益阳汤结合益生菌及美沙拉嗪治疗溃疡性肠炎的临床分析
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摘要
目的观察益阳汤结合益生菌、美沙拉嗪治疗溃疡性肠炎的临床疗效。方法对我院2015年8月~2016年10月期间所收治的136例溃疡性肠炎患者的临床资料进行回顾性分析,按照患者治疗方式的不同将其分为研究组与对照组,每组68例,对照组患者应用美沙拉嗪与益生菌联合治疗,研究组在此基础上加用益阳汤治疗,对比分析两组患者的临床疗效、用药时间、症状消失时间和不良反应发生情况,并对两组患者的炎症因子水平进行比较。结果研究组患者的临床总有效率(94.12%)明显高于对照组(82.35%),不良反应发生率(4.41%)低于对照组(20.59%),研究组治疗后的各项炎症因子水平也均优于对照组,且研究组用药时间[(9.52±2.18)d]与症状消失时间[(5.01±1.12)d]均短于对照组[(14.89±2.03)d、(9.23±1.56)d],差异有统计学意义(P<0.05)。结论益阳汤结合益生菌、美沙拉嗪治疗溃疡性肠炎的临床效果远高于单纯应用西药治疗的效果,中西医结合治疗手段能够有效改善患者的临床症状,缩短患者的用药时间,且具有不良反应少的优势,值得临床应用。
Objective To observe the clinical efficacy of Yiyang decoction combined with probiotics and mesalazine in the treatment of ulcerative colitis. Methods The clinical data of 136 patients with ulcerative colitis admitted from August 2015 to October 2016 in our hospital were retrospectively analyzed. The patients were divided into study group and control group according to the different treatment methods, with 68 cases in each group.The control group was treated with mesalazine combined with probiotics. The study group was treated with Yiyang decoction based on the above treatment. The clinical efficacy, medication time, symptoms disappear time and adverse reactions between the two groups were comparative analyzed. The levels of inflammatory cytokines were compared between the two groups.Results The clinical total effective rate(94.12%) in the study group was significantly higher than that in the control group(82.35%), and the incidence of adverse reactions(4.41%) in the study group was lower than that in the control group(20.59%). The levels of inflammatory factors[(9.52±2.18)d] in the study group were better than those of the control group.And the medication time[(9.52±2.18)d] and symptom disappearance time[(5.01±1.12) d] in the study group were both shorter than those in the control group[(14.89 ±2.03) d,(9.23±1.56) d], the differences were statistically significant(P <0.05). Conclusion The effect of Yiyang decoction combined with probiotics, mesalazine in the treatment of ulcerative colitis is much higher than that of the simple application of western medicine. The combination of traditional Chinese and western medicine treatment can effectively improve the patient's clinical symptoms, shorten the patient's medication time, and with the advantage of fewer adverse reactions, which is worthy of clinical application.
Objective To observe the clinical efficacy of Yiyang decoction combined with probiotics and mesalazine in the treatment of ulcerative colitis. Methods The clinical data of 136 patients with ulcerative colitis admitted from August 2015 to October 2016 in our hospital were retrospectively analyzed. The patients were divided into study group and control group according to the different treatment methods, with 68 cases in each group.The control group was treated with mesalazine combined with probiotics. The study group was treated with Yiyang decoction based on the above treatment. The clinical efficacy, medication time, symptoms disappear time and adverse reactions between the two groups were comparative analyzed. The levels of inflammatory cytokines were compared between the two groups.Results The clinical total effective rate(94.12%) in the study group was significantly higher than that in the control group(82.35%), and the incidence of adverse reactions(4.41%) in the study group was lower than that in the control group(20.59%). The levels of inflammatory factors[(9.52±2.18)d] in the study group were better than those of the control group.And the medication time[(9.52±2.18)d] and symptom disappearance time[(5.01±1.12) d] in the study group were both shorter than those in the control group[(14.89 ±2.03) d,(9.23±1.56) d], the differences were statistically significant(P <0.05). Conclusion The effect of Yiyang decoction combined with probiotics, mesalazine in the treatment of ulcerative colitis is much higher than that of the simple application of western medicine. The combination of traditional Chinese and western medicine treatment can effectively improve the patient's clinical symptoms, shorten the patient's medication time, and with the advantage of fewer adverse reactions, which is worthy of clinical application.
引文
[1]邢娟,王力.美沙拉嗪联合培菲康治疗溃疡性结肠炎的疗效分析[J].中国现代医生,2015,53(24):31-33.
[2]王澍琴,王学玲,王岚,等.地衣芽孢杆菌联合美沙拉嗪治疗溃疡性结肠炎的疗效及其对血清IL-17、IL-23、TNF-α的影响[J].中国现代医生,2017,55(23):13-16.
[3]黄朝玲,夏宣平,郭旭日,等.能全力在溃疡性结肠炎患者中的营养支持的应用研究[J].中国现代医生,2016,54(16):13-16.
