正畸治疗中应用二膦酸盐对牙根吸收及牙移动的影响
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摘要
目的:探讨正畸治疗中应用二膦酸盐对牙根吸收及牙移动的影响。方法:选取2014年8月—2016年8月我院收治的牙根发育不良的患者120例,根据治疗方法不同分成两组,各60例。对照组应用正畸治疗,研究组在对照组基础上联合二膦酸盐(戴上矫正器前在上颌中腭侧黏骨膜的地方注射二膦酸盐50μL,隔三天注射一次)治疗,比较两组牙根吸收值、治疗前后牙根吸收程度的分布以及治疗后不同时刻牙移动距离。结果:治疗后第4,8,12天,研究组牙根吸收值显著低于对照组,差异有统计学意义(P <0.05);治疗后研究组牙根吸收程度分布0级占比显著高于对照组,1级、2级、3级、4级占比低于对照组,差异有统计学意义(P <0.05);治疗后第4,8,12天研究组牙移动距离均显著小于对照组,差异有统计学意义(P <0.05)。结论:正畸治疗中应用二膦酸盐有助于降低牙根吸收的程度,减少牙移动,改善正畸治疗的效果,值得临床推广应用。
Objective: To investigate the effect of bisphosphonate on root resorption and tooth movement in orthodontic treatment. Methods: 120 patients with root dysplasia admitted to our hospital from August 2014 to August 2016 were selected and divided into two groups according to different treatment methods, 60 cases each. The patients in the control group were given orthodontic treatment, and the patients in the study group were treated with bisphosphonate(injection of bisphosphonate 50 μL at the maxillary medial palate mucoperiosteum before putting on orthotic appliance, once every three days). The value of root resorption, the distribution of root resorption degree before and after treatment and the distance of tooth movement at different time points after treatment were compared between the two groups. Results: On the 4 th, 8 th and 12 th day after treatment, the value of root resorption in the study group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The proportion of root resorption degree distribution grade 0 in the study group after treatment was significantly higher than that in the control group, and the proportions of grade 1, grade 2, grade 3 and grade 4 in the study group were lower than those in the control group, with statistically significant differences(P<0.05). The distance of tooth movement on the 4 th, 8 th and 12 th day after treatment in the study group was significantly smaller than that in the control group, and the differences were statistically significant(P<0.05). Conclusion: The application of bisphosphonate in orthodontic treatment can help reduce the degree of root resorption, reduce tooth movement and improve the effect of orthodontic treatment, which is worthy of clinical application.
Objective: To investigate the effect of bisphosphonate on root resorption and tooth movement in orthodontic treatment. Methods: 120 patients with root dysplasia admitted to our hospital from August 2014 to August 2016 were selected and divided into two groups according to different treatment methods, 60 cases each. The patients in the control group were given orthodontic treatment, and the patients in the study group were treated with bisphosphonate(injection of bisphosphonate 50 μL at the maxillary medial palate mucoperiosteum before putting on orthotic appliance, once every three days). The value of root resorption, the distribution of root resorption degree before and after treatment and the distance of tooth movement at different time points after treatment were compared between the two groups. Results: On the 4 th, 8 th and 12 th day after treatment, the value of root resorption in the study group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The proportion of root resorption degree distribution grade 0 in the study group after treatment was significantly higher than that in the control group, and the proportions of grade 1, grade 2, grade 3 and grade 4 in the study group were lower than those in the control group, with statistically significant differences(P<0.05). The distance of tooth movement on the 4 th, 8 th and 12 th day after treatment in the study group was significantly smaller than that in the control group, and the differences were statistically significant(P<0.05). Conclusion: The application of bisphosphonate in orthodontic treatment can help reduce the degree of root resorption, reduce tooth movement and improve the effect of orthodontic treatment, which is worthy of clinical application.
引文
[1]邹亚楠,林聪,王旭霞,等.两种二膦酸盐对大鼠正畸源性牙根吸收及牙移动影响的对比研究[J].口腔医学,2017,37(10):865-870.
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[5]崔跃,姜欢,胡敏.破骨细胞蛋白酪氨酸磷酸酶与正畸移动牙牙根吸收的关系[J].国际口腔医学杂志,2017,44(1):87-91.
