泄浊解毒方治疗高尿酸血症20例临床观察
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摘要
目的:观察泄浊解毒方治疗高尿酸血症的临床疗效。方法:将40例高尿酸血症患者随机分为治疗组和对照组,每组20例。治疗组给予泄浊解毒方口服治疗,对照组给予别嘌醇片治疗。2组均以4周为1个疗程。观察2组临床疗效,以及治疗前后血尿酸、肝肾功能、血脂等指标的变化。结果:治疗组显效2例,有效15例,无效3例,总有效率为85.00%;对照组显效1例,有效16例,无效3例,总有效率为85.00%。2组比较,差异无统计学意义(P>0.05)。治疗后,2组血尿酸较治疗前均明显降低(P<0.05),但2组间比较,差异无统计学意义(P>0.05);治疗组三酰甘油和胆固醇水平较治疗前明显降低(P<0.05);且肝肾功能受损较对照组轻。结论:泄浊解毒方对高尿酸血症治疗有较好作用,且无明显不良反应。
Objective:To observe the clinical efficacy of Xiezhuo Jiedu Fang(泄浊解毒方)in the treatment of hyperuricemia.Methods:Forty patients with hyperuricemia were randomly divided into a treatment group and a control group,with 20 cases in each.The treatment group was treated with Xiezhuo Jiedu Fang,while the control group was given allopurinol tablets.The two groups were treated with 4 weeks as a course.The clinical effects of two groups were observed,together with the changes of blood uric acid,liver and kidney function and blood lipid before and after treatment.Results:In the treatment group,2 cases were markedly effective,15 cases were effective,3 cases were invalid,and the total effective rate was 85.00%.In the control group,1 case was markedly effective,16 cases were effective,and 3 cases were ineffective,the total effective rate being 85.00%.The difference between the two groups was not statistically significant(P > 0.05).After treatment,the serum uric acid in both groups was significantly lower than that before treatment(P < 0.05),and there was no significant difference between the two groups(P > 0.05).Triglycerides and cholesterol levels in the treatment group were significantly lower than those before treatment(P < 0.05),and the damage to liver and kidney were smaller than that in the control group.Conclusion:Xiezhuo Jiedu Fang has a good effect on hyperuricemia,and there is no obvious adverse reaction.
Objective:To observe the clinical efficacy of Xiezhuo Jiedu Fang(泄浊解毒方)in the treatment of hyperuricemia.Methods:Forty patients with hyperuricemia were randomly divided into a treatment group and a control group,with 20 cases in each.The treatment group was treated with Xiezhuo Jiedu Fang,while the control group was given allopurinol tablets.The two groups were treated with 4 weeks as a course.The clinical effects of two groups were observed,together with the changes of blood uric acid,liver and kidney function and blood lipid before and after treatment.Results:In the treatment group,2 cases were markedly effective,15 cases were effective,3 cases were invalid,and the total effective rate was 85.00%.In the control group,1 case was markedly effective,16 cases were effective,and 3 cases were ineffective,the total effective rate being 85.00%.The difference between the two groups was not statistically significant(P > 0.05).After treatment,the serum uric acid in both groups was significantly lower than that before treatment(P < 0.05),and there was no significant difference between the two groups(P > 0.05).Triglycerides and cholesterol levels in the treatment group were significantly lower than those before treatment(P < 0.05),and the damage to liver and kidney were smaller than that in the control group.Conclusion:Xiezhuo Jiedu Fang has a good effect on hyperuricemia,and there is no obvious adverse reaction.
引文
[1]中国医师协会心血管内科医师分会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J].中国医学前沿杂志,2010,2(3):49-55.
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[7]施桂英.痛风——降尿酸治疗的新策略[J].中华风湿病学杂志,2007,11(3):129-131.
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[11]刘荣东,江慧梅,黄如萍.健脾化痰法对痰湿型代谢综合征中脂肪肝并高尿酸患者的影响[J].广州中医药大学学报,2012,29(3):239-242.
