输卵管异常与体外受精反复失败的关系
|
摘要
反复体外受精(IVF)失败一直是辅助生殖过程中的痛点,输卵管一直被认为仅仅是一种用于运输的管道,忽略了其在胚胎着床过程中起到的重要作用。IVF反复失败的原因主要为胚胎因素,子宫内膜容受性以及其他因素。文章主要围绕各类输卵管病变对上述3个因素产生的影响,分析各种输卵管慢性炎性病变与IVF失败的关系。
Repeated IVF failure has been a pain pointin the assisted reproductive process.The fallopian tubehas long been considered as a conduit for transporta-tion,ignoring its important role in embryo implantation.The main reasons for the repeated failure of IVF areembryonic factors,endometrial receptivity and otherfactors.The article mainly focuses on the effects ofvarious types of fallopian tube lesions on the abovethree factors,and analyzes the relationship betweenvarious oviduct chronic inflammatory lesions and IVFfailure.IVFfallopian tube obstructionendome-
Repeated IVF failure has been a pain pointin the assisted reproductive process.The fallopian tubehas long been considered as a conduit for transporta-tion,ignoring its important role in embryo implantation.The main reasons for the repeated failure of IVF areembryonic factors,endometrial receptivity and otherfactors.The article mainly focuses on the effects ofvarious types of fallopian tube lesions on the abovethree factors,and analyzes the relationship betweenvarious oviduct chronic inflammatory lesions and IVFfailure.IVFfallopian tube obstructionendome-
引文
[1]全松.反复IVF失败的因素分析[C].中华医学会第六次全国生殖医学学术会议专刊,2012:2.
[2] Safdarian L,Najmi Z,Aleyasin A,et al.Recurrent IVF failure and hereditary thrombophilia[J].Iran J Reprod Med,2014,12(7):467-470.
[3]田海英,徐祥波,王蔼明,等.反复移植失败伴慢性子宫内膜炎不同检测方法比较及高危因素分析[J].中国计划生育学杂志,2017,25(4):263-266.
[4] Penzias AS.Recurrent IVF failure:other factors[J].Fertil Steril,2012,97(5):1033-1038.
[5] Garnero P,LandewéR,Boers M,et al.The oviduct:a neglected organ due for re-assessment in IVF[J].Reprod Biomed Online,2015,30(3):233-240.
[6] Marcia A,Heiko H,Henning TA,et al.Designing 3-dimensional in vitro oviduct culture systems to study mammalian fertilization and embryo production[J].Ann Biomed Eng,2017,45(7):1731-1744.
[7] Ezzati M,Djahanbakhch O,Arian.Tubal transport of gametes and embryos:a review of physiology and pathophysiology[J].Assist Reprod Genet,2014,31(10):1337-1347.
[8] Hess AP,Talbi S,Hamilton AE,et al.The human oviduct transcriptome reveals an anti-inflammatory,anti-angiogenic,secretory and matrix-stable environment during embryo transit[J].Reprod Biomed Online,2013,27:423-435.
[9] Siristatidis C,Vogiatzi P,Salamalekis G,et al.Granulocyte macrophage colony stimulating factor supplementation in culture media for subfertile women undergoing assisted reproduction technologies:a systematic review[J].Int J Endocrinol,2013,2013:704967.
[10] Aleyasin A,Abediasl Z,Nazari A,et al.Granulocyte colonystimulating factor in repeated IVF failure,a randomized tria[lJ].Reproduction,2016,151(6):637-642.
[11] Bromfield JJ,Schjenken JE,Chin PY,et al.Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring[J].Proc Nati Acad Sci USA,2014,111(6):2200-2205.
[12]朱慧莉,黄薇.输卵管性不孕的流行病学及病因[J].国际生殖健康/计划生育杂志,2016,35(3):212-216.
[13] Hong-chu B,Mei-mei W,Xin-rong W.Clinical application of operative hysteroscopy in treatment of complex hydrosalpinx prior to IVF[J].Reprod Med,2015,13(5):311-316.
[14]刘琨,马晓玲,胡俊平,等.IVF-ET中输卵管积水对超促排卵和胚胎的影响[J].中国优生与遗传杂志,2016,24(5):133-134.
[15]刘艳,孙莹璞.输卵管积水对辅助生殖影响机制的研究进展[J].国际生殖健康/计划生育杂志,2012,31(3):239-241.
[16] Gelbaya TA,Nardo LG,Fitzgerald CT,et al.Ovarian response to gonadotropins after laparoscopic salpingectomy or the division of fallopian tubes for hydrosalpinges[J].Fertil Steril,2006,85(5):1460-1468.
[17] Salzillo PL,Salzillo ME,Iannella I,et al.Sonographic aspects in the study of endometrial receptivity in women undergoing in vitro fertilization[J].Minerva Ginecol,2010,62(4):267-275.