[4]唐巧珍,刘玉兰.溃疡性结肠炎和肠易激综合征结肠黏膜HBD-2、NF-k B、IL-6和IL-23的表达[J].中国现代医生,2013,51(22):42-44.
[5]潘燕,欧阳钦.八味锡类散灌肠对溃疡性结肠炎的治疗作用及其机制研究[J].中国中西医结合杂志,2014,34(1):27-30.
[6]罗世英,周乐,吕小华,等.白花蛇舌草总黄酮对实验性溃疡性结肠炎的作用及免疫学机制研究[J].中国中药杂志,2014,39(5):896-900.
[7]王龙,胡翠,王晶,等.溃疡性结肠炎患者尿s CD14水平的检测及临床分析[J].安徽医科大学学报,2017,52(8):1258-1260.
[8]张国荣.中西医结合治疗溃疡性结肠炎的临床研究[J].中国现代医生,2011,49(19):159-160.
[9]牛文元,张镁硒,赵青,等.感染性腹泻病和溃疡性结肠炎患儿血清IL-17的水平变化及意义[J].中国现代医生,2010,48(5):58-59.
[10]张德正.溃疡性结肠炎的临床治疗与分析[J].中国现代医生,2007,45(8):37,89.
[11]陈强妹.美沙拉嗪缓释颗粒对溃疡性结肠炎患者血清IL-6、TNF-α影响机制的研究[J].中国现代医生,2011,49(36):34-35.
[12]朱柏桂,陈中和,张梅,等.微生态制剂对溃疡性结肠炎的临床疗效探讨[J].中国现代医生,2013,51(8):38-39,42.
[13]吕飞,田书芳,卢光新,等.溃疡性结肠炎患者中神经肽Y的检测意义分析[J].中国实验诊断学,2017,21(6):967-970.
[14]焦建华,陆彩霞,孙怡燕,等.穴位强化埋线疗法联合口服美沙拉嗪治疗溃疡性结肠炎疗效观察[J].山东医药,2014,54(11):42-43.
[15]李婷珊,黄颖娴,杨茜湄,等.宏观微观辨证施膳对大肠湿热型溃疡性结肠炎患者的应用效果观察[J].广州中医药大学学报,2017,34(4):514-518.
[2]王澍琴,王学玲,王岚,等.地衣芽孢杆菌联合美沙拉嗪治疗溃疡性结肠炎的疗效及其对血清IL-17、IL-23、TNF-α的影响[J].中国现代医生,2017,55(23):13-16.
[3]黄朝玲,夏宣平,郭旭日,等.能全力在溃疡性结肠炎患者中的营养支持的应用研究[J].中国现代医生,2016,54(16):13-16.
[4]唐巧珍,刘玉兰.溃疡性结肠炎和肠易激综合征结肠黏膜HBD-2、NF-k B、IL-6和IL-23的表达[J].中国现代医生,2013,51(22):42-44.
[5]潘燕,欧阳钦.八味锡类散灌肠对溃疡性结肠炎的治疗作用及其机制研究[J].中国中西医结合杂志,2014,34(1):27-30.
[6]罗世英,周乐,吕小华,等.白花蛇舌草总黄酮对实验性溃疡性结肠炎的作用及免疫学机制研究[J].中国中药杂志,2014,39(5):896-900.
[7]王龙,胡翠,王晶,等.溃疡性结肠炎患者尿s CD14水平的检测及临床分析[J].安徽医科大学学报,2017,52(8):1258-1260.
[8]张国荣.中西医结合治疗溃疡性结肠炎的临床研究[J].中国现代医生,2011,49(19):159-160.
[9]牛文元,张镁硒,赵青,等.感染性腹泻病和溃疡性结肠炎患儿血清IL-17的水平变化及意义[J].中国现代医生,2010,48(5):58-59.
[10]张德正.溃疡性结肠炎的临床治疗与分析[J].中国现代医生,2007,45(8):37,89.
[11]陈强妹.美沙拉嗪缓释颗粒对溃疡性结肠炎患者血清IL-6、TNF-α影响机制的研究[J].中国现代医生,2011,49(36):34-35.
[12]朱柏桂,陈中和,张梅,等.微生态制剂对溃疡性结肠炎的临床疗效探讨[J].中国现代医生,2013,51(8):38-39,42.
[13]吕飞,田书芳,卢光新,等.溃疡性结肠炎患者中神经肽Y的检测意义分析[J].中国实验诊断学,2017,21(6):967-970.
[14]焦建华,陆彩霞,孙怡燕,等.穴位强化埋线疗法联合口服美沙拉嗪治疗溃疡性结肠炎疗效观察[J].山东医药,2014,54(11):42-43.
[15]李婷珊,黄颖娴,杨茜湄,等.宏观微观辨证施膳对大肠湿热型溃疡性结肠炎患者的应用效果观察[J].广州中医药大学学报,2017,34(4):514-518.