外泌体对低氧/缺血损伤脑神经的保护作用
|
摘要
低氧/缺血会对神经系统产生损伤,减轻低氧/缺血状态对脑神经损伤的至关重要的一个方面就是抑制氧自由基和炎性因子的产生,这也是目前治疗的一个重要策略。低氧/缺血预适应可以通过抑制氧自由基和炎性因子来保护神经细胞。低氧/缺血预适应刺激的外泌体的转运可能是保护作用机制之一,本文通过对外泌体在低氧/缺血状态下发挥的神经保护作用和作用机制等方面进行综述,为低氧/缺血脑神经保护的治疗研究提供新思路。
引文
1 Raposo G,Stoorvogel W.Extracellular vesicles:Exosomes,microvesicles,and friends.J Cell Biol,2013,200373~383.
2 Skotland T,Ekroos K,Kauhanen D,et al.Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers.Eur J Cancer,2017,70122~132.
3 Eduard W,Johansson H J,Imre M,et al.Cells release subpopulations of exosomes with distinct molecular and biological properties.Sci Rep,2016,622519.
4 Wang Y,Zhang L,Li Y,et al.Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium.Int J Cardiol,2015,19261~69.
5 Balusu S,Wonterghem EV,Rycke RD,et al.Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.Embo Mol Med,2016,81162~1183.
6 Yang T,Martin P,Fogarty B,et al.Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in danio rerio.Pharm Res,2015,322003~2014.
7 Xin H,Katakowski M,Wang F,et al.MicroRNA cluster miR-17-92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats.Stroke,2017,48747~753.
8 Hongqi X,Yi L,Michael C.Exosomes/miRNAs as mediating cell-based therapy of stroke.Front Cell Neurosci,2014,8377.
9 Kalani A,Chaturvedi P,Kamat P K,et al.Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury.Int J Biochem Cell B,2016,79360~369.
10 Lachenal G,Pernet-Gallay K,Chivet M,et al.Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity.Mol Cell Neurosci,2011,46409~418.
11 Charkson AN,Overmem JJ,Zhong S.AMPA receptor-induced local brain-parived neurotrophic factor signaling mediates mediates motor recovery after storke.J Neurosci,2011,313766~3775.
12 Xin H,Li Y,Cui Y,et al.Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats.J Cereb Blood Flow Metab,2013,331711~1715.
13 Gherardini L,Gennaro M,Pizzorusso T.Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats.Cereb Cortex,2013,25202~212.
14 Zhang Y,Chopp M,Liu X S,et al.MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and c GMP on axonal growth.Dev Neurobiol,2016,751402~1419.
15 Cantaluppi V,Biancone L,Figliolini F,et al.Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets.Cell Transplant,2012,211305~1320.
16 Yamamoto S,Niida S,Azuma E,et al.Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.SCI REP-UK,2015,58505~8514.
17 Schulz GB,Wieland E,Wüstehube-Lausch J,et al.Cerebral cavernous malformation-1 protein controls DLL4-notch3signaling between the endothelium and pericytes.Stroke,2015,461337~1347.
18 Guitart K,Loers G,Buck F,et al.Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein.Glia,2016,64896~910.
19 Jiang M,Wang H,Jin M,et al.Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced,autophagy-mediated brain injury by promoting M2 microglial/macrophage polarization.Cell Physiol Biochem,2018,47864~878.
20 Chiara Cossetti,Nunzio Iraci,Tim R.Mercer,et al.Extracellular vesicles from neural stem cells transfer IFN-γvia Ifngr1 to activate Stat1 signaling in target cells.Mol Cell,2014,56193~204.
21 Drommelschmidt K,Serdar M,Bendix I,et al.Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury.Brain Behav Immun,2017,60220.
22 Goncalves MB,Malmqvist T,Clarke E,et al.Neuronal RARβsignaling modulates PTEN activity directly in neurons and via exosome transfer in astrocytes to prevent glial scar formation and induce spinal cord regeneration.J Neurosci,2015,3515731~15745.
23 Zheng T,Pu J,Chen Y,et al.Plasma exosomes spread and cluster aroundβ-amyloid plaques in an animal model of Alzheimer's disease.Front Aging Neurosci,2017,91~12.
2 Skotland T,Ekroos K,Kauhanen D,et al.Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers.Eur J Cancer,2017,70122~132.
3 Eduard W,Johansson H J,Imre M,et al.Cells release subpopulations of exosomes with distinct molecular and biological properties.Sci Rep,2016,622519.
4 Wang Y,Zhang L,Li Y,et al.Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium.Int J Cardiol,2015,19261~69.
5 Balusu S,Wonterghem EV,Rycke RD,et al.Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.Embo Mol Med,2016,81162~1183.
6 Yang T,Martin P,Fogarty B,et al.Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in danio rerio.Pharm Res,2015,322003~2014.
7 Xin H,Katakowski M,Wang F,et al.MicroRNA cluster miR-17-92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats.Stroke,2017,48747~753.
8 Hongqi X,Yi L,Michael C.Exosomes/miRNAs as mediating cell-based therapy of stroke.Front Cell Neurosci,2014,8377.
9 Kalani A,Chaturvedi P,Kamat P K,et al.Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury.Int J Biochem Cell B,2016,79360~369.
10 Lachenal G,Pernet-Gallay K,Chivet M,et al.Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity.Mol Cell Neurosci,2011,46409~418.
11 Charkson AN,Overmem JJ,Zhong S.AMPA receptor-induced local brain-parived neurotrophic factor signaling mediates mediates motor recovery after storke.J Neurosci,2011,313766~3775.
12 Xin H,Li Y,Cui Y,et al.Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats.J Cereb Blood Flow Metab,2013,331711~1715.
13 Gherardini L,Gennaro M,Pizzorusso T.Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats.Cereb Cortex,2013,25202~212.
14 Zhang Y,Chopp M,Liu X S,et al.MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and c GMP on axonal growth.Dev Neurobiol,2016,751402~1419.
15 Cantaluppi V,Biancone L,Figliolini F,et al.Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets.Cell Transplant,2012,211305~1320.
16 Yamamoto S,Niida S,Azuma E,et al.Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.SCI REP-UK,2015,58505~8514.
17 Schulz GB,Wieland E,Wüstehube-Lausch J,et al.Cerebral cavernous malformation-1 protein controls DLL4-notch3signaling between the endothelium and pericytes.Stroke,2015,461337~1347.
18 Guitart K,Loers G,Buck F,et al.Improvement of neuronal cell survival by astrocyte-derived exosomes under hypoxic and ischemic conditions depends on prion protein.Glia,2016,64896~910.
19 Jiang M,Wang H,Jin M,et al.Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced,autophagy-mediated brain injury by promoting M2 microglial/macrophage polarization.Cell Physiol Biochem,2018,47864~878.
20 Chiara Cossetti,Nunzio Iraci,Tim R.Mercer,et al.Extracellular vesicles from neural stem cells transfer IFN-γvia Ifngr1 to activate Stat1 signaling in target cells.Mol Cell,2014,56193~204.
21 Drommelschmidt K,Serdar M,Bendix I,et al.Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury.Brain Behav Immun,2017,60220.
22 Goncalves MB,Malmqvist T,Clarke E,et al.Neuronal RARβsignaling modulates PTEN activity directly in neurons and via exosome transfer in astrocytes to prevent glial scar formation and induce spinal cord regeneration.J Neurosci,2015,3515731~15745.
23 Zheng T,Pu J,Chen Y,et al.Plasma exosomes spread and cluster aroundβ-amyloid plaques in an animal model of Alzheimer's disease.Front Aging Neurosci,2017,91~12.