新疆地区汉族男性痛风患者糖、脂代谢紊乱的相关性研究
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摘要
目的探讨新疆地区汉族男性血尿酸(SUA)水平与糖、脂代谢指标的相关性。方法收集2016-2017年新疆医科大学第一附属医院风湿科痛风患者203例为痛风组,同期体检中心健康者305例为对照组,6h内采用日立7600全自动分析仪检测SUA、三酰甘油(TG)和总胆固醇(TC)等糖、脂代谢指标,并利用SPSS22.0软件进行数据处理和统计分析。结果痛风组和对照组SUA水平分别为(501.66±8.29)、(355.49±6.81)μmol/L,痛风组高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和载脂蛋白B(apoB)分别为(1.02±0.02)、(2.63±0.55)、(0.96±0.21)mmol/L,对照组HDL、LDL和apoB分别为(1.33±0.04)、(3.06±0.12)、(0.73±0.24)mmol/L,两组比较差异有统计学意义(P<0.05),体质量指数(BMI)和腰臀比在两组人群中差异有统计学意义(P<0.05)。SUA和脂蛋白(a)与痛风的发生呈正相关关系(r=0.553、0.153,P<0.05),而HDL、LDL和apoB与痛风呈负相关(r=-0.495、-0.170、-0.324,P<0.05)。结论汉族痛风患者更易引起脂代谢紊乱,而SUA水平的升高可能是糖、脂代谢紊乱的促进因素或SUA水平与糖、脂代谢紊乱相互影响。
Objective To explore the correlation of serum uric acid levels with sugar and lipid metabolism in the Han population in Xinjiang.Methods 203 cases of rheumatology gout patients in the First Affiliated Hospital of Xinjiang Medical University from 2016 to 2017 were collected,and 305 healthy controls from the physical examination center in the same period were collected.The sugar and lipid metabolism indexes such as serum SUA,TG and TC were detected by Hitachi 7600 automatic analyzer within 6 hours,and SPSS22.0 software was used for data processing and statistical analysis.Results The SUA levels in the gout group and the control group were(501.66±8.29)and(355.49±6.81)μmol/L,respectively.The HDL,LDL and apoB in the gout group were(1.02±0.02),(2.63±0.55),and(0.96±0.21)μmol/L,respectively.The HDL,LDL and apoB in the control group were(1.33±0.04),(3.06±0.12),(0.73±0.24)mmol/L,respectively.There was significant difference between the two groups(P<0.05).BMI and waist-ratio was also statistically different between the two groups(P<0.05).There was a positive correlation between SUA and lipoprotein(a)with gout(r=0.553,0.153,P<0.05),while HDL,LDL and apoB were negatively correlated(r=-0.495,-0.170,-0.324,P<0.05).Conclusion Patients with gout are more likely to cause disorders of lipid metabolism.Increased blood SUA may be a contributing factor to the disorder of glucose and lipid metabolism or the interaction between uric acid levels and disorders of glucose and lipid metabolism.
Objective To explore the correlation of serum uric acid levels with sugar and lipid metabolism in the Han population in Xinjiang.Methods 203 cases of rheumatology gout patients in the First Affiliated Hospital of Xinjiang Medical University from 2016 to 2017 were collected,and 305 healthy controls from the physical examination center in the same period were collected.The sugar and lipid metabolism indexes such as serum SUA,TG and TC were detected by Hitachi 7600 automatic analyzer within 6 hours,and SPSS22.0 software was used for data processing and statistical analysis.Results The SUA levels in the gout group and the control group were(501.66±8.29)and(355.49±6.81)μmol/L,respectively.The HDL,LDL and apoB in the gout group were(1.02±0.02),(2.63±0.55),and(0.96±0.21)μmol/L,respectively.The HDL,LDL and apoB in the control group were(1.33±0.04),(3.06±0.12),(0.73±0.24)mmol/L,respectively.There was significant difference between the two groups(P<0.05).BMI and waist-ratio was also statistically different between the two groups(P<0.05).There was a positive correlation between SUA and lipoprotein(a)with gout(r=0.553,0.153,P<0.05),while HDL,LDL and apoB were negatively correlated(r=-0.495,-0.170,-0.324,P<0.05).Conclusion Patients with gout are more likely to cause disorders of lipid metabolism.Increased blood SUA may be a contributing factor to the disorder of glucose and lipid metabolism or the interaction between uric acid levels and disorders of glucose and lipid metabolism.
