社区人群促甲状腺素水平与血脂的相关性分析
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摘要
目的探讨社区人群不同TSH水平及血脂之间的相关性。方法选自2013年5月至6月在乌鲁木齐某社区甲状腺疾病流行病学调查资料,资料完整的1185例列入本研究(男/女:364/821,年龄:18～84岁,平均年龄:43.3±12.9岁),根据本实验室甲状腺功能检测的TSH正常参考范围将其分为四组:低于正常范围、正常范围、高于正常范围但小于10.0μIU/mL、TSH大于10μIU/mL;分析不同程度TSH水平对血脂的影响,并分析相关性。采用单因素方差分析、t检验、Pearson相关分析进行统计学分析。结果①按不同程度TSH水平分组后,其中TC、LDL-C、HDL-C水平均随着TSH水平增高呈上升趋势。②在控制年龄、性别后按不同程度TSH水平分组,在正常TSH范围内,TSH与TG(r=0.091,P=0.007)呈正相关。TSH大于10μIU/mL组,TSH与TC(r=0.417,P=0.025)和TG(r=0.668,P<0.001)呈正相关。结论TSH在正常范围内TSH与TG呈正相关,TSH大于10μIU/mL,TSH与TC及TG呈不同程度的正相关。
Objective Exploring the correlation between different TSH levels and blood lipids in community population.Methods The selected data from epidemiological survey of thyroid diseases in a community in Urumqi from May to June,2013 was used for the study.1185 cases with complete data were included in the study(male/female:364/821),aged 18-84 years(average Age:43.3±12.9 years).According to the normal reference range of thyroid function test in our laboratory,TSH was divided into four groups:TSH was lower than the normal range;TSH normal range;TSH was higher than the normal range but less than 10.0 μIU/mL,TSH was greater than 10μIU/m.The effects of different levels of TSH on blood lipids were analyzed and correlations were evaluated.Statistical analysis was performed by one-way analysis of variance,t-test,and Pearson correlation analysis.Results①After grouping according to different levels of TSH,the levels of TC,LDL-C and HDL-C increased with the increase of TSH level.②After controlling age and gender,cases were grouped according to different levels of TSH.In the normal TSH range,TSH was positively correlated with TG(r=0.091,P=0.007).For TSH greater than 10 μIU/mL group,TSH was positively correlated with TC(r=0.417,P=0.025)and TG(r=0.668,P<0.001).Conclusion TSH is positively correlated with TG in the normal range.When TSH is greater than 10 μIU/mL,it positively correlated with TC and TG with different degrees.
Objective Exploring the correlation between different TSH levels and blood lipids in community population.Methods The selected data from epidemiological survey of thyroid diseases in a community in Urumqi from May to June,2013 was used for the study.1185 cases with complete data were included in the study(male/female:364/821),aged 18-84 years(average Age:43.3±12.9 years).According to the normal reference range of thyroid function test in our laboratory,TSH was divided into four groups:TSH was lower than the normal range;TSH normal range;TSH was higher than the normal range but less than 10.0 μIU/mL,TSH was greater than 10μIU/m.The effects of different levels of TSH on blood lipids were analyzed and correlations were evaluated.Statistical analysis was performed by one-way analysis of variance,t-test,and Pearson correlation analysis.Results①After grouping according to different levels of TSH,the levels of TC,LDL-C and HDL-C increased with the increase of TSH level.②After controlling age and gender,cases were grouped according to different levels of TSH.In the normal TSH range,TSH was positively correlated with TG(r=0.091,P=0.007).For TSH greater than 10 μIU/mL group,TSH was positively correlated with TC(r=0.417,P=0.025)and TG(r=0.668,P<0.001).Conclusion TSH is positively correlated with TG in the normal range.When TSH is greater than 10 μIU/mL,it positively correlated with TC and TG with different degrees.
引文
[1]RIZOS C V,ELISAF M S,LIBEROPOULOS E N.Effects of thyroid dysfunction on lipid profile[J].Open Cardiovasc Med J,2011,5:76-84.
[2]PEARCE E N.Hypothyroidism and dyslipidemia:modern concepts and approaches[J].Curr Cardiol Rep,2004,6(6):451-456.
[3]ASLOLD B 0,VATTEN L J,NILSEN T L,et al.The association between TSH with in the refence range and serum lipid concentrations in a populationbased study.The HUNT Study[J].Eur J Endocrinol,2007,156(6):181-186.
