蝙蝠葛碱对阿尔茨海默病小鼠脑组织形态学的影响
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摘要
为了探讨蝙蝠葛碱对阿尔茨海默病小鼠脑组织的作用,选择阿尔茨海默病小鼠,随机分成对照组、模型组、治疗组、蝙蝠葛碱组,给予蝙蝠葛碱灌胃治疗后处死小鼠,观察小鼠脑组织形态结构,结果表明,与对照组比较,模型组小鼠神经元数量减少并且变性,与模型组比较,蝙蝠葛碱组神经元形态改善明显,从而得出蝙蝠葛碱可以维持阿尔茨海默病小鼠脑组织神经元正常的组织结构的结论。
Objective: To get the effects of dauricine of brain tissues in Alzheimer's disease mice. Methods Alzheimer's disease male mice were randomly divided into control group,model group,treatment group,and dauricine group. After the treatment,all animals were sacrificed,morphology of brain tissues was observed. Results: Compared with the control group,the model group lost normal morphological structure of nerve cells and the number of nerve cells significantly decreased. Compared with the model group,the dauricine group of brain maintained normal morphological structure of nerve cells and the number of nerve cells significantly increased. Conclusion: Dauricine can maintain normal morphological structure of nerve cells of Alzheimer's disease mice.
Objective: To get the effects of dauricine of brain tissues in Alzheimer's disease mice. Methods Alzheimer's disease male mice were randomly divided into control group,model group,treatment group,and dauricine group. After the treatment,all animals were sacrificed,morphology of brain tissues was observed. Results: Compared with the control group,the model group lost normal morphological structure of nerve cells and the number of nerve cells significantly decreased. Compared with the model group,the dauricine group of brain maintained normal morphological structure of nerve cells and the number of nerve cells significantly increased. Conclusion: Dauricine can maintain normal morphological structure of nerve cells of Alzheimer's disease mice.
引文
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[6]李艳红,龚培力.蝙蝠葛碱对实验小鼠脑缺血的保护作用[J].中国药理学通报,2004,20(5):564—567.
[7]何胜,玉莹,陈菊芳,等.D-半乳糖加亚硝酸钠建立痴呆症小鼠模型和中药治疗的效果[J].中国老年学杂志,2014,34(2):422—424.
[8]周妍妍,刘艳丽,董春雪,等.五味子醇甲对APP/PS1双转基因痴呆模型小鼠脑组织突触素、α-突触核蛋白表达的影响[J].中国药理学通报,2013,29(8):1076—1079.
[2]ROSSI L,MAZZITELLI S,ARCIELLO M,et al.Benefits from dietary polyphenols for brain aging and Alzheimer’s disease[J].Neurochem Res,2008,33(12):2390—2400.
[3]PEREIRA AG,PORTUGUEZ MW,DACOSTA DI,et al.Route learning performance:is it a hippocampus function?[J].Cognitive and Behavionral Neurology,2011,24(1):4—10.
[4]何丽娅,李立中,吴基良.蝙蝠葛碱的抗氧化实验研究[J].中草药,1997,28(8):479—481.
[5]李艳红,黄向江,卢浩浩.蝙蝠葛碱对大鼠局灶性脑缺血及线粒体氧化损伤的保护作用[J].华中科技大学学报(医学版),2005,34(3):270—273.
[6]李艳红,龚培力.蝙蝠葛碱对实验小鼠脑缺血的保护作用[J].中国药理学通报,2004,20(5):564—567.
[7]何胜,玉莹,陈菊芳,等.D-半乳糖加亚硝酸钠建立痴呆症小鼠模型和中药治疗的效果[J].中国老年学杂志,2014,34(2):422—424.
[8]周妍妍,刘艳丽,董春雪,等.五味子醇甲对APP/PS1双转基因痴呆模型小鼠脑组织突触素、α-突触核蛋白表达的影响[J].中国药理学通报,2013,29(8):1076—1079.