微RNA在心血管疾病中的研究进展
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摘要
随着社会经济的发展,人口老龄化进程的加快,居民生活方式的改变等因素导致心血管疾病的患病率持续升高。微RNA(miRNA)在心血管疾病的发展进程中起着至关重要的作用。许多心肌miRNA的表达在心血管疾病的进展中发生了改变,这些改变加深了人们对心血管疾病的发生机制、诊断标志物和治疗靶点的认识。心血管功能障碍中发生的miRNA的诱导或抑制以细胞特有的方式触发下游的心脏事件。此外,内源性miRNA的干扰可以通过外源性过表达或中和策略进行修饰,以缓和心肌受损功能。
With the development of social economy,the acceleration of population aging and the change of lifestyle,the risk factors of these cardiovascular diseases continue to increase,leading to the increase of cardiovascular diseases prevalence.microRNA( miRNA) plays a vital role in the development of cardiovascular diseases. In the progression of cardiovascular diseases,many miRNA expression changes in the myocardium have deepened people' s understanding of the pathogenesis,diagnostic markers and therapeutic targets of cardiovascular diseases. The induction or repression of miRNAs occurring in cardiovascular dysfunction triggers downstream cardiac events in a cell specific manner. Besides,the endogenous miRNAs' disturbance can be modified to rescue cardiac function through exogenous overexpressing or neutralizing strategy.
With the development of social economy,the acceleration of population aging and the change of lifestyle,the risk factors of these cardiovascular diseases continue to increase,leading to the increase of cardiovascular diseases prevalence.microRNA( miRNA) plays a vital role in the development of cardiovascular diseases. In the progression of cardiovascular diseases,many miRNA expression changes in the myocardium have deepened people' s understanding of the pathogenesis,diagnostic markers and therapeutic targets of cardiovascular diseases. The induction or repression of miRNAs occurring in cardiovascular dysfunction triggers downstream cardiac events in a cell specific manner. Besides,the endogenous miRNAs' disturbance can be modified to rescue cardiac function through exogenous overexpressing or neutralizing strategy.
引文
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[9]Yan M,Chen C,Gong W,et al.miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8[J].Cardiovasc Res,2015,105(3):340-352.
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[15]Ohyagi-Hara C,Sawada K,Kamiura S,et al.miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrinα5 expression[J].Am J Pathol,2013,182(5):1876-1889.
[16]Hinkel R,Penzkofer D,Zühlke S,et al.Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model[J].Circulation,2013,128(10):1066-1075.
[17]Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2):261-271.
[18]Chistiakov DA,Orekhov AN,Bobryshev YV.The role of miR-126in embryonic,adult vascular homeostasis,and vascular repair and its alterations in atherosclerotic disease[J].J Mol Cell Cardiol,2016,97:47-55.
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[23]CarèA,Catalucci D,Felicetti F,et al.microRNA-133 controls cardiac hypertrophy[J].Nat Med,2007,13(5):613-618.
[24]Li Q,Song XW,Zou J,et al.Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy[J].J Cell Sci,2010,123(Pt 14):2444-2452.
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[28]Diniz GP,Lino CA,Guedes EC,et al.Cardiac microRNA-133 is down-regulated in thyroid hormone-mediated cardiac hypertrophy partially via Type 1 AngiotensinⅡreceptor[J].Basic Res Cardiol,2015,110(5):49.
[29]Feng B,Chen S,George B,et al.miR133a regulates cardiomyocyte hypertrophy in diabetes[J].Diabetes Metab Res Rev,2010,26(1):40-49.
[30]Chen S,Puthanveetil P,Feng B,et al.Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes[J].J Cell Mol Med,2014,18(3):415-421.
[31]方际,林丽.缺血心肌microRNAs的表达变化以及microRNA-378的保护效应研究[D].上海:第二军医大学,2010.
[32]Ganesan J,Ramanujam D,Sassi Y,et al.MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors[J].Circulation,2013,127(21):2097-2106.
