伴和不伴热性惊厥史颞叶癫痫患者的临床特征及托吡酯疗效比较
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摘要
目的:分析颞叶癫痫(TLE)伴和不伴热性惊厥(FS)史两组患者的临床特征及托吡酯治疗疗效差别。方法:收集41例TLE患者的临床资料,据其是否伴FS史分为两组,分别比较两组患者临床特征、托吡酯治疗有效率、保留率以及副作用。结果:TLE伴和不伴FS两组分别在男女比例、年龄、起病年龄、出生缺血缺氧史均无统计学差异,但TLE伴FS组癫痫家族史明显高于不伴FS组。TLE伴和不伴FS两组患者托吡酯治疗的有效率、1年无发作率、副作用发生率及3个月、6个月和1年保留率均无明显统计学差异。结论:TLE和既往高热惊厥史关系仍不明确。托吡酯是一种治疗TLE相对安全、有效的药物。
Objective To compare the clinical features and topiramate(TPM) efficacy of temporal lobe epilepsy(TLE)with and without febrile seizures(FS). Methods The clinical data were collected, including age,gender,history of epilepsy,history of febrile seizures,electroencephalograms, brain magnetic resonance imaging(MRI),dose of TPM and treatment response in 41 patients with TLE. The clinical characteristics, effective rate, retention rate and side effect of TPM were compared in TLE with and without FS. Results No difference was found in sex ratio, age, onset age, birth abnormality between the two groups, but the incidences of familial histories of epilepsy were different. There were no significant differences between TLE with FS group and without FS group in the ratios of TPM effectiveness, the ratios of one year seizure-free, the incidences of adverse event of TPM, three-month retention rate, six-month retention rate and one-year retention rate. Conclusion The association between TLE and FS still need researching. Topiramate is a relative safe and effective drug to treat TLE.
Objective To compare the clinical features and topiramate(TPM) efficacy of temporal lobe epilepsy(TLE)with and without febrile seizures(FS). Methods The clinical data were collected, including age,gender,history of epilepsy,history of febrile seizures,electroencephalograms, brain magnetic resonance imaging(MRI),dose of TPM and treatment response in 41 patients with TLE. The clinical characteristics, effective rate, retention rate and side effect of TPM were compared in TLE with and without FS. Results No difference was found in sex ratio, age, onset age, birth abnormality between the two groups, but the incidences of familial histories of epilepsy were different. There were no significant differences between TLE with FS group and without FS group in the ratios of TPM effectiveness, the ratios of one year seizure-free, the incidences of adverse event of TPM, three-month retention rate, six-month retention rate and one-year retention rate. Conclusion The association between TLE and FS still need researching. Topiramate is a relative safe and effective drug to treat TLE.
引文
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刘超,汤斌,曾杨,等.In-Fusion技术构建Ⅰ型钠通道与红色荧光蛋白共表达载体及其突变载体[J].实用医学杂志,2011,21(11):1908-1910.
Engel J Jr,International League Against Epilepsy(ILAE).Aproposed diagnostic scheme for people with epileptic seizuresand with epilepsy:report of the ILAE Task Force onClassification and Terminology[J].Epilepsia,2001,42(6):796-803.
Trinka E,Unterrainer J,Haberlandt E,et al.Childhoodfebrile convulsions-which factors determine the subsequentepilepsy syndrome?A retrospective study[J].Epilepsy Res,2002,50(3):283-292.
Hamati-Haddad A,Abou-Khalil B.Epilepsy diagnosis andlocalization in patients with antecedent childhood febrileconvulsions[J].Neurology,1998,50(4):917-922.
MacDonald B K,Johnson A L,Sandera J W,et al.Febrileconvulsions in220children-neurological sequelae at12yearsfollow-up[J].Euro Neurol,1999,41(4):179-186.
Liao W P,Shi Y W,Long Y S,et al.Partial epilepsy withantecedent febrile seizures and aggravation by antiepileptic drugs:Associated with loss of function of Nav1.1[J].Epilepsia,2010,51(9):1669-1678.
Giannakodimos S T,Georgiadis G,Tsounis S T,et al.Add-on topiramate in the treatment of refractory partial-onsetepilepsy:clinical experience of outpatient epilepsy clinics from11general hospitals[J].Seizure,2005,14(6):369-402.
魏大萍,陈峰,雷雪,等.托吡酯对难治性癫痫基础药物治疗的增效作用观察[J].实用医学杂志,2010,7(1):61-62.
Yang-Je Cho,Kyoung Heo,Won-Joo Kim,et al.Long-termefficacy and tolerability of topiramate as add-on therapy inrefractory partial epilepsy:An observational study[J].Epilepsia,2009,50(8):1910-1919.
Chrysostomos P,Panayiotopoulos.癫痫——发作和综合征的诊断和治疗[M].北京:中国协和医科大学出版社,2008:332-333.
刘超,汤斌,曾杨,等.In-Fusion技术构建Ⅰ型钠通道与红色荧光蛋白共表达载体及其突变载体[J].实用医学杂志,2011,21(11):1908-1910.
Engel J Jr,International League Against Epilepsy(ILAE).Aproposed diagnostic scheme for people with epileptic seizuresand with epilepsy:report of the ILAE Task Force onClassification and Terminology[J].Epilepsia,2001,42(6):796-803.
Trinka E,Unterrainer J,Haberlandt E,et al.Childhoodfebrile convulsions-which factors determine the subsequentepilepsy syndrome?A retrospective study[J].Epilepsy Res,2002,50(3):283-292.
Hamati-Haddad A,Abou-Khalil B.Epilepsy diagnosis andlocalization in patients with antecedent childhood febrileconvulsions[J].Neurology,1998,50(4):917-922.
MacDonald B K,Johnson A L,Sandera J W,et al.Febrileconvulsions in220children-neurological sequelae at12yearsfollow-up[J].Euro Neurol,1999,41(4):179-186.
Liao W P,Shi Y W,Long Y S,et al.Partial epilepsy withantecedent febrile seizures and aggravation by antiepileptic drugs:Associated with loss of function of Nav1.1[J].Epilepsia,2010,51(9):1669-1678.
Giannakodimos S T,Georgiadis G,Tsounis S T,et al.Add-on topiramate in the treatment of refractory partial-onsetepilepsy:clinical experience of outpatient epilepsy clinics from11general hospitals[J].Seizure,2005,14(6):369-402.
魏大萍,陈峰,雷雪,等.托吡酯对难治性癫痫基础药物治疗的增效作用观察[J].实用医学杂志,2010,7(1):61-62.
Yang-Je Cho,Kyoung Heo,Won-Joo Kim,et al.Long-termefficacy and tolerability of topiramate as add-on therapy inrefractory partial epilepsy:An observational study[J].Epilepsia,2009,50(8):1910-1919.