柴胡疏肝散抗抑郁化学成分和药理作用研究进展
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摘要
抑郁症为当前社会高发病,柴胡疏肝散能够疏肝解郁,在临床上广泛用于治疗抑郁症。本文主要归纳总结了柴胡疏肝散主要的抗抑郁化学成分,并从其对神经递质、细胞因子、神经细胞损伤信号通路、神经内分泌、氧化应激等多重作用诠释其作用机理,以期为柴胡疏肝散进一步的研究与应用提供理论参考。
Depression is one of the high-prevalence diseases in the modern society. The Chaihushugan San has the effect of Shuganjieyu and is widely used in the clinical treatment of depression. This review summarizes the main chemicals accounting for the antidepressant effect of Chaihushugan San as well as its possible underlying pharmacological mechanism of neurotransmitters, cytokines, signaling pathway of neurocyte injury, neurotrophic factors, neuroendocrine and oxidative stress. This work may provide a theoretical reference for the further research and application of Chaihushugan San.
Depression is one of the high-prevalence diseases in the modern society. The Chaihushugan San has the effect of Shuganjieyu and is widely used in the clinical treatment of depression. This review summarizes the main chemicals accounting for the antidepressant effect of Chaihushugan San as well as its possible underlying pharmacological mechanism of neurotransmitters, cytokines, signaling pathway of neurocyte injury, neurotrophic factors, neuroendocrine and oxidative stress. This work may provide a theoretical reference for the further research and application of Chaihushugan San.
引文
[1]冯殿伟.抑郁症治疗靶标及其药物研发进展.中国医院药学杂志,2018,38(4)∶443～449.
[2]任鹏,王林林,许飞虹,等.柴胡疏肝散醇提物的抗氧化活性.中国实验方剂学杂志,2014,20(10)∶161～164.
[3]吴丽,王丽丽,李伟,等.芍药苷和芍药内酯苷的抗抑郁作用与NO/cGMP信号转导通路的相关性.世界中医药,2018,13(7)∶1714～1717+1722.
[4]崔广智,金树梅.芍药苷对利血平诱导抑郁模型的影响.中国实验方剂学杂志,2012,18(22)∶272～274.
[5]Huang H,Zhao J,Jiang L,et al.Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress.Int J Clin Exp Med,2015,8(4)∶5103～5111.
[6]Donato F,Borges Filho C,Giacomeli R,et al.Evidence for the involvement of potassium channel inhibition in the antidepressant-like effects of hesperidin in the tail suspension test in mice.J MED Food,2015,7(18)∶818～823.
[7]Antunes M S,Jesse C R,Ruff J R,et al.Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.Eur J Pharmacol,2016,789∶411～420.
[8]Wu M,Zhang H W,Zhou C,et al.Identification of the chemical constituents in aqueous extract of Zhi-Qiao and evaluation of its antidepressant Effect.Molecules,2015,40(20)∶6925～6940.
[9]蔡莉,李荣,吴清清,等.橙皮苷对慢性应激抑郁模型大鼠行为学及HPA轴的影响.中国中药杂志,2013,38(2)∶229～233.
[10]刘健翔,方吟荃,魏峥曦,等.槲皮素与贯叶连翘提取物合用抗抑郁作用初步研究.浙江大学学报(医学版),2013,42(6)∶615～619.
[11]刘毅,蓝诺,刘莉,等.木犀草素对慢性不可预知性温和应激所致小鼠抑郁的改善作用.时珍国医国药,2013,24(6)∶1382～1384.
[12]董海影,张静艳,柏青杨,等.柴胡皂苷A对抑郁模型大鼠海马神经细胞凋亡的保护作用.中国老年学杂志,2015,35(7)∶1935～1937.
[13]Chen X Q,Chen S J,Liang W N,et al.Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress.Neurosci Lett,2018,662∶283～289.
[14]Li H Y,Zhao Y H,Zeng M J,et al.Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats:involvement of HPA axis and hippocampal neurogenesis.Psychopharmacology (Berl),2017,22(234)∶3385～3394.
[15]Liu Y M,Hu C Y,Shen J D,et al.Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression.Physiol Behav,2017,169∶184～188.
[16]Lenzi J,Rodrigues A F,Rós Ade S,et al.Ferulic acid chronic treatment exerts antidepressant-like effect:role of antioxidant defense system.Metab Brain Dis,2015,30(6)∶1453～1463.
[17]Zeni ALB,Camargo A,Dalmagro AP.Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice.Steroids,2017,125∶131～136.
