鱼油软胶囊对小鼠抗疲劳作用的实验研究
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摘要
本实验研究了鱼油软胶囊对小鼠的抗疲劳作用。结果表明:经口给予小鼠不同剂量的鱼油软胶囊30 d,高剂量(0.927 g/kg·BW)鱼油软胶囊能显著延长小鼠的负重游泳时间,低剂量(0.031 g/kg·BW)鱼油软胶囊和中剂量(0.309 g/kg·BW)鱼油软胶囊能显著提高肝糖原的储备量,同时能显著降低运动后血乳酸升高幅度,各剂量组对小鼠的体重增长、运动后血乳酸消除和运动后血清尿素氮水平均无明显影响。说明鱼油软胶囊具有抗疲劳作用。
The experiment of this study was to develop whether the fish oil soft capsule have the anti-fatigue effect on mice.The results showed that oral administration of mice in different doses of fish oil soft capsules for 30 days,fish oil saftcapsule with high dose(0.927 g/kg·BW)could extend the weight swimming time of mice,fish oil saft capsule with low dose(0.031 g/kg·BW)and medium dose(0.309 g/kg·BW)could increase the amount of muscle glycogen reserve,and reduce the increase in blood lactate after exercise;but all doses of fish oil soft capsule had no effect on weight gain in mice,after exercise serum Urea nitrogen levels and blood lactic acid elimination after exercise.Therefore,fish oil soft capsule had the function of anti-fatigue.
The experiment of this study was to develop whether the fish oil soft capsule have the anti-fatigue effect on mice.The results showed that oral administration of mice in different doses of fish oil soft capsules for 30 days,fish oil saftcapsule with high dose(0.927 g/kg·BW)could extend the weight swimming time of mice,fish oil saft capsule with low dose(0.031 g/kg·BW)and medium dose(0.309 g/kg·BW)could increase the amount of muscle glycogen reserve,and reduce the increase in blood lactate after exercise;but all doses of fish oil soft capsule had no effect on weight gain in mice,after exercise serum Urea nitrogen levels and blood lactic acid elimination after exercise.Therefore,fish oil soft capsule had the function of anti-fatigue.
引文
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[3]Burr M L.Fish and the cardiovascular system[J].Prog Food Nutri Sci,1989,13:291.
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[12]Louajri A,Harraga S,Godot V,et al.The effect of ginkgo biloba extract on free radical production in hypoxic rats[J].Biol Pharm Bull,2001,24(6):710-712.
[13]Sastre,Pallardo F V,Vina J.Mitochondrial oxidative stress plays a key role in aging and apoptosis[J].IUBM B Life,2000,49(5):427-435.
[14]李旭升,陈国荣,李剑敏,等.银杏叶提取物对大鼠心肌损伤的防护作用[J].中国应用生理学杂志,2005,21(2):176-178.
[15]谢伟,杨永亮,郑红英.银杏叶提取物对小鼠抗运动性疲劳能力影响的实验研究[J].2004,20(5):51-59.
[16]Walter M.Sphingolipids are required for mammalian epidermal barrier function[J].JClinInves,1991,88:1338-1345.
[17]Man Maoqiang,Feingold K R,Elias P M.Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis[J].Inves,1993,101(2):185-190.
[18]张祥沛.卵磷脂对小鼠耐力影响的实验研究[J].中国生化药物杂志,2001,22(2):89-90.
[2]Clemens V S,Seven F,Peter C W.Long-term effect of dietary marineω-3fatty-acid upon plasma and cellular lipid,platelet function and eicosanoid formation in human[J].J ClinInverst,1985,76:1626.
[3]Burr M L.Fish and the cardiovascular system[J].Prog Food Nutri Sci,1989,13:291.
[4]Das G.Fish oil in heart disease[J].Intern J ClinPharmacol,1989,27:569.
[5]Holub B J.Fish oil and cardiovascular disease[J].CMAJ,1989,141(15):1063.
[6]王建中,朱瑞龙,邱仁芳,等.鱼油多不饱和脂肪酸对人血小板、红细胞必需脂肪酸组成以及过氧化-抗氧化能力的影响[J].中国医药工业杂志,1992,23(2):74.
[7]Singh G,Chandra R K.Biochemical and cellular effects of fish oil and fish oils[J].Prog Food Nutri Sci,1988,12:371.
[8]李丹红,孟玉彩,赵文.红景天植物生物活性研究进展[J].毒理学杂志,2008,22(4):320-323.
[9]李浩.藏药红景天药理学研究进展[J].海峡药学,2008,20(10):5-7.
[10]陈亚东,曹秀兰,田长有,等.高山红景天对小鼠耐缺氧、抗疲劳及耐低温作用的影响[J].中国中医药科技,2002,9(3):157-158.
[11]黄增艳,范书铎.库页红景天对鼠抗疲劳作用机理的实验研究[J].中国医科大学学报,1998,27(2):123-124.
[12]Louajri A,Harraga S,Godot V,et al.The effect of ginkgo biloba extract on free radical production in hypoxic rats[J].Biol Pharm Bull,2001,24(6):710-712.
[13]Sastre,Pallardo F V,Vina J.Mitochondrial oxidative stress plays a key role in aging and apoptosis[J].IUBM B Life,2000,49(5):427-435.
[14]李旭升,陈国荣,李剑敏,等.银杏叶提取物对大鼠心肌损伤的防护作用[J].中国应用生理学杂志,2005,21(2):176-178.
[15]谢伟,杨永亮,郑红英.银杏叶提取物对小鼠抗运动性疲劳能力影响的实验研究[J].2004,20(5):51-59.
[16]Walter M.Sphingolipids are required for mammalian epidermal barrier function[J].JClinInves,1991,88:1338-1345.
[17]Man Maoqiang,Feingold K R,Elias P M.Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis[J].Inves,1993,101(2):185-190.
[18]张祥沛.卵磷脂对小鼠耐力影响的实验研究[J].中国生化药物杂志,2001,22(2):89-90.