冠心病相关中医证候DNA甲基化研究进展
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摘要
<正>冠心病是由冠状动脉粥样硬化、冠状动脉痉挛、炎性狭窄等引起的冠状动脉供血不足,心肌急剧缺血缺氧,出现以发作性胸骨后或心前区疼痛为主要表现的临床综合症。冠心病是全球常见病、多发病,严重危害人类健康和生活质量[1]。冠心病属中医学"胸痹"、"心痛"范畴,病位在心,涉及肝、脾、肾等脏。《灵枢·五邪》指出:"邪在心,其病心痛";《素问·脏气法时论》亦说"心病者,胸中痛,胁支满,胁下痛,膺背肩胛间痛,两臂内痛"。DNA甲基化是DNA化学修饰的一
引文
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[25] 唐梅森.基于DNA单核苷酸多态性和甲基化修饰探讨早发冠心病血瘀证的相关易感基因的研究[D].长沙:湖南中医药大学,2015.
[26] 陈光,周浩强,刘咏梅,等.冠心病不稳定性心绞痛血瘀证患者IL-6基因甲基化研究及方法探讨[J].中国实验方剂学杂志,2017,23(19):1-4.
[27] 李楠,宫丽鸿,程修平.复方中药对急性冠脉综合征患者雌激素受体基因与基质金属蛋白酶-9基因甲基化水平的影响[J].中国中医急症,2015,24(10):1746-1749.
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[29] 黄海波.养心通脉方对早发冠心病血瘀证家系CHL1、ZEB2基因甲基化作用影响的研究[D].湖南:湖南中医药大学,2015.
[30] 李颖.中西医结合治疗对ACS(痰浊血瘀型)患者血浆TM基因启动子甲基化的影响[D].沈阳:辽宁中医药大学,2015.
[31] 迟映雪.中西医结合治疗对痰浊血瘀型ACS患者MMP-9基因启动子甲基化水平的影响[D].沈阳:辽宁中医药大学,2015.
[32] Nakatochi M,Ichihara S,Yamamoto K,et al.Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease[J].Clin Epigenetics,2017,9:54.
[33] 王萍,王丽萍,黄献平,等.冠心病血瘀证差异表达基因及其启动子甲基化状态的初步研究[J].中医杂志,2013,54(11):949-952.
[2] Suzuki MM,Bird A.DNA methylation landscapes:provocative insights from epigenomic[J].Nat Rev Genet,2008,9(6):465-476.
[3] 张志强,李君义.同型半胱氨酸与冠心病的相关性研究进展[J].国际检验医学杂志,2013,34(4):452-456.
[4] Li JJ,Li Q,Du HP,et al.Homocysteine triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA hypermethylation of CSE promoter[J].Int J Mol Sci,2015,16(6):12560-12577.
[5] Sharma P,Kumar J,Garg G,et al.Detection of altered global DNA methylation in coronary artery disease patients[J].DNA Cell Biol,2008,27(7):357-365.
[6] Sharma P,Garg G,Kumar A,et al.Genome wide DNA methylation profiling for epigenetic alteration in coronary artery disease patients[J].Gene,2014,541(1):31-40.
[7] Castardo-de-Paula JC,de Campos BH,Amorim EDT,et al.Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats:The role of estrogen[J].Exp Gerontol,2017,97:38-48.
[8] Huang G,Wang D,Zeb I,et al.Intrathoracic fat,cardiometabolic risk factors,and subclinical cardiovascular disease in healthy,recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS)[J].Atherosclerosis,2012,221(1):198-205.
[9] Kim J,Kim JY,Song KS,et al.Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence[J].Biochim Biophys Acta,2007,1772(1):72-80.
[10] Post WS,Goldschmidt-Clermont PJ,Wilhide CC,et al.Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system[J].Cardiovasc Res,1999,43(4):985-991.
[11] Huang YS,Zhi YF,Wang SR.Hypermethylation of estrogen receptor-alpha gene in atheromatosis patients and its correlation with homocysteine[J].Pathophysiology,2009,16(4):259-65.