[18]Can ? D,Turan N,Demir ?zkay ü,et al.Antidepressant-like effect of gallic acid in mice:dual involvement of serotonergic and catecholaminergic systems.Life Sci,2017,190∶110～117.
[19]张建军,王景霞,李伟,等.芍药内酯苷抗抑郁作用的实验研究.中药与临床,2011,2(6)∶35～37.
[20]Wang B,Lian Y J,Dong X,et al.Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.Behav Brain Res,2018,353∶250～257.
[21]刘英,徐爱军,田艳霞,等.柴胡疏肝散对抑郁症大鼠海马5-HT及5-HT1A表达的影响.河北北方学院学报(自然科学版),2013,29(5)∶65～67+70.
[22]马玉峰,王嘉麟,邢佳,等.柴胡疏肝散对肝气郁结证大鼠海马及下丘脑单胺类神经递质的影响.中西医结合心脑血管病杂志,2016,14(21)∶2494～2497.
[23]Terada K,Izumo N,Suzuki B,et al.Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades.Neurochem Int,2014,69∶9～13.
[24]Casarotto P C,Santos P C,Lucas G A,et al.BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs.Eur Neuropsychopharmacol,2015,25(6)∶913～922.
[25]Takano K,Yamasaki H,Kawabe K,et al.Imipramine induces brain-derived neurotrophic factor mRNA expression in cultured astrocytes.J Pharmacol Sci,2012,120(3)∶176～186.
[26]Lepack A E,Fuchikami M,Dwyer J M,et al.BDNF release is required for the behavioral actions of ketamine.Int J Neuropsychopharmacol,2015,18(1)∶1～6.
[27]邓颖,张春虎,张海男,等.柴胡疏肝散及其拆方对抑郁模型大鼠行为及海马、杏仁核、额叶BDNF及其受体TrkB的影响.中国中西医结合杂志,2011,31(10)∶1373～1378.
[28]Maes M.Evidence for an immune response in major depression:a review and hypothesis.Prog Neuropsychopharmacol Biol Psychiatry,1995,19(1)∶11～38.
[29]杨冬花,李家邦,郑爱华,等.肝气郁结证模型大鼠Th1/Th2细胞因子变化及柴胡疏肝散的干预作用.湖南中医学院学报,2003,(5)∶4～7.
[30]Qiu J,Hu S Y,Zhang C H,et al.The effect of Chaihu-Shugan-San and its components on the expression of ERK5 in the hippocampus of depressed rats.J Ethnopharmacol,2014,152(2)∶320～326.
[31]朱玉英,纪荣静,熊佩黎,等.抑郁症大鼠海马神经元凋亡率和自噬相关蛋白的改变.中国组织化学与细胞化学杂志,2013,22(6)∶471～474.
[32]王小雪,岳广欣,巫鑫辉,等.抑郁症海马神经可塑性改变及中药调控作用研究现状.辽宁中医药大学学报,2017,19(4)∶80～84.
[33]杜雅薇,王玉来,尹岭,等.柴胡疏肝散对肝郁证模型大鼠脑海马ERK及其磷酸化的影响.中华中医药学刊,2012,30(6)∶1367～1369+1455～1456.
[34]王素娥,胡随瑜,张春虎,等.柴胡疏肝散及其拆方对慢性应激抑郁大鼠模型海马组织ERK1/2 mRNA表达的影响(英文).中南大学学报(医学版),2011,36(2)∶93～100.
[35]Zhang X H,Han L R,Liu J,et al.Pharmacokinetic study of 7 compounds following oral administration of fructus aurantii to depressive rats.Front Pharmacol,2018,(9)∶131.
[36]Schloesser R J,Manji H K,Martinowich K.Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.Neuroreport,2009,20(6)∶553～557.
[37]樊蔚虹,禹方,姚建平.柴胡疏肝散对慢性应激抑郁模型大鼠海马调节HPA轴功能的影响.中国中医基础医学杂志,2015,21(1)∶50～52.
[38]沈建英,李生强,杨小婷,等.柴胡疏肝散对围绝经期综合征肝郁大鼠卵巢雌激素受体基因表达的影响.世界中西医结合杂志,2016,11(7)∶929～933.
[39]Moylan S,Berk M,Dean O M,et al.Oxidative & nitrosative stress in depression:why so much stress?.Neurosci Biobehav Rev,2014,45∶46～62.
[40]李书启,苏志恒,彭静波,等.中药复方柴胡疏肝散体内外抗氧化活性及其与抗抑郁作用的潜在关系(英文).中国天然药物,2010,8(5)∶353～361.