[33]Nagalingam RS,Sundaresan NR,Gupta MP,et al.A cardiacenriched microRNA,miR-378,blocks cardiac hypertrophy by targeting Ras signaling[J]J Biol Chem,2013,288(16):11216-11232.
[34]Chen Z,Ding HS,Guo X,et al.MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling[J].Oncotarget,2018,9(31):22047-22057.
[35]Yu B,Li W,AI F,et al.MicroRNA-33a deficiency inhibits proliferation and fibrosis through inactivation of TGF-β/Smad pathway in human cardiac fibroblasts[J].Pharmazie,2017,8,72(8):456-460.
[36]Baba O,Horie T,Nakao T,et al.MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6ChighMonocytes through Dual Pathways[J].Mol Cell Biol,2018,38(14).pii:e00604-00617.
[37]Price NL,Singh AK,Rotllan N,et al.Genetic Ablation of miR-33Increases Food Intake,Enhances Adipose Tissue Expansion,and Promotes Obesity and Insulin Resistance[J].Cell Rep,2018,22(8):2133-2145.
[38]曾宪友,谭毅.microRNA及其与心律失常关系的研究进展[J].中国临床新医学,2015,8(8):796-799.
[39]Hata A.Functions of microRNAs in cardiovascular biology and disease[J].Annu Rev Physiol,2013,75:69-93.
[2]国家心血管病中心.中国心血管病报告(2017)[M].北京:中国大百科全书出版社,2017:1-198.
[3]马玉梅,韦淑萍,黄佳雯,等.微小RNA在心肌肥厚中的研究进展[J].中国急救复苏与灾害医学杂志,2015,10(12):1198-1201.
[4]Zhao Y,Samal E,Srivastava D,et al.Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis[J].Nature,2005,436(7048):214-220.
[5]van Rooij E,Sutherland LB,Liu N,et al.A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure[J].Proc Natl Acad Sci U S A,2006,103(48):18255-18260.
[6]Malizia AP,Wang DZ.MicroRNA in cardiomyocyte Development[J].Wiley Interdiscip Rev Syst Biol Med,2011,3(2):183-190.
[7]Di Stefano V,Zaccagnini G,Capogrossi MC,et al.MicroRNAs as peripheral blood biomakers of cardiovascular disease[J].Vascular Pharmacology,2011,55(4):111-118.
[8]Oka T,Akazawa H,Naito AT,et al.Angiogenesis and cardiac hypertrophy:Maintenance of cardiac function and causative roles in heart failure[J].Circ Res,2014,114(3):565-571.
[9]Yan M,Chen C,Gong W,et al.miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8[J].Cardiovasc Res,2015,105(3):340-352.
[10]Wronska A,Kurkowska-Jastrzebska I,Santulli G.Application of microRNAs in diagnosis and treatment of cardiovascular disease[J].Acta Physiol(Oxf),2015,213(1):60-83.
[11]张明娟,吕卓人.心肌肥厚发生机制的研究进展[J].中国实用内科杂志,2002,22(7):437-438.
[12]Bao Q,Chen L,Li J,et al.Role of microRNA-124 in cardiomyocyte hypertrophy induced by angiotensinⅡ[J].Cell Mol Biol(Noisy-le-grand),2017,63(4):23-27.
[13]Zhao Y,Yan M,Chen C,et al.MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart[J].Oncotarget,2018,9(18):14382-14396.
[14]Doebele C,Bonauer A,Fischer A,et al.Members of the microR-NA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells[J].Blood,2010,115(23):4944-4950.
[15]Ohyagi-Hara C,Sawada K,Kamiura S,et al.miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrinα5 expression[J].Am J Pathol,2013,182(5):1876-1889.
[16]Hinkel R,Penzkofer D,Zühlke S,et al.Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model[J].Circulation,2013,128(10):1066-1075.
[17]Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2):261-271.
