槐杞黄颗粒辅助治疗小儿过敏性紫癜30例临床观察
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摘要
目的观察槐杞黄颗粒辅助治疗小儿过敏性紫癜(HSP)的临床疗效。方法将60例HSP患儿随机分为治疗组和对照组,各30例。对照组口服维生素C片、芦丁片,治疗组在对照组治疗方法的基础上口服槐杞黄颗粒,连续治疗12周后统计疗效。结果对照组总有效率为73.33%,治疗组为93.33%,2组比较,差异有统计学意义(P<0.05)。治疗组紫癜与腹痛消失时间均短于对照组,差异有统计学意义(P<0.01);但2组关节痛消失时间比较,差异无统计学意义(P> 0. 05)。对照组复发8例(36.36%),治疗组复发2例(7.14%),2组比较,差异有统计学意义(P<0.05)。2组治疗前尿微量白蛋白(m Abl)、β2微球蛋白(β2-MG)水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后,2组上述指标均明显下降(P<0.05),且治疗组下降更显著(P<0.05)。结论槐杞黄颗粒辅助治疗小儿HSP疗效显著,复发率低。
Objective To observe the clinical efficacy on Huaiqihang Keli( 槐杞黄颗粒) as an adjunctive treatment for infantile Henoch-Schonlein purpura( HSP).Methods Sixty cases with HSP were randomly divided into treatment group and control group,with 30 cases in each.The control group was given oral vitamin C tablets and rutin tablets,while the treatment group was added with oral Huaiqihang Keli based on the treatment of the control group.We made statistics on clinical efficacy after 12 weeks consecutive treatment.Results The total effective rate of the control group was 73. 33%,that of the treatment group was 93. 33%,there was statistically significant difference between the two groups( P<0.05).The disappearance time of purpura and abdominalgia in the treatment group was both shorter than that in the control group,there was statistically significant difference between the two groups( P<0.01).But there was no significant difference in the disappearance time of arthrodynia between the two groups( P> 0.05). Eight cases( 36.36%) relapsed in the control group,while 2 cases( 7. 14%) relapsed in the treatment group,there was significant difference between the two groups( P < 0. 05). There were no significant differences in the levels of m Abl and β_2-MG between the two groups before treatment( P>0.05),and they had comparability.After treatment,the above-mentioned indicators of the two groups both decreased significantly( P<0.05),moreover,those of the treatment group decreased more significantly( P<0.05).Conclusion Huaiqihang Keli as an adjunctive treatment for HSP has significant clinical efficacy with low relapse rate.
Objective To observe the clinical efficacy on Huaiqihang Keli( 槐杞黄颗粒) as an adjunctive treatment for infantile Henoch-Schonlein purpura( HSP).Methods Sixty cases with HSP were randomly divided into treatment group and control group,with 30 cases in each.The control group was given oral vitamin C tablets and rutin tablets,while the treatment group was added with oral Huaiqihang Keli based on the treatment of the control group.We made statistics on clinical efficacy after 12 weeks consecutive treatment.Results The total effective rate of the control group was 73. 33%,that of the treatment group was 93. 33%,there was statistically significant difference between the two groups( P<0.05).The disappearance time of purpura and abdominalgia in the treatment group was both shorter than that in the control group,there was statistically significant difference between the two groups( P<0.01).But there was no significant difference in the disappearance time of arthrodynia between the two groups( P> 0.05). Eight cases( 36.36%) relapsed in the control group,while 2 cases( 7. 14%) relapsed in the treatment group,there was significant difference between the two groups( P < 0. 05). There were no significant differences in the levels of m Abl and β_2-MG between the two groups before treatment( P>0.05),and they had comparability.After treatment,the above-mentioned indicators of the two groups both decreased significantly( P<0.05),moreover,those of the treatment group decreased more significantly( P<0.05).Conclusion Huaiqihang Keli as an adjunctive treatment for HSP has significant clinical efficacy with low relapse rate.
引文
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[9]王素丽.小儿过敏性紫癜的中医审因论治[J].中医儿科杂志,2013,9(5):16-18.
[10]芦伟.槐杞黄颗粒对过敏性紫癜性肾炎患儿血清细胞因子的影响[J].中国药业,2015,24(18):47-49.
[11]曾丽娜,张建江,史佩佩,等.槐杞黄对儿童过敏性紫癜Th17/Treg失衡的干预作用[J].中华临床医师杂志(电子版),2016,10(7):934-937.
[12]何泽云,钱永苹,黄剑涛.槐杞黄颗粒剂对慢性肾炎肝肾阴虚证中医证候影响的临床观察[J].世界中西医结合杂志,2015,10(10):1412-1414.
[2]张奇文,朱锦善.实用中医儿科学[M].北京:中国中医药出版社,2016:1013.
[3]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:18-19.
[4]刘晓艳,何小解,易著文.肾小管功能检测对评价原发性肾小球疾病进展的意义[J].中国医师进修杂志,2000,2(8):465.
[5]沈茜,徐虹,宋善路,等.肾小管间质损害对儿童过敏性紫癜肾炎预后影响的探讨[J].中国实用儿科杂志,2003,6(18):356-358.
[6]胡明昌,姜新猷,黄文彦,等.小儿紫癜性肾炎中肾小管间质改变[J].临床儿科杂志,1995,13(1):38-40.
[7]曾萍,曾华松.过敏性紫癜的诊断与治疗[J].实用儿科临床杂志,2010,25(9):625-628.
[8]宋杉,桂金贵.中医药防治儿童过敏性紫癜性肾炎研究进展[J].中医儿科杂志,2013,9(4):59-62.
[9]王素丽.小儿过敏性紫癜的中医审因论治[J].中医儿科杂志,2013,9(5):16-18.
[10]芦伟.槐杞黄颗粒对过敏性紫癜性肾炎患儿血清细胞因子的影响[J].中国药业,2015,24(18):47-49.
[11]曾丽娜,张建江,史佩佩,等.槐杞黄对儿童过敏性紫癜Th17/Treg失衡的干预作用[J].中华临床医师杂志(电子版),2016,10(7):934-937.
[12]何泽云,钱永苹,黄剑涛.槐杞黄颗粒剂对慢性肾炎肝肾阴虚证中医证候影响的临床观察[J].世界中西医结合杂志,2015,10(10):1412-1414.