[41]吴金霞,贾红梅,于猛,等.柴胡疏肝散体外抗氧化活性成分与调控抑郁症相关酶的关联性分析.中国实验方剂学杂志,2018,24(12)∶74～80.
[42]Wang Y,Kasper L H.The role of microbiome in central nervous system disorders.Brain Behav Immun,,2014,38∶1～12.
[43]Park A J,Collins J,Blennerhassett P A,et al.Altered colonic function and microbiota profile in a mouse model of chronic depression.Neuroqastroenterol Motil,2013,25∶733～e575.
[44]Maes M,Kubera M,Leunis J C,et al.Increased IgA and IgM responses against gut commensals in chronic depression.J Affect Disord,2012,141∶55～62.
[45]黄水明,丘劲松.柴胡疏肝散灌肠治疗抑郁症临床研究.中国民间疗法,2017,25(5)∶32～33.
[2]任鹏,王林林,许飞虹,等.柴胡疏肝散醇提物的抗氧化活性.中国实验方剂学杂志,2014,20(10)∶161～164.
[3]吴丽,王丽丽,李伟,等.芍药苷和芍药内酯苷的抗抑郁作用与NO/cGMP信号转导通路的相关性.世界中医药,2018,13(7)∶1714～1717+1722.
[4]崔广智,金树梅.芍药苷对利血平诱导抑郁模型的影响.中国实验方剂学杂志,2012,18(22)∶272～274.
[5]Huang H,Zhao J,Jiang L,et al.Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress.Int J Clin Exp Med,2015,8(4)∶5103～5111.
[6]Donato F,Borges Filho C,Giacomeli R,et al.Evidence for the involvement of potassium channel inhibition in the antidepressant-like effects of hesperidin in the tail suspension test in mice.J MED Food,2015,7(18)∶818～823.
[7]Antunes M S,Jesse C R,Ruff J R,et al.Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.Eur J Pharmacol,2016,789∶411～420.
[8]Wu M,Zhang H W,Zhou C,et al.Identification of the chemical constituents in aqueous extract of Zhi-Qiao and evaluation of its antidepressant Effect.Molecules,2015,40(20)∶6925～6940.
[9]蔡莉,李荣,吴清清,等.橙皮苷对慢性应激抑郁模型大鼠行为学及HPA轴的影响.中国中药杂志,2013,38(2)∶229～233.
[10]刘健翔,方吟荃,魏峥曦,等.槲皮素与贯叶连翘提取物合用抗抑郁作用初步研究.浙江大学学报(医学版),2013,42(6)∶615～619.
[11]刘毅,蓝诺,刘莉,等.木犀草素对慢性不可预知性温和应激所致小鼠抑郁的改善作用.时珍国医国药,2013,24(6)∶1382～1384.
[12]董海影,张静艳,柏青杨,等.柴胡皂苷A对抑郁模型大鼠海马神经细胞凋亡的保护作用.中国老年学杂志,2015,35(7)∶1935～1937.
[13]Chen X Q,Chen S J,Liang W N,et al.Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress.Neurosci Lett,2018,662∶283～289.
[14]Li H Y,Zhao Y H,Zeng M J,et al.Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats:involvement of HPA axis and hippocampal neurogenesis.Psychopharmacology (Berl),2017,22(234)∶3385～3394.
[15]Liu Y M,Hu C Y,Shen J D,et al.Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression.Physiol Behav,2017,169∶184～188.
[16]Lenzi J,Rodrigues A F,Rós Ade S,et al.Ferulic acid chronic treatment exerts antidepressant-like effect:role of antioxidant defense system.Metab Brain Dis,2015,30(6)∶1453～1463.
[17]Zeni ALB,Camargo A,Dalmagro AP.Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice.Steroids,2017,125∶131～136.
[18]Can ? D,Turan N,Demir ?zkay ü,et al.Antidepressant-like effect of gallic acid in mice:dual involvement of serotonergic and catecholaminergic systems.Life Sci,2017,190∶110～117.
[19]张建军,王景霞,李伟,等.芍药内酯苷抗抑郁作用的实验研究.中药与临床,2011,2(6)∶35～37.
[20]Wang B,Lian Y J,Dong X,et al.Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.Behav Brain Res,2018,353∶250～257.
[21]刘英,徐爱军,田艳霞,等.柴胡疏肝散对抑郁症大鼠海马5-HT及5-HT1A表达的影响.河北北方学院学报(自然科学版),2013,29(5)∶65～67+70.
[22]马玉峰,王嘉麟,邢佳,等.柴胡疏肝散对肝气郁结证大鼠海马及下丘脑单胺类神经递质的影响.中西医结合心脑血管病杂志,2016,14(21)∶2494～2497.