[18] Tsiami A,Chaimani A,Mavridis D,et al.Surgical treatment for hydrosalpinx prior to in-vitro fertilization embryo transfer:a network meta-analysis[J].Ultrasound Obstet Gynecol,2016,48(4):434-445.
[19]郭丽娜,王旭平,吕翠婷,等.生殖器结核并输卵管阻塞的不孕症患者卵巢储备功能及超促排卵周期卵巢反应性变化[J].山东医药,2015,55(27):18-20.
[20]陈力,李爱斌,曹景云,等.双侧输卵管切除与双侧输卵管阻塞对体外受精-胚胎移植结局影响的系统评价[J].生殖医学杂志,2014,23(7):545-551.
[21]柯伊玲.输卵管性不孕症妊娠评估[D].上海:复旦大学,2014.
[22]熊艳敏,覃桂荣.子宫内膜容受性的研究新进展[J].医学综述,2014,20(1):7-9.
[23] Yiping Z,Jin L,Haitao W.Surgical treatment for hydrosalpinx increases the expression of integrinαvβ3 in the endometrium during the implantation window[J].Exp Ther Med,2012,4(3):415-418.
[24] Inan S,Giray G,Vatansever HS,et al.Immunolocalization of integrins and wbronectin in tubal pregnancy[J].Acta Histochem,2004,106:235-243.
[25]温梦乔,徐琳.不同原因不孕症中子宫内膜容受性的评价[J].实用妇科内分泌杂志(电子版),2017,4(3):14-15.
[26] Lessey BA.Adhesion molecules and implantation[J].J Reprod Immunol,2002,55(1-2):101-112.
[27] Young MF,Kerr JM,Termine JD,et al.cDNA cloning,mRNA distribution and heterogeneity,chromosomal location and RFLP analysis of human osteopontin(OPN)[J].Genomics,1990,7:491-502.
[28]张翠莲,谢娟珂,张少娣,等.控制性卵巢刺激中黄体期添加雌激素对小鼠子宫内膜组织胞饮突变化和白血病抑制因子表达的影响[J].中华妇产科杂志,2008,43:937-941.
[29] Li Y,Sun L,Zhao D,et al.Aberrant expression of leukemia inhibitory factor receptor(LIFR)and leukemia inhibitory factor(LIF)is associated with tubal pregnancy occurrence[J].Turkish J Med Sci,2015,45(1):214.
[30] Daftary GS,Troy PJ,Bagot CN,et al.Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells[J].Molec Endocrinol,2002,16(3):571.
[31]张雨婷.输卵管阻塞性不孕症患者的输卵管通畅度及形态的关联因素研究[D].北京:北京中医药大学,2016:1-9.
[32]徐楗荧,罗英,曲仕浩,等.子宫内膜异位症不孕患者腹腔镜术后IVF-ET妊娠结局影响因素分析[J].生殖医学杂志,2018,27(6):540-544.
[33] Davis AC,Goldberg JM.Extrapelvic endometriosis[J].Semin Reprod Med,2017,35:98-101.
[34]李安吉,俞超芹.子宫内膜异位症患者卵泡液微环境与不孕症发生相关性研究进展[J].生殖医学杂志,2016,25:83-87.
[35] Du H,Taylor HS.The role of hox genes in female reproductive tract development,adult function,and fertility[J].Cold Spring Harb Perspect Med,2015,6(1):a023002.
[2] Safdarian L,Najmi Z,Aleyasin A,et al.Recurrent IVF failure and hereditary thrombophilia[J].Iran J Reprod Med,2014,12(7):467-470.
[3]田海英,徐祥波,王蔼明,等.反复移植失败伴慢性子宫内膜炎不同检测方法比较及高危因素分析[J].中国计划生育学杂志,2017,25(4):263-266.
[4] Penzias AS.Recurrent IVF failure:other factors[J].Fertil Steril,2012,97(5):1033-1038.
[5] Garnero P,LandewéR,Boers M,et al.The oviduct:a neglected organ due for re-assessment in IVF[J].Reprod Biomed Online,2015,30(3):233-240.
[6] Marcia A,Heiko H,Henning TA,et al.Designing 3-dimensional in vitro oviduct culture systems to study mammalian fertilization and embryo production[J].Ann Biomed Eng,2017,45(7):1731-1744.
[7] Ezzati M,Djahanbakhch O,Arian.Tubal transport of gametes and embryos:a review of physiology and pathophysiology[J].Assist Reprod Genet,2014,31(10):1337-1347.
[8] Hess AP,Talbi S,Hamilton AE,et al.The human oviduct transcriptome reveals an anti-inflammatory,anti-angiogenic,secretory and matrix-stable environment during embryo transit[J].Reprod Biomed Online,2013,27:423-435.
[9] Siristatidis C,Vogiatzi P,Salamalekis G,et al.Granulocyte macrophage colony stimulating factor supplementation in culture media for subfertile women undergoing assisted reproduction technologies:a systematic review[J].Int J Endocrinol,2013,2013:704967.