引文
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[9]黄晖明,王人卫,李森,等.体重指数与体脂率指标评价肥胖:基于诊断试验的比较研究[J].中国运动医学杂志,2017,36(3):218-225.
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[11]孙玉萍,陆影,高新,等.汉族、维吾尔族和哈萨克族人群内脏脂肪素水平与尿酸、脂代谢指标的相关性[J].临床检验杂志,2015,33(4):258-261.
[12]青玉凤,刘晶,周京国,等.原发性痛风患者326例血尿酸、胱抑素C和脂代谢特点分析及其临床意义[J/CD].中华临床医师杂志:电子版,2013,7(7):29-32.
[13]李敏,周京国,杨其彬,等.痛风患者血脂水平分析[J].中国临床医学,2011,18(1):117-119.
[14]李慧,刘振,李长贵,等.痛风伴发糖尿病的危险因素探讨[J].中国糖尿病杂志,2015(9):547-552.
[15]AUNE D,NORAT T,VATTEN L J.Body mass index and the risk of gout:a systematic review and dose-response meta-analysis of prospective studies[J].Eur J Nutr,2014,53(8):1591-1598.
[16]余家会,张蓓,古丽尼扎,哈力阿克帕尔,等.HUA与脂代谢紊乱的关系及其民族异质性分析[J].国际检验医学杂志,2015,36(2):145-147.
[17]蒲梦君,周京国,青玉凤,等.痛风合并糖尿病患者的临床指标分析[J/CD].中华临床医师杂志(电子版),2013,7(13):6118-6120.
[2]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):410-413.
[3]中华医学会风湿病学分会.2016中国痛风诊疗指南[J].中华内科杂志,2016,55(11):892-899.
[4]KATSIKI N,PAPANAS N,FONSECA V A,et al.Uric acid and diabetes:Is there a link?[J].Curr Pharm Des,2013,19(27):35-38.
[5]NEOGI T,JANSEN T L,DALBETH N,et al.2015Gout classification criteria:an American College of Rheumatology/European League Against Rheumatism collaborative initiative[J].Ann Rheum Dis,2015,74(10):1789-1798.
[6]王靖宇,常宝成.HUA/痛风流行病学特点及危险因素[J].国际内分泌代谢杂志,2016,36(2):81-87.
[7]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华内分泌代谢杂志,2014,30(10):447-498.
[8]诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,16(10):15-35.
[9]黄晖明,王人卫,李森,等.体重指数与体脂率指标评价肥胖:基于诊断试验的比较研究[J].中国运动医学杂志,2017,36(3):218-225.
[10]YIN J,LIU C X,YU H P,et al.The prevalence of hyperuricemia in China:a meta-analysis[J].Bmc Public Health,2011,11(1):832-838.
[11]孙玉萍,陆影,高新,等.汉族、维吾尔族和哈萨克族人群内脏脂肪素水平与尿酸、脂代谢指标的相关性[J].临床检验杂志,2015,33(4):258-261.
[12]青玉凤,刘晶,周京国,等.原发性痛风患者326例血尿酸、胱抑素C和脂代谢特点分析及其临床意义[J/CD].中华临床医师杂志:电子版,2013,7(7):29-32.
[13]李敏,周京国,杨其彬,等.痛风患者血脂水平分析[J].中国临床医学,2011,18(1):117-119.
[14]李慧,刘振,李长贵,等.痛风伴发糖尿病的危险因素探讨[J].中国糖尿病杂志,2015(9):547-552.
[15]AUNE D,NORAT T,VATTEN L J.Body mass index and the risk of gout:a systematic review and dose-response meta-analysis of prospective studies[J].Eur J Nutr,2014,53(8):1591-1598.
[16]余家会,张蓓,古丽尼扎,哈力阿克帕尔,等.HUA与脂代谢紊乱的关系及其民族异质性分析[J].国际检验医学杂志,2015,36(2):145-147.
[17]蒲梦君,周京国,青玉凤,等.痛风合并糖尿病患者的临床指标分析[J/CD].中华临床医师杂志(电子版),2013,7(13):6118-6120.