[23]Terada K,Izumo N,Suzuki B,et al.Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades.Neurochem Int,2014,69∶9～13.
[24]Casarotto P C,Santos P C,Lucas G A,et al.BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs.Eur Neuropsychopharmacol,2015,25(6)∶913～922.
[25]Takano K,Yamasaki H,Kawabe K,et al.Imipramine induces brain-derived neurotrophic factor mRNA expression in cultured astrocytes.J Pharmacol Sci,2012,120(3)∶176～186.
[26]Lepack A E,Fuchikami M,Dwyer J M,et al.BDNF release is required for the behavioral actions of ketamine.Int J Neuropsychopharmacol,2015,18(1)∶1～6.
[27]邓颖,张春虎,张海男,等.柴胡疏肝散及其拆方对抑郁模型大鼠行为及海马、杏仁核、额叶BDNF及其受体TrkB的影响.中国中西医结合杂志,2011,31(10)∶1373～1378.
[28]Maes M.Evidence for an immune response in major depression:a review and hypothesis.Prog Neuropsychopharmacol Biol Psychiatry,1995,19(1)∶11～38.
[29]杨冬花,李家邦,郑爱华,等.肝气郁结证模型大鼠Th1/Th2细胞因子变化及柴胡疏肝散的干预作用.湖南中医学院学报,2003,(5)∶4～7.
[30]Qiu J,Hu S Y,Zhang C H,et al.The effect of Chaihu-Shugan-San and its components on the expression of ERK5 in the hippocampus of depressed rats.J Ethnopharmacol,2014,152(2)∶320～326.
[31]朱玉英,纪荣静,熊佩黎,等.抑郁症大鼠海马神经元凋亡率和自噬相关蛋白的改变.中国组织化学与细胞化学杂志,2013,22(6)∶471～474.
[32]王小雪,岳广欣,巫鑫辉,等.抑郁症海马神经可塑性改变及中药调控作用研究现状.辽宁中医药大学学报,2017,19(4)∶80～84.
[33]杜雅薇,王玉来,尹岭,等.柴胡疏肝散对肝郁证模型大鼠脑海马ERK及其磷酸化的影响.中华中医药学刊,2012,30(6)∶1367～1369+1455～1456.
[34]王素娥,胡随瑜,张春虎,等.柴胡疏肝散及其拆方对慢性应激抑郁大鼠模型海马组织ERK1/2 mRNA表达的影响(英文).中南大学学报(医学版),2011,36(2)∶93～100.
[35]Zhang X H,Han L R,Liu J,et al.Pharmacokinetic study of 7 compounds following oral administration of fructus aurantii to depressive rats.Front Pharmacol,2018,(9)∶131.
[36]Schloesser R J,Manji H K,Martinowich K.Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.Neuroreport,2009,20(6)∶553～557.
[37]樊蔚虹,禹方,姚建平.柴胡疏肝散对慢性应激抑郁模型大鼠海马调节HPA轴功能的影响.中国中医基础医学杂志,2015,21(1)∶50～52.
[38]沈建英,李生强,杨小婷,等.柴胡疏肝散对围绝经期综合征肝郁大鼠卵巢雌激素受体基因表达的影响.世界中西医结合杂志,2016,11(7)∶929～933.
[39]Moylan S,Berk M,Dean O M,et al.Oxidative & nitrosative stress in depression:why so much stress?.Neurosci Biobehav Rev,2014,45∶46～62.
[40]李书启,苏志恒,彭静波,等.中药复方柴胡疏肝散体内外抗氧化活性及其与抗抑郁作用的潜在关系(英文).中国天然药物,2010,8(5)∶353～361.
[41]吴金霞,贾红梅,于猛,等.柴胡疏肝散体外抗氧化活性成分与调控抑郁症相关酶的关联性分析.中国实验方剂学杂志,2018,24(12)∶74～80.
[42]Wang Y,Kasper L H.The role of microbiome in central nervous system disorders.Brain Behav Immun,,2014,38∶1～12.
[43]Park A J,Collins J,Blennerhassett P A,et al.Altered colonic function and microbiota profile in a mouse model of chronic depression.Neuroqastroenterol Motil,2013,25∶733～e575.
[44]Maes M,Kubera M,Leunis J C,et al.Increased IgA and IgM responses against gut commensals in chronic depression.J Affect Disord,2012,141∶55～62.
[45]黄水明,丘劲松.柴胡疏肝散灌肠治疗抑郁症临床研究.中国民间疗法,2017,25(5)∶32～33.