[12]王红霞,张相鹏.曹东义教授治疗急性痛风性关节炎经验[J].风湿病与关节炎,2017,6(6):47,75.
[13]郭淑云,张薇,张琰.土茯苓对高尿酸症小鼠血清尿酸的影响[J].中国药业,2012,21(13):3-4.
[14]赵岭梅.中药治疗高尿酸血症27例[J].中医杂志,2007,48(6):533-534.
[15]陈燕,陈肖霖,刘盂婷,等.基于高尿酸血症大鼠oatp1al表达的萆薢总皂苷降尿酸机制探讨[J].时珍国医国药,2015,26(10):2330-2332.
[16]姚丽,刘树民.穿山龙治疗急性痛风性关节炎有效部位的实验研究[J].中华中医药学刊,2010,28(8):1724-1726.
[17]侯建平,王亚军,严亚峰,等.虎杖提取物抗动物高尿酸血症的实验研究[J].西部中医药,2012,25(5):21-24.
[18]刘文波,李兴福.蛋白质组学技术在风湿性疾病中的应用[J].国外医学(内科学分册),2006,33(12):507-511.
[2]马力.高尿酸血症和代谢综合征[J].中国医刊,2010,15(8):18-19.
[3]KAO MP,ANG DS,GANDY SJ,et al.Allopurinol benefits left ventricular mass and endothelial dysfunction inchronic kidney disease[J].J Am Soc Nephrol,2011,22(7):1382-1389.
[4]KOSTKA-JEZIORNY K,URUSKI P,TYKARSKI A,et al.Effect of allo-purinol on blood pressure and aorticcompliance in hypertensive patients[J].BloodPress,2011,20(2):104-110.
[5]XU C,WAN X,XU L,et al.Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia:one stonehits two birds[J].J Hepatol,2015,62(6):1412-1419.
[6]秦晓东,孙立明.高尿酸血症与颈动脉病变的相关性[J].广东医学,2016,37(19):2914-2915.
[7]施桂英.痛风——降尿酸治疗的新策略[J].中华风湿病学杂志,2007,11(3):129-131.
[8]谢克琴,钟琴.中医药治疗高尿酸血症的作用机制研究进展[J].风湿病与关节炎,2016,5(10):77-80.
[9]中华医学会.临床诊疗指南·风湿病分册[M].北京:人民卫生出版社,2005:120.
[10]蔡浙毅,费秀丽,吴锋,等.中药尿酸方防治高尿酸血症疗效观察[J].辽宁中医杂志,2007,34(11):1579-1580.
[11]刘荣东,江慧梅,黄如萍.健脾化痰法对痰湿型代谢综合征中脂肪肝并高尿酸患者的影响[J].广州中医药大学学报,2012,29(3):239-242.
[12]王红霞,张相鹏.曹东义教授治疗急性痛风性关节炎经验[J].风湿病与关节炎,2017,6(6):47,75.
[13]郭淑云,张薇,张琰.土茯苓对高尿酸症小鼠血清尿酸的影响[J].中国药业,2012,21(13):3-4.
[14]赵岭梅.中药治疗高尿酸血症27例[J].中医杂志,2007,48(6):533-534.
[15]陈燕,陈肖霖,刘盂婷,等.基于高尿酸血症大鼠oatp1al表达的萆薢总皂苷降尿酸机制探讨[J].时珍国医国药,2015,26(10):2330-2332.
[16]姚丽,刘树民.穿山龙治疗急性痛风性关节炎有效部位的实验研究[J].中华中医药学刊,2010,28(8):1724-1726.
[17]侯建平,王亚军,严亚峰,等.虎杖提取物抗动物高尿酸血症的实验研究[J].西部中医药,2012,25(5):21-24.
[18]刘文波,李兴福.蛋白质组学技术在风湿性疾病中的应用[J].国外医学(内科学分册),2006,33(12):507-511.