血清胆红素与糖尿病肾病的关系
摘要
目的研究不同严重程度的糖尿病肾病患者血清胆红素水平之间有无差异,探讨它与糖尿病肾病的关系。希望血清胆红素能作为一项有效的检测糖尿病肾病的指标,广泛应用于临床,预测糖尿病肾病的进展。方法收集T2DM患者共120例,2014年8月—2015年8月期间符合入选条件、排除条件的该科住院患者。根据糖尿病肾病诊断标准中尿白蛋白排泄率(UAER)将研究对象分为3组:小于20 ug/min为A组,即正常蛋白尿组;20~200μg/min为B组,微量蛋白尿组;大于200 ug/min为C组,大量蛋白尿组。分析3组间血清胆红素水平有无统计学意义、与尿蛋白之间是否存在关系。结果 3组患者之间血清胆红素水平差异有统计学意义(P<0.01),正常蛋白尿组的血清胆红素水平在3组中最高,差异有统计学意义(P<0.01)。且TBIL、DBIL及IBIL均与尿蛋白水平呈显著负相关(r=-0.62,P<0.01;r=-0.65,P<0.01;r=-0.53,P<0.01)。结论血清胆红素与糖尿病肾病的发生、发展有相关性,且这种关系为负相关,有保护意义。
引文
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[4]Maruhashi T,Soga J,Fujimura N,et al.Hyperbilirubinemia,augmentation ofendothelial function,and decrease in oxidative stress in Gilbert syndrome[J].Circulation,2012,126:598-603.
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[6]尤守唐,沈红艳.糖尿病肾病患者血清胆红素与血红蛋白的相关性及临床意义[J].中国医药指南,2015(13):16-17.
[7]杨丽萍,李平.糖尿病肾病合并贫血的相关发病机制研究进展[J].中国中西医结合肾病杂志,2009(10):172-174.
[8]Ritz E.Managing anemia and diabetes:a fut Lire challenge for nephrologist[J].Nephrol Dial Transplant,2005(Suppl6):21-25.
[2]Riphagen IJ,Deetman PE,Bakker SJL,et al.Bilirubin and progression of nephropathy in type 2 diabetes:a post-hoc analysis of RENAAL with independent replication in IDNT[J].Diabetes,2014,63:2845-2853.
[3]Adin CA,Croker BP,Agarwal A.Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated,perfused rat kidney[J].Am J Physiol Renal Physiol,2005,288:F778-F784.
[4]Maruhashi T,Soga J,Fujimura N,et al.Hyperbilirubinemia,augmentation ofendothelial function,and decrease in oxidative stress in Gilbert syndrome[J].Circulation,2012,126:598-603.
[5]Fujii M,Inoguchi T,Sasaki S,et al.Bilirubin and biliverdi nprotect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase[J].Kidney Int,2010,78:905-919.
[6]尤守唐,沈红艳.糖尿病肾病患者血清胆红素与血红蛋白的相关性及临床意义[J].中国医药指南,2015(13):16-17.
[7]杨丽萍,李平.糖尿病肾病合并贫血的相关发病机制研究进展[J].中国中西医结合肾病杂志,2009(10):172-174.
[8]Ritz E.Managing anemia and diabetes:a fut Lire challenge for nephrologist[J].Nephrol Dial Transplant,2005(Suppl6):21-25.