甲基苯丙胺所致精神障碍的相关因素分析
|
摘要
目的:探讨影响甲基苯丙胺所致精神障碍的病程和症状严重程度的可能因素。方法:采用回顾性研究方法,中了解人口学信息、甲基苯丙胺使用情况及简明精神病评定量表(BPRS)评分,共61例患者纳入分析,使用多元线性回归(进入法)进行统计分析。结果:精神障碍病程与甲基苯丙胺使用时间正相关(B=2. 422,P=0. 002),BPRS总分与开始使用毒品的年龄负相关(B=-0. 493,P=0. 028)。结论:甲基苯丙胺滥用时间、开始使用甲基苯丙胺的年龄可以作为甲基苯丙胺所致精神障碍严重程度的预测因素。
Objective: The objective of this study was to determine the correlated factor of methamphetamine-induced psychosis( MIP) in patients with methamphetamine( MA) dependence.Methods: By adopting the method of retrospective study,general demographic and clinical data were collected from medical records when patients were admitted to Shenzhen Kangning Hospital. Brief Psychiatric Rating Scale( BPRS) scores were collected from medical records. 61 patients were included to the analysis. All the data were analyzed by multivariable linear regression( enter).Results: The duration of MIP was positively correlated with periods of MA exposure( B = 2. 422,P = 0. 002). BPRS total score was negatively correlated with age of onset of MA use( B =-0. 493,P = 0. 028).Conclusion: The longer period exposure of MA predicts the longer that psychosis is likely to last. The earlier one start to abuse MA the more severe MIP symptoms they produced.
Objective: The objective of this study was to determine the correlated factor of methamphetamine-induced psychosis( MIP) in patients with methamphetamine( MA) dependence.Methods: By adopting the method of retrospective study,general demographic and clinical data were collected from medical records when patients were admitted to Shenzhen Kangning Hospital. Brief Psychiatric Rating Scale( BPRS) scores were collected from medical records. 61 patients were included to the analysis. All the data were analyzed by multivariable linear regression( enter).Results: The duration of MIP was positively correlated with periods of MA exposure( B = 2. 422,P = 0. 002). BPRS total score was negatively correlated with age of onset of MA use( B =-0. 493,P = 0. 028).Conclusion: The longer period exposure of MA predicts the longer that psychosis is likely to last. The earlier one start to abuse MA the more severe MIP symptoms they produced.
引文
[1]郝柳,罗涛,唐爱国等.甲基苯丙胺滥用的研究进展[J].中国药物滥用防治杂志,2015,21(5):302-306.
[2]赵敏,郝伟.苯丙胺类兴奋剂所致精神障碍的临床诊治问题[J].上海精神医学,2011,23(6):324-328.
[3]Sato M. A lasting vulnerability to psychosis in patients with previous methamphetamine psychosis[J]. Ann N Y Acad Sci,1992,654:160-170.
[4]杨传青,王周然,孔志,等. 58例甲基苯丙胺成瘾患者临床特征分析[J].齐齐哈尔医学院学报,2017,38(24):2879-2880.
[5]Salo R,Nordahl TE,Leamon MH,et al. Preliminary evidence of behavioral predictors of recurrent drug-induced psychosis in methamphetamine abuse[J]. Psychiatry Res,2008,157(1-3):273-277.
[6]Russell K,Dryden DM,Liang Y,et al. Risk factors for methamphetamine use in youth:a systematic review[J]. BMC Pediatr,2008,8:48.
[7]Ahmad HS,Mas AS,Mohd HH,et al. The risk and associated factors of methamphetamine psychosis in methamphetaminedependent patients in Malaysia[J]. Comprehen Psych,2014,55:89-94.
[8]Rasmon K,Apiwat M,Viroj V et al. Risk factors for methamphetamine-induced paranoia and latency of symptom onset in a Thai drug treatment cohort[J]. Asian Biomed,2009,3(6):635-643.
[9]Chen CK,Lin SK,Sham PC,et al. Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis[J]. Psychol Med,2003,33(8):1407-1414.
[10]Ujike H,Sato M. Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis[J]. Ann N Y Acad Sci,2004,1025:279-287.
[11]Iwanami A,Sugiyama A,Kuroki N,et al. Patients with methamphetamine psychosis admitted to a psychiatric hospital in Japan.A preliminary report[J]. Acta Psychiatr Scand,1994,89(6):428-432.
[12]Akiyama K. Longitudinal clinical course following pharmacological treatment of methamphetamine psychosis which persists after long-term abstinence[J]. Ann N Y Acad Sci,2006,1074:125-134.
[13]Salo R,Nordahl TE,Buonocore MH,et al. Cognitive control and white matter callosal microstructure in methamphetaminedependent subjects:a diffusion tensor imaging study[J]. Biol Psychiatry,2009,65(2):122-128.
[2]赵敏,郝伟.苯丙胺类兴奋剂所致精神障碍的临床诊治问题[J].上海精神医学,2011,23(6):324-328.
[3]Sato M. A lasting vulnerability to psychosis in patients with previous methamphetamine psychosis[J]. Ann N Y Acad Sci,1992,654:160-170.
[4]杨传青,王周然,孔志,等. 58例甲基苯丙胺成瘾患者临床特征分析[J].齐齐哈尔医学院学报,2017,38(24):2879-2880.
[5]Salo R,Nordahl TE,Leamon MH,et al. Preliminary evidence of behavioral predictors of recurrent drug-induced psychosis in methamphetamine abuse[J]. Psychiatry Res,2008,157(1-3):273-277.
[6]Russell K,Dryden DM,Liang Y,et al. Risk factors for methamphetamine use in youth:a systematic review[J]. BMC Pediatr,2008,8:48.
[7]Ahmad HS,Mas AS,Mohd HH,et al. The risk and associated factors of methamphetamine psychosis in methamphetaminedependent patients in Malaysia[J]. Comprehen Psych,2014,55:89-94.
[8]Rasmon K,Apiwat M,Viroj V et al. Risk factors for methamphetamine-induced paranoia and latency of symptom onset in a Thai drug treatment cohort[J]. Asian Biomed,2009,3(6):635-643.
[9]Chen CK,Lin SK,Sham PC,et al. Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis[J]. Psychol Med,2003,33(8):1407-1414.
[10]Ujike H,Sato M. Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis[J]. Ann N Y Acad Sci,2004,1025:279-287.
[11]Iwanami A,Sugiyama A,Kuroki N,et al. Patients with methamphetamine psychosis admitted to a psychiatric hospital in Japan.A preliminary report[J]. Acta Psychiatr Scand,1994,89(6):428-432.
[12]Akiyama K. Longitudinal clinical course following pharmacological treatment of methamphetamine psychosis which persists after long-term abstinence[J]. Ann N Y Acad Sci,2006,1074:125-134.
[13]Salo R,Nordahl TE,Buonocore MH,et al. Cognitive control and white matter callosal microstructure in methamphetaminedependent subjects:a diffusion tensor imaging study[J]. Biol Psychiatry,2009,65(2):122-128.