[18]Chistiakov DA,Orekhov AN,Bobryshev YV.The role of miR-126in embryonic,adult vascular homeostasis,and vascular repair and its alterations in atherosclerotic disease[J].J Mol Cell Cardiol,2016,97:47-55.
[19]Jakob P,Doerries C,Briand S,et al.Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronicheart failure:Role for impaired in vivo neovascularization and cardiac repair capacity[J].Circulation,2012,126(25):2962-2975.
[20]Huang X,Li Z,Bai B,et al.High expression of microRNA-208 is associated with cardiac hypertrophy via the negative regulation of the sex-determining region Y-box 6 protein[J].Exp Ther Med,2015,10(3):921-926.
[21]Callis TE,Pandya K,Seok HY,et al.MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice[J].J Clin Invest,2009,119(9):2772-2786.
[22]Montgomery RL,Hullinger TG,Semus HM,et al.Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure[J].Circulation,2011,124(14):1537-1547.
[23]CarèA,Catalucci D,Felicetti F,et al.microRNA-133 controls cardiac hypertrophy[J].Nat Med,2007,13(5):613-618.
[24]Li Q,Song XW,Zou J,et al.Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy[J].J Cell Sci,2010,123(Pt 14):2444-2452.
[25]Villar AV,García R,Merino D,et al.Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients[J].Int J Cardiol,2013,167(6):2875-2881.
[26]Danowski N,Manthey I,Jakob HG,et al.Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery[J].Cardiology,2013,125(2):125-130.
[27]Dong DL,Chen C,Huo R,et al.Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy:Anovel mechanism for progressive cardiac hypertrophy[J].Hypertension,2010,55(4):946-952.
[28]Diniz GP,Lino CA,Guedes EC,et al.Cardiac microRNA-133 is down-regulated in thyroid hormone-mediated cardiac hypertrophy partially via Type 1 AngiotensinⅡreceptor[J].Basic Res Cardiol,2015,110(5):49.
[29]Feng B,Chen S,George B,et al.miR133a regulates cardiomyocyte hypertrophy in diabetes[J].Diabetes Metab Res Rev,2010,26(1):40-49.
[30]Chen S,Puthanveetil P,Feng B,et al.Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes[J].J Cell Mol Med,2014,18(3):415-421.
[31]方际,林丽.缺血心肌microRNAs的表达变化以及microRNA-378的保护效应研究[D].上海:第二军医大学,2010.
[32]Ganesan J,Ramanujam D,Sassi Y,et al.MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors[J].Circulation,2013,127(21):2097-2106.
[33]Nagalingam RS,Sundaresan NR,Gupta MP,et al.A cardiacenriched microRNA,miR-378,blocks cardiac hypertrophy by targeting Ras signaling[J]J Biol Chem,2013,288(16):11216-11232.
[34]Chen Z,Ding HS,Guo X,et al.MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling[J].Oncotarget,2018,9(31):22047-22057.
[35]Yu B,Li W,AI F,et al.MicroRNA-33a deficiency inhibits proliferation and fibrosis through inactivation of TGF-β/Smad pathway in human cardiac fibroblasts[J].Pharmazie,2017,8,72(8):456-460.
[36]Baba O,Horie T,Nakao T,et al.MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6ChighMonocytes through Dual Pathways[J].Mol Cell Biol,2018,38(14).pii:e00604-00617.
[37]Price NL,Singh AK,Rotllan N,et al.Genetic Ablation of miR-33Increases Food Intake,Enhances Adipose Tissue Expansion,and Promotes Obesity and Insulin Resistance[J].Cell Rep,2018,22(8):2133-2145.
[38]曾宪友,谭毅.microRNA及其与心律失常关系的研究进展[J].中国临床新医学,2015,8(8):796-799.
[39]Hata A.Functions of microRNAs in cardiovascular biology and disease[J].Annu Rev Physiol,2013,75:69-93.