蝙蝠葛碱对阿尔茨海默病小鼠海马组织Aβ水平的影响
|
摘要
目的:研究中药提纯成分蝙蝠葛碱对阿尔茨海默病小鼠海马组织Aβ水平的影响。方法:阿尔茨海默病小鼠随机分成对照组、模型组、治疗组、蝙蝠葛碱组。给予蝙蝠葛碱灌胃,观察小鼠Aβ的变化。结果:与模型组比较后,蝙蝠葛碱组Aβ水平明显降低。结论:蝙蝠葛碱能降低Aβ水平,对阿尔茨海默病小鼠具有一定的海马组织保护作用。
引文
[1]何丽娅,李立中,吴基良.蝙蝠葛碱的抗氧化实验研究[J].中草药,1997,28(8):479-481.
[2]李艳红,黄向江,卢浩浩.蝙蝠葛碱对大鼠局灶性脑缺血及线粒体氧化损伤的保护作用[J].华中科技大学学报(医学版),2005,34(3):270-273.
[3]李艳红,龚培力.蝙蝠葛碱对实验小鼠脑缺血的保护作用[J].中国药理学通报,2004,20(5):564-567.
[4]Wu Y L,Xin X J,Xin X L,et al.Research progress about the regulation of GXXXG structures in the Alzheimer-related protein[J].Chin Pharmacol Bull,2011,27(1):1-4.
[5]Mohandas E,Rajmohan V,Raghunath B.Neurobiology of Alzheimer's disease[J].Indian Journal of Psychiatry.2009,51(1):55-61.
[6]Rossi L,Mazzitelli S,Arciello M,et al.Benefits from dietary polyphenols for brain aging and Alzheimer's disease[J].Neurochem Res,2008,33(12):2390-2400.
[2]李艳红,黄向江,卢浩浩.蝙蝠葛碱对大鼠局灶性脑缺血及线粒体氧化损伤的保护作用[J].华中科技大学学报(医学版),2005,34(3):270-273.
[3]李艳红,龚培力.蝙蝠葛碱对实验小鼠脑缺血的保护作用[J].中国药理学通报,2004,20(5):564-567.
[4]Wu Y L,Xin X J,Xin X L,et al.Research progress about the regulation of GXXXG structures in the Alzheimer-related protein[J].Chin Pharmacol Bull,2011,27(1):1-4.
[5]Mohandas E,Rajmohan V,Raghunath B.Neurobiology of Alzheimer's disease[J].Indian Journal of Psychiatry.2009,51(1):55-61.
[6]Rossi L,Mazzitelli S,Arciello M,et al.Benefits from dietary polyphenols for brain aging and Alzheimer's disease[J].Neurochem Res,2008,33(12):2390-2400.