[4]SASAKI S,KAWAI K.Thyroid hoemones and lipid metabolism[J].Nihon Rinsho,2006,64(12):2323-2329.
[5]MENG Z,LIU M,ZHANG Q,et al.Gender and age impact on the association between thyroid-stimulating hormone and serum lipids[J].Medicine(Baltimore),2015,94(49):e2186.
[6]DUNTAS L H,BRENTA G.A renewed focus on the association between thyroid hormones and lipid metabolism[J]. Front Endocrinol,2018,9:511.
[7]GUTCH M,RUNGTA S,KUMAR S,et al.Thyroid functions and serum lipid profile in metabolic syndrome[J].Biomed J,2017,40(3):147-153.
[8]TAGAMI T,KIMURA H,OHTANI S,et al.Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia[J].Endocr J,2011,58(6):449-457.
[9]GARBER J R,COBIN R H,GHARIB H,et al.Clinical practice guidelines for hypothyroidism in adults:cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association[J].Thyroid,2012,22(12):1200-1235.
[10]RUHLA S,WEICKERT M 0,ARAFAT A M,et al.A high normal TSH is associated with the metabolic syndrome[J].Clin Endocrinol(Oxf),2010,72(5):696-701.
[11]ZHANG Y,LU P,ZHANG L,et al.Association between lipids profile and thyroid parameters in euthyroid diabetic subjects:a crosssectional study[J].BMC Endocr Disord,2015,15:12.
[12]胡颖,时立新,张巧,等.正常甲状腺功能人群血清促甲状腺素与血脂异常的相关性[J].中华内分泌代谢杂志,2016,32(1):15-18.
[13]DUNTAS L H.Thyroid disease and lipids[J].Thyroid,2002,12(4):287-293.
[14]TIAN L,SONGY,XING M,et al.A novel role for thyroidstimulating hormone:Up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway[J].Hepatology,2010,52(4):1401-1409.
[15]SINHA R A,YOU S H,ZHOU J,et al.Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy[J].J Clin Invest,2012,122(7):2428-2438.
[2]PEARCE E N.Hypothyroidism and dyslipidemia:modern concepts and approaches[J].Curr Cardiol Rep,2004,6(6):451-456.
[3]ASLOLD B 0,VATTEN L J,NILSEN T L,et al.The association between TSH with in the refence range and serum lipid concentrations in a populationbased study.The HUNT Study[J].Eur J Endocrinol,2007,156(6):181-186.
[4]SASAKI S,KAWAI K.Thyroid hoemones and lipid metabolism[J].Nihon Rinsho,2006,64(12):2323-2329.
[5]MENG Z,LIU M,ZHANG Q,et al.Gender and age impact on the association between thyroid-stimulating hormone and serum lipids[J].Medicine(Baltimore),2015,94(49):e2186.
[6]DUNTAS L H,BRENTA G.A renewed focus on the association between thyroid hormones and lipid metabolism[J]. Front Endocrinol,2018,9:511.
[7]GUTCH M,RUNGTA S,KUMAR S,et al.Thyroid functions and serum lipid profile in metabolic syndrome[J].Biomed J,2017,40(3):147-153.
[8]TAGAMI T,KIMURA H,OHTANI S,et al.Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia[J].Endocr J,2011,58(6):449-457.
[9]GARBER J R,COBIN R H,GHARIB H,et al.Clinical practice guidelines for hypothyroidism in adults:cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association[J].Thyroid,2012,22(12):1200-1235.
[10]RUHLA S,WEICKERT M 0,ARAFAT A M,et al.A high normal TSH is associated with the metabolic syndrome[J].Clin Endocrinol(Oxf),2010,72(5):696-701.
[11]ZHANG Y,LU P,ZHANG L,et al.Association between lipids profile and thyroid parameters in euthyroid diabetic subjects:a crosssectional study[J].BMC Endocr Disord,2015,15:12.
[12]胡颖,时立新,张巧,等.正常甲状腺功能人群血清促甲状腺素与血脂异常的相关性[J].中华内分泌代谢杂志,2016,32(1):15-18.
[13]DUNTAS L H.Thyroid disease and lipids[J].Thyroid,2002,12(4):287-293.
[14]TIAN L,SONGY,XING M,et al.A novel role for thyroidstimulating hormone:Up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway[J].Hepatology,2010,52(4):1401-1409.
[15]SINHA R A,YOU S H,ZHOU J,et al.Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy[J].J Clin Invest,2012,122(7):2428-2438.