[12] 靳松,沈干,胡世莲,等.雌激素受体α启动子区甲基化与冠状动脉粥样硬化的关系[J].中国老年学杂志,2011,31(7):1102-1104.
[13] Kunz J.Matrix metalloproteinases and atherogenesis in dependence of age[J].Gerontology,2007,53(2):63-73.
[14] 刘振江,刘启明,周胜华.冠心病患者MMP-9基因DNA去甲基化及其异常表达的研究[J].中国医药指南,2011,9(25):177-179.
[15] Hasib L,Lundberg AK,Zachrisson H,et al.Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease[J].J Intern Med,2016,279(1):63-77.
[16] Hori S.The Foxp3 interactome:a network perspective of T(reg) cells[J].Nat Immunol,2012,13(10):943-945.
[17] Zheng Y,Josefowicz S,Chaudhry A,et al.Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate[J].Nature,2010,463(7282):808-812.
[18] 贾镭,祝领,王晓建,等.应用焦磷酸测序法检测FOXP3基因在冠心病患者中的去甲基化水平[J].中国分子心脏病学杂志,2016,16(5):1842-1845.
[19] Guay SP,Brisson D,Munger J,et al.ABCA1 gene promoter DNA methylation is associated with HDL particle profile and coronary artery disease in familial hypercholesterolemia[J].Epigenetics,2012,7(5):464-472.
[20] Guay SP,Légaré C,Houde AA,et al.Acetylsalicylic acid,aging and coronary artery disease are associated with ABCA1 DNA methylation in men[J].Clin Epigenetics,2014,6(1):14.
[21] Peng P,Wang L,Yang X,et al.A preliminary study of the relationship between promoter methylation of the ABCG1,GALNT2 and HMGCR genes and coronary heart disease[J].PLoS One,2014,9(8):e102265.
[22] 张笑天,郑晓瑛.氧化自由基清除剂超氧化物歧化酶与疾病[J].中国公共卫生,2014,30(10):1349-1352.
[23] 袁颐捷,朱智勇,韩毅.BNIP3蛋白在缺血性心血管疾病中作用的研究[J].心血管康复医学杂志,2011,20(2):182-185.
[24] Lakshmi SV,Naushad SM,Reddy CA,et al.Oxidative stress in coronary artery disease:epigenetic perspective[J].Mol Cell Biochem,2013,374(1-2):203-211.
[25] 唐梅森.基于DNA单核苷酸多态性和甲基化修饰探讨早发冠心病血瘀证的相关易感基因的研究[D].长沙:湖南中医药大学,2015.
[26] 陈光,周浩强,刘咏梅,等.冠心病不稳定性心绞痛血瘀证患者IL-6基因甲基化研究及方法探讨[J].中国实验方剂学杂志,2017,23(19):1-4.
[27] 李楠,宫丽鸿,程修平.复方中药对急性冠脉综合征患者雌激素受体基因与基质金属蛋白酶-9基因甲基化水平的影响[J].中国中医急症,2015,24(10):1746-1749.
[28] 向忠军.基于甲基化修饰探讨加减养心通脉方对冠心病血瘀证及亚型CTNNB1、DES基因表达的影响研究[D].长沙:湖南中医药大学,2015.
[29] 黄海波.养心通脉方对早发冠心病血瘀证家系CHL1、ZEB2基因甲基化作用影响的研究[D].湖南:湖南中医药大学,2015.
[30] 李颖.中西医结合治疗对ACS(痰浊血瘀型)患者血浆TM基因启动子甲基化的影响[D].沈阳:辽宁中医药大学,2015.
[31] 迟映雪.中西医结合治疗对痰浊血瘀型ACS患者MMP-9基因启动子甲基化水平的影响[D].沈阳:辽宁中医药大学,2015.
[32] Nakatochi M,Ichihara S,Yamamoto K,et al.Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease[J].Clin Epigenetics,2017,9:54.
[33] 王萍,王丽萍,黄献平,等.冠心病血瘀证差异表达基因及其启动子甲基化状态的初步研究[J].中医杂志,2013,54(11):949-952.