[10] Aleyasin A,Abediasl Z,Nazari A,et al.Granulocyte colonystimulating factor in repeated IVF failure,a randomized tria[lJ].Reproduction,2016,151(6):637-642.
[11] Bromfield JJ,Schjenken JE,Chin PY,et al.Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring[J].Proc Nati Acad Sci USA,2014,111(6):2200-2205.
[12]朱慧莉,黄薇.输卵管性不孕的流行病学及病因[J].国际生殖健康/计划生育杂志,2016,35(3):212-216.
[13] Hong-chu B,Mei-mei W,Xin-rong W.Clinical application of operative hysteroscopy in treatment of complex hydrosalpinx prior to IVF[J].Reprod Med,2015,13(5):311-316.
[14]刘琨,马晓玲,胡俊平,等.IVF-ET中输卵管积水对超促排卵和胚胎的影响[J].中国优生与遗传杂志,2016,24(5):133-134.
[15]刘艳,孙莹璞.输卵管积水对辅助生殖影响机制的研究进展[J].国际生殖健康/计划生育杂志,2012,31(3):239-241.
[16] Gelbaya TA,Nardo LG,Fitzgerald CT,et al.Ovarian response to gonadotropins after laparoscopic salpingectomy or the division of fallopian tubes for hydrosalpinges[J].Fertil Steril,2006,85(5):1460-1468.
[17] Salzillo PL,Salzillo ME,Iannella I,et al.Sonographic aspects in the study of endometrial receptivity in women undergoing in vitro fertilization[J].Minerva Ginecol,2010,62(4):267-275.
[18] Tsiami A,Chaimani A,Mavridis D,et al.Surgical treatment for hydrosalpinx prior to in-vitro fertilization embryo transfer:a network meta-analysis[J].Ultrasound Obstet Gynecol,2016,48(4):434-445.
[19]郭丽娜,王旭平,吕翠婷,等.生殖器结核并输卵管阻塞的不孕症患者卵巢储备功能及超促排卵周期卵巢反应性变化[J].山东医药,2015,55(27):18-20.
[20]陈力,李爱斌,曹景云,等.双侧输卵管切除与双侧输卵管阻塞对体外受精-胚胎移植结局影响的系统评价[J].生殖医学杂志,2014,23(7):545-551.
[21]柯伊玲.输卵管性不孕症妊娠评估[D].上海:复旦大学,2014.
[22]熊艳敏,覃桂荣.子宫内膜容受性的研究新进展[J].医学综述,2014,20(1):7-9.
[23] Yiping Z,Jin L,Haitao W.Surgical treatment for hydrosalpinx increases the expression of integrinαvβ3 in the endometrium during the implantation window[J].Exp Ther Med,2012,4(3):415-418.
[24] Inan S,Giray G,Vatansever HS,et al.Immunolocalization of integrins and wbronectin in tubal pregnancy[J].Acta Histochem,2004,106:235-243.
[25]温梦乔,徐琳.不同原因不孕症中子宫内膜容受性的评价[J].实用妇科内分泌杂志(电子版),2017,4(3):14-15.
[26] Lessey BA.Adhesion molecules and implantation[J].J Reprod Immunol,2002,55(1-2):101-112.
[27] Young MF,Kerr JM,Termine JD,et al.cDNA cloning,mRNA distribution and heterogeneity,chromosomal location and RFLP analysis of human osteopontin(OPN)[J].Genomics,1990,7:491-502.
[28]张翠莲,谢娟珂,张少娣,等.控制性卵巢刺激中黄体期添加雌激素对小鼠子宫内膜组织胞饮突变化和白血病抑制因子表达的影响[J].中华妇产科杂志,2008,43:937-941.
[29] Li Y,Sun L,Zhao D,et al.Aberrant expression of leukemia inhibitory factor receptor(LIFR)and leukemia inhibitory factor(LIF)is associated with tubal pregnancy occurrence[J].Turkish J Med Sci,2015,45(1):214.
[30] Daftary GS,Troy PJ,Bagot CN,et al.Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells[J].Molec Endocrinol,2002,16(3):571.
[31]张雨婷.输卵管阻塞性不孕症患者的输卵管通畅度及形态的关联因素研究[D].北京:北京中医药大学,2016:1-9.
[32]徐楗荧,罗英,曲仕浩,等.子宫内膜异位症不孕患者腹腔镜术后IVF-ET妊娠结局影响因素分析[J].生殖医学杂志,2018,27(6):540-544.
[33] Davis AC,Goldberg JM.Extrapelvic endometriosis[J].Semin Reprod Med,2017,35:98-101.
[34]李安吉,俞超芹.子宫内膜异位症患者卵泡液微环境与不孕症发生相关性研究进展[J].生殖医学杂志,2016,25:83-87.
[35] Du H,Taylor HS.The role of hox genes in female reproductive tract development,adult function,and fertility[J].Cold Spring Harb Perspect Med,2015,6(1):a023002.