[6]余彦衡,黄昕艳,郑嵘,等.肾虚及正常大鼠的正畸致牙根吸收易感性比较及组织内白细胞介素17的表达差异[J].中国组织工程研究,2016,20(51):7703-7709.
[7]卢安喜.胸腔镜下肺叶切除术联合氨溴索治疗肺癌对其血清中IL-6水平及外周血淋巴细胞免疫活性的影响[J].中国合理用药探索,2017,14(11):44-46.
[8]林燕,江银华,陶海彪,等.上颌埋伏中切牙正畸治疗前、后体积和表面积变化的锥形束CT分析[J].上海口腔医学,2017,26(1):76-79.
[9]Seifi M,Kazemi B,Kabiri S,et al.Analysis of Transforming Growth Factor-β1 Expression in Resorptive Lacunae following Orthodontic Tooth Movement in An Animal Model[J].Cell J,2017,19(2):278-282.
[10]夏文倩,顾永佳,高美琴.安氏Ⅱ类1分类和2分类错(牙合)畸形患者上中切牙区牙槽骨的三维形态分析[J].上海口腔医学,2016,25(1):68-71.
[11]马艳,鲍玮玮,张娟,等.骨性Ⅲ类错颌正畸治疗前行改良骨皮质切开术对矢状方向上牙齿移动模式的影响[J].医学综述,2016,22(10):2048-2050.
[12]Castro I,Valladares-Neto J,Estrela C.Contribution of cone beam computed tomography to the detection of apical root resorption after orthodontic treatment in root-filled and vital teeth[J].Angle Orthod,2015,85(5):771-776.
[2]吴佳琪,江久汇,徐莉,等.术前正畸中改良骨皮质切开术对牙槽骨及牙根影响的锥形束CT观察[J].中华口腔医学杂志,2015,50(4):223-227.
[3]Hikida T,Yamaguchi M,Shimizu M,et al.Comparisons of orthodontic root resorption under heavy and jiggling reciprocating forces during experimental tooth movement in a rat model[J].Korean J Orthod,2016,46(4):228-241.
[4]刘红,卢军,张真,等.MMP-2和TIMP-2参与大鼠实验性正畸牙齿移动及牙根吸收机制的研究[J].牙体牙髓牙周病学杂志,2017,27(7):382-386.
[5]崔跃,姜欢,胡敏.破骨细胞蛋白酪氨酸磷酸酶与正畸移动牙牙根吸收的关系[J].国际口腔医学杂志,2017,44(1):87-91.
[6]余彦衡,黄昕艳,郑嵘,等.肾虚及正常大鼠的正畸致牙根吸收易感性比较及组织内白细胞介素17的表达差异[J].中国组织工程研究,2016,20(51):7703-7709.
[7]卢安喜.胸腔镜下肺叶切除术联合氨溴索治疗肺癌对其血清中IL-6水平及外周血淋巴细胞免疫活性的影响[J].中国合理用药探索,2017,14(11):44-46.
[8]林燕,江银华,陶海彪,等.上颌埋伏中切牙正畸治疗前、后体积和表面积变化的锥形束CT分析[J].上海口腔医学,2017,26(1):76-79.
[9]Seifi M,Kazemi B,Kabiri S,et al.Analysis of Transforming Growth Factor-β1 Expression in Resorptive Lacunae following Orthodontic Tooth Movement in An Animal Model[J].Cell J,2017,19(2):278-282.
[10]夏文倩,顾永佳,高美琴.安氏Ⅱ类1分类和2分类错(牙合)畸形患者上中切牙区牙槽骨的三维形态分析[J].上海口腔医学,2016,25(1):68-71.
[11]马艳,鲍玮玮,张娟,等.骨性Ⅲ类错颌正畸治疗前行改良骨皮质切开术对矢状方向上牙齿移动模式的影响[J].医学综述,2016,22(10):2048-2050.
[12]Castro I,Valladares-Neto J,Estrela C.Contribution of cone beam computed tomography to the detection of apical root resorption after orthodontic treatment in root-filled and vital teeth[J].Angle Orthod,2015,85(5):771-776.