immune tolerance damage, appearing many clinical manifestations. The pathogenesis of AID is complex and there is still no effective treatment, thus AID seriously affects the quality of life of patients. Gene vaccines, known as DNA vaccines, have been published in the related fields of the prevention of infection, AID and tumors, and have achieved remarkable results since the first proposed by Wolff et al. This article reviews the application and research progress of DNA vaccine in AID treatment, to provide a theoretical basis for the clinical treatment of AID.
引文
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[16]Juan L,Xiao Z,Song Y,et al.Safety and immunogenicity of a novel therapeutic DNA vaccine encoding chicken typeⅡcollagen for rheumatoid arthritis in normal rats[J].Hum Vaccin Immunother,2015,11(12):2777-2783.
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[18]Zagury D,Le Buanec H,Mathian A,et al.IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model[J].Proc Natl Acad Sci USA,2009,106(13):5294-5299.
[19]Favoino E,Favia EI,Digiglio L,et al.Effects of adjuvants for human use in systemic lupus erythematosus(SLE)-prone(New Zealand black/New Zealand white)F1 mice[J].Clin Exp Immunol,2014,175(1):32-40.
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[21]Castor T,Yogev N,Blank T,et al.Inhibition of experimental autoimmune encephalomyelitis by tolerancepromoting DNA vaccination focused to dendritic cells[J].PLoS One,2018,13(2):e0191927.
[22]Pagni PP,Bresson D,Rodriguez Calvo T,et al.Combination therapy with an anti-IL-1βantibody and GAD65 DNAvaccine can reverse recent-onset diabetes in the RIP-GPmouse model[J].Diabetes,2014,63(6):2015-2025.
[23]焦凤萍,郑绮菡,王玉,等.HSV-2gD、HBsAg和IL18多表位基因疫苗的构建方法[J].免疫学杂志,2012,28(4):337-340.
[24]陈泽锋,白丽.抗肿瘤多肽类药物的来源及其机制的研究进展[J].免疫学杂志,2018,34(12):1099-1104.
[2]Lawless OJ,Bellanti JA,Brown ML,et al.In vitro induction of T regulatory cells by a methylated CpG DNAsequence in humans:Potential therapeutic applications in allergic and autoimmune diseases[J].Allergy Asthma Proc,2018,39(2):143-152.
[3]Isshiki M,Zhang X,Sato H,et al.Effects of different promoters on the virulence and immunogenicity of a HIV-1Env-expressing recombinant vaccinia vaccine[J].Vaccine,2014,32(7):839-845.
[4]Csordas BG,Cunha RC,Garcia MV,et al.Molecular characterization of the recombinant protein RmLTI-BmCG-LTB:Protective immunity against Rhipicephalus(Boophilus)microplus[J].PLoS One,2018,13(2):e0191596.
[5]Wheelock A,Miraldo M,Parand A,et al.Journey to vaccination:a protocol for a multinational qualitative study[J].BMJ Open,2014,4(1):e004279.
[6]Herzog C.Influence of parenteral administration routes and additional factors on vaccine safety and immunogenicity:a review of recent literature[J].Expert Rev Vaccines,2014,13(3):399-415.
[7]Bayer L,Gümpel J,Hause G,et al.Non-human papillomaviruses for gene delivery in vitro and in vivo[J].PLoS One,2018,13(6):e0198996.
[8]Tucker SN,Lin K,Stevens S,et al.Salivary gland genetic vaccination:a scalable technology for promoting distal mucosal immunity and heightened systemic immune responses[J].Vaccine,2004,22(19):2500-2504.
[9]Fynan EF,Webster RG,Fuller DH,et al.DNA vaccines:protective immunizations by parenteral,mucosal,and genegun inoculations[J].Proc Natl Acad Sci USA,1993,90(24):11478-11482.
[10]Yurina V.Live bacterial vectors-a promising DNA vaccine delivery system[J].Med Sci(Basel),2018,6(2):E27.
[11]楚琰,吴兴安.DNA疫苗及其免疫途径的研究进展[J].中国医药生物技术,2010,5(4):285-288.
[12]Racz R,Li X,Patel M,et al.DNAVaxDB:the first webbased DNA vaccine database and its data analysis[J].BMCBioinformatics,2014,15(Suppl 4):S2.
[13]Guo X,Zhong JY,Li JW.Hepatitis C virus infection and vaccine development[J].J Clin Exp Hepatol,2018,8(2):195-204.
[14]Baranzini SE.The genetics of autoimmune diseases:a networked perspective[J].Curr Opin Immunol,2009,21(6):596-605.
[15]Chu C,Zhang W,Li J,et al.A single codon optimization enhances recombinant human TNF-αvaccine expression in Escherichia coli[J].Biomed Res Int,2018,2018:3025169.
[16]Juan L,Xiao Z,Song Y,et al.Safety and immunogenicity of a novel therapeutic DNA vaccine encoding chicken typeⅡcollagen for rheumatoid arthritis in normal rats[J].Hum Vaccin Immunother,2015,11(12):2777-2783.
[17]Zhang X,Liu S,Li S,et al.Designation of a novel DKK1multiepitope DNA vaccine and inhibition of bone loss in collagen-induced arthritic mice[J].Biomed Res Int,2015,2015:765490.
[18]Zagury D,Le Buanec H,Mathian A,et al.IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model[J].Proc Natl Acad Sci USA,2009,106(13):5294-5299.
[19]Favoino E,Favia EI,Digiglio L,et al.Effects of adjuvants for human use in systemic lupus erythematosus(SLE)-prone(New Zealand black/New Zealand white)F1 mice[J].Clin Exp Immunol,2014,175(1):32-40.
[20]Sonderegger I,Roha TA,Kurrer MO,et al.Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis[J].Eur J Immunol,2006,36:2849-2856.
[21]Castor T,Yogev N,Blank T,et al.Inhibition of experimental autoimmune encephalomyelitis by tolerancepromoting DNA vaccination focused to dendritic cells[J].PLoS One,2018,13(2):e0191927.
[22]Pagni PP,Bresson D,Rodriguez Calvo T,et al.Combination therapy with an anti-IL-1βantibody and GAD65 DNAvaccine can reverse recent-onset diabetes in the RIP-GPmouse model[J].Diabetes,2014,63(6):2015-2025.
[23]焦凤萍,郑绮菡,王玉,等.HSV-2gD、HBsAg和IL18多表位基因疫苗的构建方法[J].免疫学杂志,2012,28(4):337-340.
[24]陈泽锋,白丽.抗肿瘤多肽类药物的来源及其机制的研究进展[J].免疫学杂志,2018,34(12):1099-1104.