病机证素与代谢组学在缺血性中风病治疗中的应用研究概述
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摘要
缺血性中风为临床常见病,因其高发病率、高死亡率等临床特点在研究中备受重视。代谢组学在中医药临床上的应用为中西医学找到了共同的语言,成为中医证候实质研究的新热点与突破点,而中医基础研究的关键问题之一就是证候的研究。就近5年病机证素与代谢组学在缺血性中风病中的应用研究进行总结阐述,以期为缺血性中风病的中医病证研究及预防治疗提供新的思路与方法。参考文献31篇。
引文
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[30]邹忠杰,龚梦娟,谢媛媛,等.氢化可的松诱导的肾阳虚大鼠尿液代谢组学研究[J].中国实验方剂学杂志,2012,18(8):133-136.
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[32]石岩,吕晓东,庞立健,等.基于代谢组学的特发性肺纤维化中医证候学研究意义探索[J].中华中医药杂志,2016,31(1):17-19.
[2]周学平,叶放,郭立中,等.以病机为核心构建中医辨证论治新体系——国医大师周仲瑛教授学术思想探讨[J].中医杂志,2011,52(18):1531-1534.
[3]衡百川.运用证素理论探讨血脂异常的中医病机[D].郑州:河南中医学院,2014:56.
[4]过伟峰.基于病机研究出血性中风证候诊断方法[J].南京中医药大学学报,2013,29(1):1-4.
[5]刘贝,梁生旺.代谢组学在缺血性脑卒中研究中的进展[J].中国临床药理学与治疗学,2014,19(7):828-834.
[6]Iola F Duarte,Sílvia O Diaz,Ana M Gil.NMR metabolomics of human blood and urine in disease research[J].Journal of Pharmaceutical and Biomedical Analysis,2014,93(5):17-26.
[7]祝美珍,齐玉洁,曾石森,等.系统生物学模式下的中风病研究对策[J].中医杂志,2013,54(17):1460-1463.
[8]Mingxing Yang,Shu Wang,Fuhua Hao,et al.NMR analysis of the ratneurochemical changes induced by middle cerebralartery occlusion[J].Talanta,2012,88(15):136-144.
[9]Alcaraz-Contreras Y,Garza-Ocanas L,Ramírez-Gómez X S,et al.Effect of glycine on lead mobilization,lead-induced oxidative stress,and hepatic toxicity in rats[J].J.Toxicol,2011(7):1-7.
[10]Jung J Y,Lee H S,Kang D G,et al.1H-NMR-based metabolomics study of cerebral infarction[J].Stroke,2011,42(5):1282-1288.
[11]Mustonen P,Lehtonen K V,Javela K,et al.Persistent antiphospholipid antibody(a PL)in asymptomatic carriers as a risk factor for future thrombotic events:a nationwide prospective study[J].Lupus,2014,23:1468-1476.
[12]De Meyer S F,Stoll G,Wagner D D,et al.von Willebrandfactor:an emerging target in stroke therapy[J].Stroke,2012,43:599-606.
[13]Di Castelnuovo A,Agnoli C,De Curtis A,et al.Elevated levels of D-dimers increase the risk of ischaemic and haemorrhagic stroke:Findings from the EPICOR Study[J].Thromb Haemost,2014,112:941-946.
[14]涂佳玉,阿基业,王广基,等.通塞脉微丸干预缺血性脑中风模型大鼠的血浆代谢组学研究[J].中国中药杂志,2012,37(7):1028-1033.
[15]涂佳玉,阿基业,文红梅,等.通塞脉微丸干预缺血性脑中风大鼠的脑组织代谢组学研究[J].中国药理学通报,2011,27(10):1467-1471.
[16]万小莉,夏鑫华,戚欢阳,等.氨基酸代谢与缺血性脑中风的相关性研究[J].中药新药与临床药理,2013,24(6):588-592.
[17]万小莉,夏鑫华,刘梅,等.局灶性脑缺血模型大鼠脑内脂肪酸代谢与缺血性脑中风的相关性[J].广东医学,2014,35(24):3788-3791.
[18]夏鑫华,刘梅.基于代谢组学的补阳还五汤干预缺血性脑卒中的作用机制研究[J].中华中医药学刊,2014,32(7):1659-1662.
[19]Savitz S I,Schabitz,W R.Reviving neuroprotection using anew approach;targeting ostsynaptic density-95 to arrest glutamate excitotoxicity[J].Stroke,2012,43:3411-3412.
[20]Krisanova N,Sivko R,Kasatkina L,et al.Neuroprotection by lowering cholesterol:a decrease in membrane cholesterol content reduces transporter-mediated glutamate release from brain nerve terminals[J].Biochim Biophys Acta,2012,18(22):1553-1561.
[21]Bharosay A,Bharosay V V,Varma M,et al.Correlation of brain biomarker neuron specific enolase(NSE)with degree of disability and neurological worsening in cerebrovascular stroke[J].Indian J Clin Biochem,2012,27(2):186-190.
[22]Ghandforoush-Sattari M,Mashayekhi S O,Nemati M,et al.Changes in plasma concentration of taurine in stroke[J].Neuroscience Letters,2011,496(3):172-175.
[23]Pekun T G,Lemeshchenko V V,Lyskova T I,et al.Influence of intra-andextracellular acidification on free radical formation and mitochondria membranepotential in rat brain synaptosomes[J].J Mol Neurosci,2013,49(1):211-22.
[24]孙安会,袁肇凯,夏世靖,等.中医证候系统生物学研究的现状和展望[J].中华中医药杂志,2016,31(1):200-201.
[25]Cao H,Zhang A,Zhang H,et al.The application of metabolomics in traditional Chinese medicine opens up a dialogue between Chinese and western medicine.Phytotherapy Research,2015,29(2):159-166.
[26]徐琬梨,刘家义,张宁,等.多囊卵巢综合征痰湿证代谢组学方法研究趋势分析[C]//中国中西医结合学会第六届全国诊断学术会议论文集.贵阳:中国中西医结合学会,2012:160-164.
[27]徐琬梨,刘家义.代谢组学方法应用于多囊卵巢综合征痰湿证研究趋势分析[J].中国中医药科技,2014,1(21):59-61.
[28]杨宇峰,滕飞.气滞湿阻证代谢综合征大鼠血液代谢组学研究[J].时珍国医国药,2014,25(12):3075-3076.
[29]刘志刚,李泽庚,彭波.肺气虚型慢性阻塞性肺疾病大鼠模型及其中药干预的血浆代谢组学研究[J].中华中医药杂志,2013,28(3):793-797.
[30]邹忠杰,龚梦娟,谢媛媛,等.氢化可的松诱导的肾阳虚大鼠尿液代谢组学研究[J].中国实验方剂学杂志,2012,18(8):133-136.
[31]郑海生,蒋健,贾伟,等.慢性心力衰竭肾阳虚证患者代谢组学研究[J].中华中医药杂志,2015,2(2):198-201.
[32]石岩,吕晓东,庞立健,等.基于代谢组学的特发性肺纤维化中医证候学研究意义探索[J].中华中医药杂志,2016,31(1):17-19.