盐酸莫西沙星的单晶制备及其结构表征
|
摘要
目的培养盐酸莫西沙星的单晶,并对其进行结构表征。方法通过溶剂挥发法制备盐酸莫西沙星单晶,并采用热重分析仪(TGA)–差示扫描量热仪(DSC)和粉末X射线衍射仪(PXRD)对其结晶形态进行了表征。结果制备得到盐酸莫西沙星无色透明针状结晶。TGA-DSC结果显示盐酸莫西沙星单晶熔点为255℃。单晶X射线衍射结果表明该晶胞属于单斜晶系,P2_1空间群,分子式为C_(43)H_(56)Cl_2F_2N_6O_(10),相对分子质量为925.84。结论采用X射线单晶衍射确证了盐酸莫西沙星单晶的结构,为盐酸莫西沙星的进一步开发提供了研究基础。
Objective To cultivate single crystal of moxifloxacin hydrochloride, and to characterize the structure of moxifloxacin hydrochloride. Methods Evaporation methods was applied to grow single crystal of moxifloxacin hydrochloride. The crystal structure of moxifloxacin hydrochloride was studied by X-ray diffraction, and the structure of moxifloxacin hydrochloride was characterized by thermogravimetric analysis(TGA)-differential scanning calorimetry(DSC) and powder X-ray diffraction(PXRD).Results Moxifloxacin hydrochloride colorless acicular crystal was obtained. Referring to the TGA-DSC results, the melting temperature of moxifloxacin hydrochloride was determined to be around 255 ℃. Single crystal X-ray diffractometer confirmed the monoclinic lattice with space group P2_1 in moxifloxacin hydrochloride. Moreover, the chemical formula and relative molecular mass were C_(43)H_(56)Cl_2F_2N_6O_(10) and 925.84, respectively. Conclusion The single crystal structure of moxifloxacin hydrochloride is characterized by single crystal X-ray diffractometer, which provides a basis for the further development of moxifloxacin hydrochloride.
Objective To cultivate single crystal of moxifloxacin hydrochloride, and to characterize the structure of moxifloxacin hydrochloride. Methods Evaporation methods was applied to grow single crystal of moxifloxacin hydrochloride. The crystal structure of moxifloxacin hydrochloride was studied by X-ray diffraction, and the structure of moxifloxacin hydrochloride was characterized by thermogravimetric analysis(TGA)-differential scanning calorimetry(DSC) and powder X-ray diffraction(PXRD).Results Moxifloxacin hydrochloride colorless acicular crystal was obtained. Referring to the TGA-DSC results, the melting temperature of moxifloxacin hydrochloride was determined to be around 255 ℃. Single crystal X-ray diffractometer confirmed the monoclinic lattice with space group P2_1 in moxifloxacin hydrochloride. Moreover, the chemical formula and relative molecular mass were C_(43)H_(56)Cl_2F_2N_6O_(10) and 925.84, respectively. Conclusion The single crystal structure of moxifloxacin hydrochloride is characterized by single crystal X-ray diffractometer, which provides a basis for the further development of moxifloxacin hydrochloride.
引文
[1]卢定强,王维胞,凌岫泉,等.新一代喹诺酮类盐酸莫西沙星的合成及应用研究进展[J].现代化工,2014,34(2):33-37.
[2]刘锋涛,张玮.莫西沙星与左氧氟沙星治疗社区获得性肺炎的效果分析[J].中国医药导刊,2013,15(3):509-510.
[3]孙国强.莫西沙星治疗非淋茵性尿道(宫颈)炎的疗效和安全性观察[J].海南医学,2007,18(10):128-147.
[4]陈峰恩,王华,杨世贤.莫西沙星治疗急性细菌性鼻窦炎的临床疗效观察[J].药物与临床,2012,19(19):89-90.
[5]Lipsky B A,Giordano P,Choudhri S,et al.Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam amoxicillin-clavulanate[J].Antimicrob Chemother,2007,60(2):370-376.
[6]谢寅省,高红云,刘实.卡巴他赛的单晶培养和结构确证[J].现代药物与临床,2016,31(12):1879-1882.
[7]李玉荃,王亚江,刘志友,等.布南色林的单晶培养和结构确证[J].现代药物与临床,2011,26(3):216-218.
[2]刘锋涛,张玮.莫西沙星与左氧氟沙星治疗社区获得性肺炎的效果分析[J].中国医药导刊,2013,15(3):509-510.
[3]孙国强.莫西沙星治疗非淋茵性尿道(宫颈)炎的疗效和安全性观察[J].海南医学,2007,18(10):128-147.
[4]陈峰恩,王华,杨世贤.莫西沙星治疗急性细菌性鼻窦炎的临床疗效观察[J].药物与临床,2012,19(19):89-90.
[5]Lipsky B A,Giordano P,Choudhri S,et al.Treating diabetic foot infections with sequential intravenous to oral moxifloxacin compared with piperacillin-tazobactam amoxicillin-clavulanate[J].Antimicrob Chemother,2007,60(2):370-376.
[6]谢寅省,高红云,刘实.卡巴他赛的单晶培养和结构确证[J].现代药物与临床,2016,31(12):1879-1882.
[7]李玉荃,王亚江,刘志友,等.布南色林的单晶培养和结构确证[J].现代药物与临床,2011,26(3):216-218.